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Il6st Gene Detail
Summary
  • Symbol
    Il6st
  • Name
    interleukin 6 signal transducer
  • Synonyms
    5133400A03Rik, CD130, D13Ertd699e, gp130
  • Feature Type
    protein coding gene
  • IDs
    MGI:96560
    NCBI Gene: 16195
  • Gene Overview
    MyGene.info: IL6ST
Location & Maps
more
  • Sequence Map
    Chr13:112464070-112510086 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46017 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 63.73 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    IL6ST, interleukin 6 signal transducer
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL6ST, interleukin 6 signal transducer
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD130, CDW130, GP130, IL-6RB
  • Links
    NCBI Gene ID: 3572
    neXtProt AC: NX_P40189

  • Chr Location
    5q11.2; chr5:55935095-55994993 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1645
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: IL6ST
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Il6st mouse models

Human Disease Mouse Models
       Gastric Cancer   OMIM: 613659 View 1 model
Rheumatoid Arthritis; RA   OMIM: 180300 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    160 phenotypes from 11 alleles in 12 genetic backgrounds
    12 phenotypes from multigenic genotypes
    132 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations show myocardial and hematological defects and die between embryonic day 12.5 and term. Conditional mutants show female infertility and neurological, cardiac, hematopoietic, immunological, hepatic, and lung defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044624 VEGA Gene Model | MGI Sequence Detail 46017 C57BL/6J ±  kb
transcript OTTMUST00000117396 VEGA | MGI Sequence Detail 8678 Not Applicable  
polypeptide OTTMUSP00000065659 VEGA | MGI Sequence Detail 917 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    308 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000001868 interleukin-6 receptor subunit beta
  • PDB
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR010457 Immunoglobulin C2-set-like, ligand-binding
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
    IPR015321 Type I cytokine receptor, cytokine-binding domain
Molecular
Reagents
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  • All nucleic 26
    cDNA 19
    Primer pair 4
    Other 3

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-11393, MGI:1277187, MGI:1918567, MGI:3034594, MGI:3034705
References
more
  • Summaries
    All 205
    Developmental Gene Expression 19
    Diseases 6
    Gene Ontology 15
    Phenotypes 132
  • Earliest
    J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
  • Latest
    J:231629 Thiem S, et al., Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model. Cancer Res. 2016 Apr 15;76(8):2277-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory