Il6sttm4Thir
Targeted Allele Detail
|
Symbol: |
Il6sttm4Thir |
Name: |
interleukin 6 signal transducer; targeted mutation 4, Toshio Hirano |
MGI ID: |
MGI:3843614 |
Synonyms: |
gp130H |
Gene: |
Il6st Location: Chr13:112600604-112643394 bp, + strand Genetic Position: Chr13, 63.73 cM
|
Alliance: |
Il6sttm4Thir page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:59922
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
Not Specified
|
|
Allele Type: |
|
Targeted (Humanized sequence, Inserted expressed sequence) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: cDNA encoding the transmembrane and cytoplasmic domains of human IL6ST replaced the corresponding sequence of the mouse locus, yielding a mouse-human chimeric protein. The expression levels of the chimeric protein in homozygote B and T cells was similar to expression levels of endogenous protein in wild-type controls.
(J:59922)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Il6st Mutation: |
80 strains or lines available
|
|
Original: |
J:59922 Ohtani T, et al., Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity. 2000 Jan;12(1):95-105 |
All: |
1 reference(s) |
|