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Nek1 Gene Detail
Summary
  • Symbol
    Nek1
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 1
  • Synonyms
    D8Ertd790e, kat, kidney, anemia and testis
  • Feature Type
    protein coding gene
  • IDs
    MGI:97303
    NCBI Gene: 18004
  • Gene Overview
    MyGene.info: NEK1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:60993195-61131346 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      138152 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 30.91 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    NEK1, NIMA related kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEK1, NIMA related kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS24, NY-REN-55, SRPS2, SRPS2A, SRTD6
  • Links
    NCBI Gene ID: 4750
    neXtProt AC: NX_Q96PY6
    UniProt: Q96PY6

  • Chr Location
    4q33; chr4:169393270-169612629 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 14376
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NEK1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Nek1 mouse models; 1 with human NEK1 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 2 alleles in 5 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Spontaneous mutations of this gene result in pleiotropic effects that include facial dysmorphism, dwarfism, male sterility, anemia, cystic choroid plexus, a late-onset slowly progressive polycystic kidney disease, and premature death. Postnatal survival is sensitive to genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031430 VEGA Gene Model | MGI Sequence Detail 138152 C57BL/6J ±  kb
    transcript OTTMUST00000148962 VEGA | MGI Sequence Detail 5109 Not Applicable  
    polypeptide OTTMUSP00000077359 VEGA | MGI Sequence Detail 1275 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      379 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • EC
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 29
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12816, MGD-MRK-38304, MGI:109259, MGI:1289217
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:2376 Letwin K, et al., A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J. 1992 Oct;11(10):3521-31
    • Latest
      J:246823 Brieno-Enriquez MA, et al., NIMA-related kinase 1 (NEK1) regulates meiosis I spindle assembly by altering the balance between alpha-Adducin and Myosin X. PLoS One. 2017;12(10):e0185780

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory