Gata4
Gene Detail

Symbol Name ID

Gata4 GATA binding protein 4 MGI:95664

Synonyms

Gata-4

Feature Type

protein coding gene

Genetic Map

Chromosome 14

33.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr14:63198922-63271692 bp, - strand From VEGA annotation of GRCm38   72771 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor GATA-4/5/6 types
Gene Tree: Gata4

Human homologs

Human Homolog		GATA4, GATA binding protein 4
NCBI Gene ID		2626
neXtProt AC		NX_P43694
Human Synonyms		ASD2, VSD1
Human Chr (Location)		8p23.1-p22; chr8:11561717-11617509 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human GATA4

Alleles and phenotypes

All alleles(18) : Targeted(15) Gene trapped(2) Transgenic(1)
 

Homozygotes for targeted null mutations exhibit defects in ventral morphogenesis, lack a primitive heart tube and foregut, develop partially outside the yolk sac, and die by midgestation.

 
Human Diseases Modeled Using Mouse Gata4 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (121 annotations)

Process	atrial septum morphogenesis, atrial septum primum morphogenesis, ...
Component	nucleus
Function	activating transcription factor binding, chromatin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (270 records)
Data Summary: Results (434)    Tissues (186)    Images (118)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	47
RNA in situ	238
Northern blot	22
RT-PCR	127

cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(60) Genomic(4) cDNA(39) Primer pair(11) Other(6)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000032593 (Evidence)
Ensembl Gene Model	ENSMUSG00000021944 (Evidence)
Entrez Gene	14463 (Evidence)
UniGene	247669
DFCI	TC1582407
DoTS	DT.110768372, DT.530169
NIA Mouse Gene Index	U035668
Consensus CDS Project	CCDS49519.1
International Mouse Knockout Project Status	Gata4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032593	VEGA Gene Model | MGI Sequence Detail	72771	C57BL/6J
transcript	OTTMUST00000081055	VEGA | MGI Sequence Detail	3400	Not Applicable
polypeptide	OTTMUSP00000043285	VEGA | MGI Sequence Detail	442	Not Applicable

All sequences(54) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(2) : SNPs(148 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008013	GATA-type transcription activator, N-terminal
InterPro	IPR016375	Transcription factor GATA-4/5/6
InterPro	IPR000679	Zinc finger, GATA-type
InterPro	IPR013088	Zinc finger, NHR/GATA-type
Protein Ontology	PR:000007859	transcription factor GATA-4

References

(Earliest) J:4641 Arceci RJ, et al., Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993 Apr;13(4):2235-46
(Latest) J:191065 Kang M, et al., FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse. Development. 2013 Jan;140(2):267-79
All references(373)

Other accession IDs

MGD-MRK-10001, MGD-MRK-10005