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Il6st
Gene Detail
Symbol

Name
ID
Il6st
interleukin 6 signal transducer
MGI:96560
Synonyms
5133400A03Rik, CD130, D13Ertd699e, gp130
Feature Type
protein coding gene
Genetic Map
Chromosome 13
63.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:112464070-112510086 bp, + strand
From VEGA annotation of GRCm38

  46017 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1645  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IL6ST
Gene Tree: Il6st

Human
homologs
IL6ST, interleukin 6 signal transducer
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3572
neXtProt AC: NX_P40189

Human Synonyms: CD130, CDW130, GP130, IL-6RB

Human Chr (Location): 5q11.2; chr5:55935095-55994993 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(10) Targeted(15)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations show myocardial and hematological defects and die between embryonic day 12.5 and term. Conditional mutants show female infertility and neurological, cardiac, hematopoietic, immunological, hepatic, and lung defects.
 
Human Diseases Modeled in Mice Using Il6st (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Il6st interacts with 320 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Expression
Literature Summary: (18 records)
Data Summary: Results (48)    Tissues (29)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 31
RNA in situ 1
Western blot 4
RT-PCR 6
RNase protection 6
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase il6st ; ZFIN il6st    NEW 
Molecular
reagents
All nucleic(23) cDNA(19) Primer pair(3) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000044624 (Evidence)
Ensembl Gene Model ENSMUSG00000021756 (Evidence)
Entrez Gene 16195 (Evidence)
DFCI TC1574609, TC1665907
DoTS DT.101363260, DT.101736461, DT.493560
NIA Mouse Gene Index U015249
PDB 2BBU, 2HMH, 4GL9
Consensus CDS Project CCDS26773.1
International Mouse Phenotyping Consortium Status Il6st
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044624 VEGA Gene Model | MGI Sequence Detail 46017 C57BL/6J ±  kb
transcript OTTMUST00000117396 VEGA | MGI Sequence Detail 8678 Not Applicable 
polypeptide OTTMUSP00000065659 VEGA | MGI Sequence Detail 917 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(2) UniProt(10)
Polymorphisms
SNPs within 2kb(310 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR010457 Immunoglobulin C2-set-like, ligand-binding
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015321 Interleukin-6 receptor alpha chain, binding
InterPro IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology PR:000001868 interleukin-6 receptor subunit beta
References
(Earliest) J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
(Latest) J:221281 Miller A, et al., Differential involvement of gp130 signalling pathways in modulating tobacco carcinogen-induced lung tumourigenesis. Oncogene. 2015 Mar 19;34(12):1510-9
All references(201)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-11393, MGI:1277187, MGI:1918567, MGI:3034594, MGI:3034705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory