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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il6st
interleukin 6 signal transducer
MGI:96560
18 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gkn2tm1.1(KOMP)Vlcg/Gkn2tm1.1(KOMP)Vlcg
Il6sttm1Ern/Il6sttm1Ern
involves: 129S1/Sv * C57BL/6NTac 		abnormal stomach mucosa morphology J:234656
increased stomach mucosa thickness J:234656
increased stomach tumor incidence J:234656
Ifnar2tm1Pjh/Ifnar2tm1Pjh
Il6sttm1Ern/Il6sttm1Ern
involves: 129S1/Sv 		increased circulating interleukin-6 level J:168781
increased susceptibility to endotoxin shock J:168781
increased susceptibility to xenobiotic induced morbidity/mortality J:168781
Il6tm1Kopf/Il6tm1Kopf
Il6sttm1Ern/Il6sttm1Ern
involves: 129S1/Sv * 129S2/SvPas 		decreased susceptibility to endotoxin shock J:168781
normal immune system phenotype J:139226
Il6sttm1Ern/Il6st+
Smad3tm1Par/Smad3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		increased adenoma incidence J:100160
Il6sttm1Ern/Il6sttm1Ern
Stat1tm1Rds/Stat1tm1Rds
involves: 129S1/Sv 		abnormal inflammatory response J:139226
Il6sttm1Ern/Il6sttm1Ern
Stat3tm1Aki/Stat3+
involves: 129P2/OlaHsd * 129S1/Sv 		decreased circulating interleukin-6 level J:168781
decreased susceptibility to endotoxin shock J:168781
normal digestive/alimentary phenotype J:100160
normal immune system phenotype J:100160, J:139226, J:142883
normal mortality/aging J:100160
normal neoplasm J:100160
Il6sttm1Ern/Il6sttm1Ern
Tg(RP11-H2112)5Trme/0
involves: 129S1/Sv * C57BL/6J * DBA/2J 		abnormal spleen size J:234656
abnormal stomach mucosa morphology J:234656
decreased stomach tumor incidence J:234656
Il6sttm1Ern/Il6sttm1Ern
Tg(RP11-H2112)9Trme/0
involves: 129S1/Sv * C57BL/6J * DBA/2J 		abnormal spleen size J:234656
abnormal stomach mucosa morphology J:234656
decreased stomach tumor incidence J:234656
Il6sttm1Ern/Il6sttm1Ern
Tiraptm1.1Pjh/Tiraptm1.1Pjh
involves: 129S1/Sv 		decreased circulating interleukin-6 level J:168781
decreased susceptibility to endotoxin shock J:168781
Il6sttm1Thir/Il6sttm1Thir
Rag2tm1Fwa/Rag2tm1Fwa
involves: 129S/SvEv * C57BL/6 		normal immune system phenotype J:133059
Il6sttm1Thir/Il6sttm1Thir
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129 * C57BL/6 * DBA 		abnormal negative T cell selection J:133059
Il6sttm4Thir/Il6sttm4Thir
Not Specified 		no abnormal phenotype detected J:59922
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory