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Rr250409 Other Genome Feature Detail
Summary
  • Symbol
    Rr250409
  • Name
    regulatory region 250409
  • Synonyms
    Cigs1, CNS-1, HSS1, HSS2
  • Feature Type
    enhancer
  • IDs
    MGI:7138631
Location &
Maps
more
  • Sequence Map
    Chr11:53517402-53519171 bp, . strand
    From Ensembl Reg annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • J:66158 Fig2a: left GAGGCCTCATTATCTTCATTCATTTCTCGGCTCCACCCAAAA chr11:53517951-53517992 (GRCm39) right GCATTGCTCTTCCTGCAGCCCTTGTGCGGCAGCAGCCCTCA chr11:53517587-53517627
  • Genetic Map
    Chromosome 11, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
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  • SNPs within 2kb
    42 from dbSNP Build 142
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced interleukin production and IgE serum levels when stimulated under TH2 conditions.
Sequences &
Gene Models
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  • All Sequences
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSR00000042608 Ensembl | MGI Sequence Detail 1770 Not Applicable ±  kb
For the selected sequence
Other Database
Links
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Ensembl Regulatory Feature ENSMUSR00000042608
References
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  • Summaries
    All 7
    Phenotypes 3
  • Earliest
    J:61463 Loots GG, et al., Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons [see comments]. Science. 2000 Apr 7;288(5463):136-40
  • Latest
    J:167446 Tanaka S, et al., The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat Immunol. 2011 Jan;12(1):77-85
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory