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Irf8
Gene Detail
Symbol

Name
ID
Irf8
interferon regulatory factor 8
MGI:96395
Synonyms
ICSBP, Icsbp1, IRF-8, Myls
Feature Type
protein coding gene
Genetic Map
Chromosome 8
70.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr8:120736358-120756694 bp, + strand
From VEGA annotation of GRCm38

  20337 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1629  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IRF8
Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf8

Human
homologs
IRF8, interferon regulatory factor 8
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3394
neXtProt AC: NX_Q02556

Human Synonyms: H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8

Human Chr (Location): 16q24.1; chr16:85899168-85922606 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human IRF8

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit increased incidence of viral infections, shortened life span, deregulated hematopoiesis, and hematological neoplasias. Heterozygotes show similar, but milder, phenotypes.
 
Human Diseases Modeled in Mice Using Irf8 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Irf8 interacts with 142 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cellular response to lipopolysaccharide, defense response to bacterium, ...
Component nucleoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (192)    Tissues (153)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 180
Western blot 2
RT-PCR 10
cDNA source data(94)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase irf8 ; ZFIN irf8    NEW 
Molecular
reagents
All nucleic(100) Genomic(3) cDNA(94) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033858 (Evidence)
Ensembl Gene Model ENSMUSG00000041515 (Evidence)
Entrez Gene 15900 (Evidence)
UniGene 334861
DFCI TC1572080, TC1677434
DoTS DT.110893431, DT.534022
NIA Mouse Gene Index U009890
Consensus CDS Project CCDS22721.1
International Mouse Phenotyping Consortium Status Irf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033858 VEGA Gene Model | MGI Sequence Detail 20337 C57BL/6J ±  kb
transcript OTTMUST00000085321 VEGA | MGI Sequence Detail 2847 Not Applicable 
polypeptide OTTMUSP00000046087 VEGA | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(4) UniProt(10)
Polymorphisms
RFLP(2) : SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002050 interferon regulatory factor 8
References
(Earliest) J:17559 Driggers PH, et al., An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci U S A. 1990 May;87(10):3743-7
(Latest) J:220775 Sasaki H, et al., Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells. Blood. 2015 Jan 8;125(2):358-69
All references(161)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11151, MGI:2142648, MGI:3574547

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory