Nek1
Gene Detail

Symbol Name ID

Nek1 NIMA (never in mitosis gene a)-related expressed kinase 1 MGI:97303

Synonyms

D8Ertd790e, kat, kidney, anemia and testis

Feature Type

protein coding gene

Genetic Map

Chromosome 8

30.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr8:60993195-61131346 bp, + strand From VEGA annotation of GRCm38   138152 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14376  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Nek1

Human homologs

Human Homolog		NEK1, NIMA-related kinase 1
NCBI Gene ID		4750
neXtProt AC		NX_Q96PY6
Human Synonyms		NY-REN-55, SRPS2, SRPS2A
Human Chr (Location)		4q33; chr4:170314421-170533778 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NEK1

Alleles and phenotypes

All alleles(4) : Targeted(1) Gene trapped(1) Spontaneous(2)
 

Spontaneous mutations of this gene result in pleiotropic effects that include facial dysmorphism, dwarfism, male sterility, anemia, cystic choroid plexus, a late-onset slowly progressive polycystic kidney disease, and premature death. Postnatal survival is sensitive to genetic background.

 
Human Diseases Modeled Using Mouse Nek1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	cell cycle, cell division, ...
Component	centrosome, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (48)    Tissues (14)    Images (19)
Theiler Stages: 20, 23, 28

Assay Type	Results
RNA in situ	37
Western blot	11

cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(78) cDNA(76) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031430 (Evidence)
Ensembl Gene Model	ENSMUSG00000031644 (Evidence)
Entrez Gene	18004 (Evidence)
UniGene	116649
DFCI	TC1582305, TC1593842, TC1595987, TC1597589, TC1620215, TC1654684
DoTS	DT.101735484, DT.55146382, DT.55210390, DT.87032680, DT.94130738, DT.94189081, DT.94287456, DT.97412204
NIA Mouse Gene Index	U009368
EC	2.7.11.1
Consensus CDS Project	CCDS40347.1
International Mouse Knockout Project Status	Nek1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031430	VEGA Gene Model | MGI Sequence Detail	138152	C57BL/6J
transcript	OTTMUST00000077869	VEGA | MGI Sequence Detail	5478	Not Applicable
polypeptide	OTTMUSP00000041279	VEGA | MGI Sequence Detail	1231	Not Applicable

All sequences(71) RefSeq(2) UniProt(10)

Polymorphisms

RFLP(1) : SNPs(338 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000011125	serine/threonine-protein kinase Nek1

References

(Earliest) J:2376 Letwin K, et al., A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J. 1992 Oct;11(10):3521-31
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(49)

Other accession IDs

MGD-MRK-12816, MGD-MRK-38304, MGI:109259, MGI:1289217