H2-Aa
Gene Detail

Symbol Name ID

H2-Aa histocompatibility 2, class II antigen A, alpha MGI:95895

Synonyms

Aalpha, A alpha, H-2Aa, Ia1, Ia-1, I-Aalpha

Feature Type

protein coding gene

Genetic Map

Chromosome 17

17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr17:34282744-34287827 bp, - strand From VEGA annotation of GRCm38   5084 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:123820  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: H2-Aa

Human homologs

Human Homolog		HLA-DQA1, major histocompatibility complex, class II, DQ alpha 1
NCBI Gene ID		3117
neXtProt AC		NX_P01909
Human Synonyms		CD, CELIAC1, DQ-A1, GSE, HLA-DQA
Human Chr (Location)		6p21.3; chr6:32605183-32611429 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HLA-DQA1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele lack cell surface expression of MHC class II molecules on macrophages and show decreased CD4-positive T cell number, increased CD8-positive T cell number, thymus hyperplasia, enlarged lymph nodes, and altered splenocyte response to staphylococcal enterotoxin B.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	peptide antigen binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (48)    Tissues (30)    Images (19)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	48

cDNA source data(271)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(293) Genomic(16) cDNA(272) Primer pair(3) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000037121 (Evidence)
Ensembl Gene Model	ENSMUSG00000036594 (Evidence)
Entrez Gene	14960 (Evidence)
UniGene	235338
DFCI	TC1571966, TC1588238, TC1728757, TC1761443
DoTS	DT.110551673, DT.495080, DT.91290396, DT.91344507, DT.94412154
NIA Mouse Gene Index	U037709
PDB	1D9K, 1F3J, 1IAK, 1IAO, 1K2D, 1LNU, 1MUJ, 1U3H, 2IAD, 2PXY, 3C5Z, 3C6L, 3CUP, 3MBE, 3RDT, 1ES0, 1JL4, 2P24, 2Z31, 3C60
Consensus CDS Project	CCDS28645.1
International Mouse Knockout Project Status	H2-Aa

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037121	VEGA Gene Model | MGI Sequence Detail	5084	C57BL/6J
transcript	OTTMUST00000095576	VEGA | MGI Sequence Detail	1132	Not Applicable
polypeptide	OTTMUSP00000053329	VEGA | MGI Sequence Detail	256	Not Applicable

All sequences(70) RefSeq(2) UniProt(17)

Polymorphisms

All PCR and RFLP(14) : PCR(2) RFLP(12) SNPs(140 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003597	Immunoglobulin C1-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
InterPro	IPR011162	MHC classes I/II-like antigen recognition protein
InterPro	IPR014745	MHC class II, alpha/beta chain, N-terminal
InterPro	IPR001003	MHC class II, alpha chain, N-terminal
Protein Ontology	PR:000002013	MHC class II histocompatibility antigen alpha chain HLA-DQA1

References

(Earliest) J:5527 Shreffler DC, et al., The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization. Adv Immunol. 1975;20:125-95
(Latest) J:184531 Zelenay S, et al., The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice. J Clin Invest. 2012 May 1;122(5):1615-27
All references(107)

Other accession IDs

MGD-MRK-10377, MGD-MRK-10490, MGD-MRK-11044, MGD-MRK-11049