Il4
Gene Detail

Symbol Name ID

Il4 interleukin 4 MGI:96556

Synonyms

Il-4

Feature Type

protein coding gene

Genetic Map

Chromosome 11

31.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(43)

Sequence Map

Chr11:53602982-53618669 bp, - strand From VEGA annotation of GRCm38   15688 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:491  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: interleukin-4
Gene Tree: Il4

Human homologs

Human Homolog		IL4, interleukin 4
NCBI Gene ID		3565
neXtProt AC		NX_P05112
Human Synonyms		BCGF1, BCGF-1, BSF1, BSF-1, IL-4
Human Chr (Location)		5q31.1; chr5:132009678-132018370 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(16) : Targeted(16)
 

Mice homozygous for knock-out alleles exhibit defects in immune system morphology and physiology.

 
Human Diseases Modeled Using Mouse Il4 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (53 annotations)

Process	B cell activation, B cell costimulation, ...
Component	external side of plasma membrane, extracellular region, ...
Function	cytokine activity, cytokine receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (50)    Tissues (26)    Images (2)
Theiler Stages: 13, 17, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RT-PCR	44
Nuclease S1	6

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(11) cDNA(14) Primer pair(6) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000005642 (Evidence)
Ensembl Gene Model	ENSMUSG00000000869 (Evidence)
Entrez Gene	16189 (Evidence)
UniGene	276360
DFCI	TC1588033, TC1652072
DoTS	DT.530186, DT.94153869
NIA Mouse Gene Index	U032765
Consensus CDS Project	CCDS24682.1
International Mouse Knockout Project Status	Il4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005642	VEGA Gene Model | MGI Sequence Detail	15688	C57BL/6J
transcript	OTTMUST00000012550	VEGA | MGI Sequence Detail	590	Not Applicable
polypeptide	OTTMUSP00000005817	VEGA | MGI Sequence Detail	140	Not Applicable

All sequences(43) RefSeq(3) UniProt(4)

Polymorphisms

All PCR and RFLP(9) : PCR(4) RFLP(5) SNPs(64 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR002354	Interleukin-4
InterPro	IPR001325	Interleukin-4/interleukin-13
InterPro	IPR018096	Interleukin-4/interleukin-13, conserved site
Protein Ontology	PR:000001391	interleukin-4

References

(Earliest) J:39743 Howard M, et al., Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J Exp Med. 1982 Mar 1;155(3):914-23
(Latest) J:195232 Abston ED, et al., TLR3 deficiency induces chronic inflammatory cardiomyopathy in resistant mice following coxsackievirus B3 infection: role for IL-4. Am J Physiol Regul Integr Comp Physiol. 2013 Feb 15;304(4):R267-77
All references(807)

Other accession IDs

MGD-MRK-11355, MGD-MRK-11385