Phenotypes Associated with This Genotype

Genotype
MGI:3837032

• Allelic Composition: Il6st^tm1Ern/Il6st^tm1Ern
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal small intestine morphology ( J:79073 )

• age dependent enlargement of the proximal small intestine starting around 6-8 weeks of age

abnormal stomach morphology ( J:79073 )

abnormal stomach mucosa morphology ( J:79073 , J:87206 )

• hyperproliferative lesions in the antropyloric mucosa (J:79073)

• gastric outlet obstruction (J:79073)

• fewer mucus producing cells (J:79073)

• enlarged glandular structure with increased branching (J:79073)

• infiltrating lymphocytes abundant in the lamina propria and intraepithelial compartments (J:79073)

• non adenomatous stomach is hyperplastic with more pronounced rugae (J:87206)

• total area is increased from 16 weeks of age onward (J:87206)

enlarged stomach ( J:79073 )

• age dependent enlargement starting around 6-8 weeks of age

abnormal digestive system physiology ( J:87206 )

decreased susceptibility to induced colitis ( J:79073 )

• completely resistant to 3.5% dextran sodium sulfate

increased stomach pH ( J:87206 )

• in mice over 20 weeks of age

stomach inflammation ( J:87206 )

• gastritis is seen in all adults

• mixed mononuclear cells and polymorphonuclear leukocytes involved

immune system

enlarged spleen ( J:79073 )

• age dependent enlargement starting around 6-8 weeks of age

increased osteoclast cell number ( J:87612 )

abnormal inflammatory response ( J:139226 )

• neutrophil infiltration of the peritoneal cavity peaks more rapidly in induced inflammation than in controls (6 vs 12 hrs)

• neutrophils cleared more rapidly than in controls in induced inflammation

decreased susceptibility to induced colitis ( J:79073 )

• completely resistant to 3.5% dextran sodium sulfate

stomach inflammation ( J:87206 )

• gastritis is seen in all adults

• mixed mononuclear cells and polymorphonuclear leukocytes involved

increased susceptibility to induced arthritis ( J:142883 )

• increased overall severity of arthritis induced with methylated bovine serum albumin

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:79073 )

• completely resistant to 3.5% dextran sodium sulfate

neoplasm

increased adenoma incidence ( J:79073 , J:87206 )

• presence of pseudopolyploid diffuse adenomatous lesions in the stomach (J:79073)

• become larger and more numerous with age (J:87206)

• involve dysplastic cells and branching tortuous gastric glands (J:87206)

skeleton

increased osteoclast cell number ( J:87612 )

increased susceptibility to induced arthritis ( J:142883 )

• increased overall severity of arthritis induced with methylated bovine serum albumin

decreased compact bone thickness ( J:87612 )

increased osteoblast cell number ( J:87612 )

• on trabecular bone surfaces

abnormal trabecular bone morphology ( J:87612 )

• trabecular numbers reduced, particularly in males

decreased trabecular bone thickness ( J:87612 )

• trabecular thickness reduced, particularly in males

hematopoietic system

enlarged spleen ( J:79073 )

• age dependent enlargement starting around 6-8 weeks of age

increased osteoclast cell number ( J:87612 )

growth/size/body

enlarged spleen ( J:79073 )

• age dependent enlargement starting around 6-8 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
stomach cancer		DOID:10534	OMIM:613659	J:87206