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Irf8 Gene Detail
Summary
  • Symbol
    Irf8
  • Name
    interferon regulatory factor 8
  • Synonyms
    ICSBP, Icsbp1, IRF-8, Myls
  • Feature Type
    protein coding gene
  • IDs
    MGI:96395
    NCBI Gene: 15900
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:121463097-121483433 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 70.05 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96395
protein coding gene Chr8:121463097-121483433 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034206
protein coding gene Chr8:124187579-124209006 (+)
A/J MGP_AJ_G0034186
protein coding gene Chr8:119026234-119046564 (+)
AKR/J MGP_AKRJ_G0034113
protein coding gene Chr8:122496932-122517268 (+)
BALB/cJ MGP_BALBcJ_G0034180
protein coding gene Chr8:119242237-119263173 (+)
C3H/HeJ MGP_C3HHeJ_G0033891
protein coding gene Chr8:123228482-123248652 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034700
protein coding gene Chr8:128318723-128340680 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031642
protein coding gene Chr8:111894739-111914837 (+)
CAST/EiJ MGP_CASTEiJ_G0033218
protein coding gene Chr8:123223585-123243898 (+)
CBA/J MGP_CBAJ_G0033864
protein coding gene Chr8:133009714-133032226 (+)
DBA/2J MGP_DBA2J_G0034020
protein coding gene Chr8:118241777-118262004 (+)
FVB/NJ MGP_FVBNJ_G0033963
protein coding gene Chr8:117318585-117339278 (+)
LP/J MGP_LPJ_G0034109
protein coding gene Chr8:124308760-124330546 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034010
protein coding gene Chr8:135361623-135382973 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034718
protein coding gene Chr8:122668459-122690095 (+)
PWK/PhJ MGP_PWKPhJ_G0032920
protein coding gene Chr8:118026211-118046775 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032760
protein coding gene Chr8:121372637-121398386 (+)
WSB/EiJ MGP_WSBEiJ_G0033334
protein coding gene Chr8:123405259-123427167 (+)



Homology
more
  • Human Ortholog
    IRF8, interferon regulatory factor 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRF8, interferon regulatory factor 8
  • Synonyms
    H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8
  • Links
    NCBI Gene ID: 3394
    neXtProt AC: NX_Q02556
    UniProt: Q02556

  • Chr Location
    16q24.1; chr16:85899168-85922606 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Irf8 mouse models; 2 with human IRF8 associations

Human Disease Mouse Models
      
IDs
View 4 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 7 alleles in 9 genetic backgrounds
    18 phenotypes from multigenic genotypes
    175 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit increased incidence of viral infections, shortened life span, deregulated hematopoiesis, and hematological neoplasias. Heterozygotes show similar, but milder, phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15900 NCBI Gene Model | MGI Sequence Detail 20337 C57BL/6J ±  kb
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 3
      cDNA 95
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11151, MGI:2142648, MGI:3574547
    References
    more
    • Summaries
      All 260
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 13
      Phenotypes 175
    • Earliest
      J:17559 Driggers PH, et al., An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci U S A. 1990 May;87(10):3743-7
    • Latest
      J:322321 Catela C, et al., Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity. Elife. 2022 Mar 22;11:e70766

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/10/2022
    MGI 6.19
    The Jackson Laboratory