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Symbol
Name
ID

Il6st
interleukin 6 signal transducer
MGI:96560

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Craniosynostosis	Scaphocephaly	Clubbing	Hip dislocation	Joint contracture of the hand	Scoliosis	Thoracolumbar scoliosis	Arthropathy
Disease(s) Associated with IL6ST
hyper IgE recurrent infection syndrome 4

Mouse Phenotypes

skeleton phenotype

abnormal osteoclast differentiation

abnormal osteoblast physiology

increased osteoclast cell number

abnormal osteoclast morphology

abnormal osteoclast physiology

joint swelling

increased susceptibility to induced arthritis

rheumatoid arthritis

bowed humerus

bowed radius

bowed ulna

abnormal femur morphology

bowed femur

decreased diameter of femur

short femur

bowed fibula

bowed tibia

abnormal skeleton morphology

abnormal long bone morphology

abnormal long bone diaphysis morphology

abnormal bone structure

increased bone mineral content

increased bone mineral density

decreased compact bone thickness

decreased osteoblast cell number

increased osteoblast cell number

abnormal trabecular bone morphology

decreased trabecular bone thickness

increased trabecular bone thickness

osteoporosis

abnormal joint morphology

abnormal synovial joint capsule morphology

increased bone mineralization

increased bone ossification

decreased joint mobility

Availability

Mouse Genotype

Il6st^tm1Ard/Il6st^tm1Ard

*

Il6st^tm1Ern/Il6st^tm1Ern

Il6st^tm1Kish/Il6st^tm1Kish

Il6st^tm1Thir/Il6st^tm1Thir

Il6st^tm2Thir/Il6st^tm2Thir

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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