Irf8
Gene Detail

Symbol Name ID

Irf8 interferon regulatory factor 8 MGI:96395

Synonyms

ICSBP, Icsbp1, IRF-8, Myls

Feature Type

protein coding gene

Genetic Map

Chromosome 8

70.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr8:120736358-120756694 bp, + strand From VEGA annotation of GRCm38   20337 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1629  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf8

Human homologs

Human Homolog		IRF8, interferon regulatory factor 8
NCBI Gene ID		3394
neXtProt AC		NX_Q02556
Human Synonyms		H-ICSBP, ICSBP, ICSBP1, IRF-8
Human Chr (Location)		16q24.1; chr16:85932774-85956212 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(5) Spontaneous(1) Chemically induced(1)
 

Homozygotes for a targeted null mutation exhibit increased incidence of viral infections, shortened life span, deregulated hematopoiesis, and hematological neoplasias. Heterozygotes show similar, but milder, phenotypes.

 
Human Diseases Modeled Using Mouse Irf8 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cellular response to lipopolysaccharide, defense response to bacterium, ...
Component	nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (199)    Tissues (157)    Images (18)
Theiler Stages: 2, 3, 4, 5, 16, 17, 21, 22, 23, 28

Assay Type	Results
RNA in situ	180
Western blot	2
RT-PCR	17

cDNA source data(90)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(96) Genomic(3) cDNA(90) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000033858 (Evidence)
Ensembl Gene Model	ENSMUSG00000041515 (Evidence)
Entrez Gene	15900 (Evidence)
UniGene	334861
DFCI	TC1572080, TC1677434
DoTS	DT.110893431, DT.534022
NIA Mouse Gene Index	U009890
Consensus CDS Project	CCDS22721.1
International Mouse Knockout Project Status	Irf8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033858	VEGA Gene Model | MGI Sequence Detail	20337	C57BL/6J
transcript	OTTMUST00000085323	VEGA | MGI Sequence Detail	2270	Not Applicable
polypeptide	OTTMUSP00000046088	VEGA | MGI Sequence Detail	424	Not Applicable

All sequences(68) RefSeq(2) UniProt(10)

Polymorphisms

RFLP(2) : SNPs(73 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019471	Interferon regulatory factor-3
InterPro	IPR019817	Interferon regulatory factor, conserved site
InterPro	IPR001346	Interferon regulatory factor DNA-binding domain
InterPro	IPR017855	SMAD domain-like
InterPro	IPR008984	SMAD/FHA domain
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000002050	interferon regulatory factor 8

References

(Earliest) J:17559 Driggers PH, et al., An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci U S A. 1990 May;87(10):3743-7
(Latest) J:195891 Kurotaki D, et al., Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. Blood. 2013 Mar 7;121(10):1839-49
All references(139)

Other accession IDs

MGD-MRK-11151, MGI:2142648, MGI:3574547