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Il6st
Gene Detail
Symbol

Name
ID
Il6st
interleukin 6 signal transducer
MGI:96560
Synonyms
5133400A03Rik, CD130, D13Ertd699e, gp130
Feature Type
protein coding gene
Genetic Map
Chromosome 13
63.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:112464070-112510086 bp, + strand
From VEGA annotation of GRCm38

  46017 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1645  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Il6st

Human
homologs
Human Homolog IL6ST, interleukin 6 signal transducer
NCBI Gene ID 3572
neXtProt AC  NX_P40189
Human Synonyms  CD130, CDW130, GP130, IL-6RB
Human Chr (Location)  5q11.2; chr5:55935095-55994993 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(10) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations show myocardial and hematological defects and die between embryonic day 12.5 and term. Conditional mutants show female infertility and neurological, cardiac, hematopoietic, immunological, hepatic, and lung defects.
 
Human Diseases Modeled Using Mouse Il6st (2)    Alleles Annotated to Human Diseases(2)   
Interactions
Il6st interacts with 321 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Expression
Literature Summary: (17 records)
Data Summary: Results (27)    Tissues (14)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 1
Western blot 4
RT-PCR 6
RNase protection 6
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(19) Primer pair(3) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000044624 (Evidence)
Ensembl Gene ModelENSMUSG00000021756 (Evidence)
Entrez Gene16195 (Evidence)
DFCITC1574609, TC1665907
DoTSDT.101363260, DT.101736461, DT.493560
NIA Mouse Gene IndexU015249
PDB2BBU, 2HMH, 4GL9
Consensus CDS ProjectCCDS26773.1
International Mouse Knockout Project StatusIl6st
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044624 VEGA Gene Model | MGI Sequence Detail 46017 C57BL/6J ±  kb
transcript OTTMUST00000117396 VEGA | MGI Sequence Detail 8678 Not Applicable 
polypeptide OTTMUSP00000065659 VEGA | MGI Sequence Detail 917 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(2) UniProt(10)
Polymorphisms
SNPs within 2kb(310 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR010457 Immunoglobulin C2-set-like, ligand-binding
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015321 Interleukin-6 receptor alpha chain, binding
InterPro IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology PR:000001868 interleukin-6 receptor subunit beta
References
(Earliest) J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
(Latest) J:212106 Nagayama Y, et al., Gp130-dependent signaling in the podocyte. Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F346-55
All references(191)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-11393, MGI:1277187, MGI:1918567, MGI:3034594, MGI:3034705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory