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Il6st Gene Detail
Summary
  • Symbol
    Il6st
  • Name
    interleukin 6 signal transducer
  • Synonyms
    5133400A03Rik, CD130, D13Ertd699e, gp130
  • Feature Type
    protein coding gene
  • IDs
    MGI:96560
    NCBI Gene: 16195
  • Gene Overview
    MyGene.info: IL6ST
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:112464070-112510086 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46017 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 63.73 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    IL6ST, interleukin 6 signal transducer
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL6ST, interleukin 6 signal transducer
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD130, CDW130, GP130, IL-6RB
  • Links
    NCBI Gene ID: 3572
    neXtProt AC: NX_P40189
    UniProt: P40189

  • Chr Location
    5q11.2; chr5:55935095-55994993 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1645
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: IL6ST
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Il6st mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    161 phenotypes from 10 alleles in 11 genetic backgrounds
    17 phenotypes from multigenic genotypes
    138 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations show myocardial and hematological defects and die between embryonic day 12.5 and term. Conditional mutants show female infertility and neurological, cardiac, hematopoietic, immunological, hepatic, and lung defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044624 VEGA Gene Model | MGI Sequence Detail 46017 C57BL/6J ±  kb
transcript OTTMUST00000117396 VEGA | MGI Sequence Detail 8678 Not Applicable  
polypeptide OTTMUSP00000065659 VEGA | MGI Sequence Detail 917 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    308 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 26
    cDNA 19
    Primer pair 4
    Other 3

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-11393, MGI:1277187, MGI:1918567, MGI:3034594, MGI:3034705
References
more
  • Summaries
    All 210
    Developmental Gene Expression 18
    Diseases 2
    Gene Ontology 15
    Phenotypes 138
  • Earliest
    J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
  • Latest
    J:239149 Alorro MG, et al., Generation of an inducible mouse model to reversibly silence Stat3. Genesis. 2017 Feb 07;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory