Il6st
Gene Detail

Symbol Name ID

Il6st interleukin 6 signal transducer MGI:96560

Synonyms

5133400A03Rik, CD130, D13Ertd699e, gp130

Feature Type

protein coding gene

Genetic Map

Chromosome 13

63.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr13:112475008-112506860 bp, + strand From Ensembl annotation of GRCm38   31853 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1645  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Il6st

Human homologs

Human Homolog		IL6ST, interleukin 6 signal transducer (gp130, oncostatin M receptor)
NCBI Gene ID		3572
neXtProt AC		NX_P40189
Human Synonyms		CD130, CDW130, GP130, IL-6RB
Human Chr (Location)		5q11.2; chr5:55230923-55290821 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(16) : Targeted(14) Gene trapped(2)
 

Homozygotes for targeted null mutations show myocardial and hematological defects and die between embryonic day 12.5 and term. Conditional mutants show female infertility and neurological, cardiac, hematopoietic, immunological, hepatic, and lung defects.

 
Human Diseases Modeled Using Mouse Il6st (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (50 annotations)

Process	ciliary neurotrophic factor-mediated signaling pathway, cytokine-mediated signaling pathway, ...
Component	cell body, ciliary neurotrophic factor receptor complex, ...
Function	ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (27)    Tissues (14)    Images (9)
Theiler Stages: 14, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	1
Western blot	4
RT-PCR	6
RNase protection	6

cDNA source data(141)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(145) cDNA(141) Primer pair(3) Other(1)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000021756 (Evidence)
Entrez Gene	16195 (Evidence)
UniGene	4364
DFCI	TC1574609, TC1665907
DoTS	DT.101363260, DT.101736461, DT.493560
NIA Mouse Gene Index	U015249
PDB	2HMH
Consensus CDS Project	CCDS26773.1
International Mouse Knockout Project Status	Il6st

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021756	Ensembl Gene Model | MGI Sequence Detail	31853	C57BL/6J
transcript	ENSMUST00000070731	Ensembl | MGI Sequence Detail	5207	Not Applicable
polypeptide	ENSMUSP00000064205	Ensembl | MGI Sequence Detail	917	Not Applicable

All sequences(40) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(245 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR010457	Immunoglobulin C2-set-like, ligand-binding
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR015321	Interleukin-6 receptor alpha chain, binding
InterPro	IPR003529	Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology	PR:000001868	interleukin-6 receptor subunit beta

References

(Earliest) J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
(Latest) J:193497 Kim G, et al., A Novel Role for IL-27 in Mediating the Survival of Activated Mouse CD4 T Lymphocytes. J Immunol. 2013 Feb 15;190(4):1510-8
All references(179)

Other accession IDs

MGD-MRK-11393, MGI:1277187, MGI:1918567, MGI:3034594, MGI:3034705