Il6st^tm4Thir
Targeted Allele Detail

Summary

• Symbol: Il6st^tm4Thir
• Name: interleukin 6 signal transducer; targeted mutation 4, Toshio Hirano
• MGI ID: MGI:3843614
• Synonyms: gp130^H
• Gene: Il6st Location: Chr13:112600604-112643394 bp, + strand Genetic Position: Chr13, 63.73 cM
• Alliance: Il6st^tm4Thir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59922
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: cDNA encoding the transmembrane and cytoplasmic domains of human IL6ST replaced the corresponding sequence of the mouse locus, yielding a mouse-human chimeric protein. The expression levels of the chimeric protein in homozygote B and T cells was similar to expression levels of endogenous protein in wild-type controls. (J:59922)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6st Mutation: 85 strains or lines available

References

• Original: J:59922 Ohtani T, et al., Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity. 2000 Jan;12(1):95-105
• All: 1 reference(s)