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Il6st Gene Detail
Summary
  • Symbol
    Il6st
  • Name
    interleukin 6 signal transducer
  • Synonyms
    5133400A03Rik, CD130, D13Ertd699e, gp130
  • Feature Type
    protein coding gene
  • IDs
    MGI:96560
    NCBI Gene: 16195
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:112600604-112643394 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 13, 63.73 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96560
protein coding gene Chr13:112600604-112646620 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020936
protein coding gene Chr13:115025884-115066341 (+)
A/J MGP_AJ_G0020886
protein coding gene Chr13:110430601-110477148 (+)
AKR/J MGP_AKRJ_G0020861
protein coding gene Chr13:113768957-113809884 (+)
BALB/cJ MGP_BALBcJ_G0020886
protein coding gene Chr13:111129220-111174772 (+)
C3H/HeJ MGP_C3HHeJ_G0020675
protein coding gene Chr13:113560453-113601541 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021322
protein coding gene Chr13:118447105-118488425 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018891
protein coding gene Chr13:105734420-105780095 (+)
CAST/EiJ MGP_CASTEiJ_G0020195
protein coding gene Chr13:113177176-113225763 (+)
CBA/J MGP_CBAJ_G0020637
protein coding gene Chr13:123020405-123062652 (+)
DBA/2J MGP_DBA2J_G0020760
protein coding gene Chr13:110148371-110189128 (+)
FVB/NJ MGP_FVBNJ_G0020744
protein coding gene Chr13:108840955-108886979 (+)
LP/J MGP_LPJ_G0020836
protein coding gene Chr13:115071191-115111341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020772
protein coding gene Chr13:123299808-123347564 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021358
protein coding gene Chr13:113211916-113257541 (+)
PWK/PhJ MGP_PWKPhJ_G0019948
protein coding gene Chr13:108884775-108930230 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019770
protein coding gene Chr13:109538148-109590868 (+)
WSB/EiJ MGP_WSBEiJ_G0020252
protein coding gene Chr13:113825151-113871082 (+)



Homology
more
  • Human Ortholog
    IL6ST, interleukin 6 cytokine family signal transducer
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL6ST, interleukin 6 cytokine family signal transducer
  • Synonyms
    CD130, CDW130, GP130, HIES4, HIES4A, HIES4B, IL-6RB, IMD94, sGP130, STWS2
  • Links
    NCBI Gene ID: 3572
    neXtProt AC: NX_P40189
    UniProt: P40189

  • Chr Location
    5q11.2; chr5:55935095-55995022 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with Il6st mouse models; 4 with human IL6ST associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    164 phenotypes from 10 alleles in 12 genetic backgrounds
    18 phenotypes from multigenic genotypes
    187 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations show myocardial and hematological defects and die between embryonic day 12.5 and term. Conditional mutants show female infertility and neurological, cardiac, hematopoietic, immunological, hepatic, and lung defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16195 NCBI Gene Model | MGI Sequence Detail 42791 C57BL/6J ±  kb
    transcript NM_010560 RefSeq | MGI Sequence Detail 5452 ZRU/MplStud  
    polypeptide Q00560 UniProt | EBI | MGI Sequence Detail 917 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 20
      Primer pair 6
      Other 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11393, MGI:1277187, MGI:1918567, MGI:3034594, MGI:3034705
    References
    more
    • Summaries
      All 290
      Developmental Gene Expression 26
      Diseases 2
      Gene Ontology 17
      Phenotypes 187
    • Earliest
      J:29552 Gearing DP, et al., Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839-48
    • Latest
      J:342593 Thilakasiri P, et al., Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3. Life Sci Alliance. 2024 Feb;7(2)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory