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Il4 Gene Detail
Summary
  • Symbol
    Il4
  • Name
    interleukin 4
  • Synonyms
    Il-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96556
    NCBI Gene: 16189
  • Gene Overview
    MyGene.info: IL4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:53612460-53618665 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.97 cM
  • Mapping Data
    43 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96556
protein coding gene Chr11:53602982-53618669 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018300
protein coding gene Chr11:52998742-53014350 (-)
A/J MGP_AJ_G0018269
protein coding gene Chr11:51006405-51022033 (-)
AKR/J MGP_AKRJ_G0018239
protein coding gene Chr11:52677109-52694704 (-)
BALB/cJ MGP_BALBcJ_G0018240
protein coding gene Chr11:51363906-51379480 (-)
C3H/HeJ MGP_C3HHeJ_G0018051
protein coding gene Chr11:52641062-52658717 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018692
protein coding gene Chr11:54596617-54616468 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016342
protein coding gene Chr11:48544087-48559578 (-)
CAST/EiJ MGP_CASTEiJ_G0017616
protein coding gene Chr11:52688747-52704226 (-)
CBA/J MGP_CBAJ_G0018026
protein coding gene Chr11:57181603-57202811 (-)
DBA/2J MGP_DBA2J_G0018136
protein coding gene Chr11:50753481-50771775 (-)
FVB/NJ MGP_FVBNJ_G0018128
protein coding gene Chr11:50396420-50413813 (-)
LP/J MGP_LPJ_G0018210
protein coding gene Chr11:53443783-53465319 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018152
protein coding gene Chr11:58490925-58509216 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018734
protein coding gene Chr11:52706245-52723243 (-)
PWK/PhJ MGP_PWKPhJ_G0017391
protein coding gene Chr11:51270330-51286076 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017186
protein coding gene Chr11:52511241-52527247 (-)
WSB/EiJ MGP_WSBEiJ_G0017663
protein coding gene Chr11:52338803-52354895 (-)



Homology
more
  • Human Ortholog
    IL4, interleukin 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL4, interleukin 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BCGF1, BCGF-1, BSF1, BSF-1, IL-4
  • Links
    NCBI Gene ID: 3565
    neXtProt AC: NX_P05112
    UniProt: P05112

  • Chr Location
    5q31.1; chr5:132673986-132682678 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Il4 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 2 models
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    107 phenotypes from 16 alleles in 29 genetic backgrounds
    73 phenotypes from multigenic genotypes
    565 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out alleles exhibit defects in immune system morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16189 NCBI Gene Model | MGI Sequence Detail 6206 C57BL/6J ±  kb
    transcript NR_027491 RefSeq | MGI Sequence Detail 624 C57BL/6  
    polypeptide P07750 UniProt | EBI | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 11
      cDNA 15
      Primer pair 7
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11355, MGD-MRK-11385
    References
    more
    • Summaries
      All 1067
      Developmental Gene Expression 16
      Diseases 3
      Gene Ontology 54
      Phenotypes 565
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265033 Zhu L, et al., TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018 Jul 18;9(1):2812

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory