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Targeted Allele Detail
Symbol: Il6sttm1Thir
Name: interleukin 6 signal transducer; targeted mutation 1, Toshio Hirano
MGI ID: MGI:2386991
Synonyms: F759, gp130F759
Gene: Il6st  Location: Chr13:112600604-112643394 bp, + strand  Genetic Position: Chr13, 63.73 cM
Alliance: Il6sttm1Thir page
Germline Transmission:  Earliest citation of germline transmission: J:59922
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Humanized sequence)
Mutation:    Nucleotide substitutions
Mutation detailsA human Il6st cDNA fragment carrying a tyrosine to phenylalanine substitution at position 759 (Y759F), was used to replaced the corresponding region of the mouse gene. A downstream neomycin resistance cassette was also inserted for positive selection. The expression level of the mutant protein in B- and T-cells is similar to that of wild-type as determined by flow cytometry. (J:59922)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il6st Mutation:  64 strains or lines available
Original:  J:59922 Ohtani T, et al., Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity. 2000 Jan;12(1):95-105
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory