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Il4
Gene Detail
Symbol

Name
ID
Il4
interleukin 4
MGI:96556
Synonyms
Il-4
Feature Type
protein coding gene
Genetic Map
Chromosome 11
31.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(43)
Sequence Map
Chr11:53602982-53618669 bp, - strand
From VEGA annotation of GRCm38

  15688 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:491  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL4
Protein SuperFamily: interleukin-4
Gene Tree: Il4

Human
homologs
IL4, interleukin 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3565
neXtProt AC: NX_P05112

Human Synonyms: BCGF1, BCGF-1, BSF1, BSF-1, IL-4

Human Chr (Location): 5q31.1; chr5:132673986-132682678 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Targeted(16) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for knock-out alleles exhibit defects in immune system morphology and physiology.
 
Human Diseases Modeled in Mice Using Il4 (3)    Mutations Annotated to Human Diseases (2)   
Interactions
Il4 interacts with 17 markers (Mir98, Mir183, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process B cell activation, B cell costimulation, ...
Component external side of plasma membrane, extracellular region, ...
Function cytokine activity, cytokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (50)    Tissues (27)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 44
Nuclease S1 6
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(11) cDNA(14) Primer pair(6) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000005642 (Evidence)
Ensembl Gene Model ENSMUSG00000000869 (Evidence)
Entrez Gene 16189 (Evidence)
UniGene 276360
DFCI TC1588033, TC1652072
DoTS DT.530186, DT.94153869
NIA Mouse Gene Index U032765
Consensus CDS Project CCDS24682.1
International Mouse Phenotyping Consortium Status Il4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005642 VEGA Gene Model | MGI Sequence Detail 15688 C57BL/6J ±  kb
transcript OTTMUST00000012550 VEGA | MGI Sequence Detail 590 Not Applicable 
polypeptide OTTMUSP00000005817 VEGA | MGI Sequence Detail 140 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(3) UniProt(4)
Polymorphisms
All PCR and RFLP(9) : PCR(4) RFLP(5) SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR002354 Interleukin-4
InterPro IPR001325 Interleukin-4/interleukin-13
InterPro IPR018096 Interleukin-4/interleukin-13, conserved site
Protein Ontology PR:000001391 interleukin-4
References
(Earliest) J:39743 Howard M, et al., Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J Exp Med. 1982 Mar 1;155(3):914-23
(Latest) J:220386 Walsh JT, et al., MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. J Clin Invest. 2015 Feb;125(2):699-714
All references(843)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-11355, MGD-MRK-11385

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory