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Nek1
Gene Detail
 Symbol
Name
ID
Nek1
NIMA (never in mitosis gene a)-related expressed kinase 1
MGI:97303
Synonyms D8Ertd790e, kat, kidney, anemia and testis
Feature Type protein coding gene
Genetic Map
Chromosome 8
30.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr8:60993195-61131346 bp, + strand
From VEGA annotation of GRCm38

  138152 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14376  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nek1

Human
homologs
Human Homolog NEK1, NIMA-related kinase 1
NCBI Gene ID 4750
neXtProt AC  NX_Q96PY6
Human Synonyms  NY-REN-55, SRPS2, SRPS2A, SRTD6
Human Chr (Location)  4q33; chr4:169393270-169612629 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NEK1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Spontaneous(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Spontaneous mutations of this gene result in pleiotropic effects that include facial dysmorphism, dwarfism, male sterility, anemia, cystic choroid plexus, a late-onset slowly progressive polycystic kidney disease, and premature death. Postnatal survival is sensitive to genetic background.
 
Human Diseases Modeled Using Mouse Nek1 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Nek1 interacts with 282 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell cycle, cell division, ...
Component centrosome, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (48)    Tissues (14)    Images (19)
Theiler Stages: 20, 23, 28
Assay TypeResults
RNA in situ 37
Western blot 11
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(28) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000031430 (Evidence)
Ensembl Gene ModelENSMUSG00000031644 (Evidence)
Entrez Gene18004 (Evidence)
DFCITC1582305, TC1593842, TC1595987, TC1597589, TC1620215, TC1654684
DoTSDT.101735484, DT.55146382, DT.55210390, DT.87032680, DT.94130738, DT.94189081, DT.94287456, DT.97412204
NIA Mouse Gene IndexU009368
EC2.7.11.1
Consensus CDS ProjectCCDS40347.1
International Mouse Knockout Project StatusNek1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031430 VEGA Gene Model | MGI Sequence Detail 138152 C57BL/6J ±  kb
transcript OTTMUST00000077869 VEGA | MGI Sequence Detail 5478 Not Applicable 
polypeptide OTTMUSP00000041279 VEGA | MGI Sequence Detail 1231 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(14) UniProt(10)
Polymorphisms RFLP(1) : SNPs within 2kb(381 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000011125 serine/threonine-protein kinase Nek1
References (Earliest) J:2376 Letwin K, et al., A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J. 1992 Oct;11(10):3521-31
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(48)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12816, MGD-MRK-38304, MGI:109259, MGI:1289217

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory