Phenotypes Associated with This Genotype

Genotype
MGI:3625060

• Allelic Composition: Il4^tm1Cgn/Il4^tm1Cgn
• Genetic Background: either: NOD.129-Il4^tm1Cgn or (involves: 129 * NOD)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

insulitis ( J:85924 )

• at 12 weeks, insulitis incidence is similar in homozygous mutants and heterozygous controls on the NOD background (N4)

immune system

insulitis ( J:85924 )

• at 12 weeks, insulitis incidence is similar in homozygous mutants and heterozygous controls on the NOD background (N4)

autoimmune response ( J:85924 )

• there is no difference in timing or penetrance of diabetes in IL4-deficient NOD mice (N8) compared to heterozygous or wild-type NOD mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:85924