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Gata4
Gene Detail
 Symbol
Name
ID
Gata4
GATA binding protein 4
MGI:95664
Synonyms Gata-4
Feature Type protein coding gene
Genetic Map
Chromosome 14
33.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:63198922-63271692 bp, - strand
From VEGA annotation of GRCm38

  72771 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor GATA-4/5/6 types
Gene Tree: Gata4

Human
homologs
Human Homolog GATA4, GATA binding protein 4
NCBI Gene ID 2626
neXtProt AC  NX_P43694
Human Synonyms  ASD2, TACHD, VSD1
Human Chr (Location)  8p23.1-p22; chr8:11676924-11760001 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human GATA4
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(2) Targeted(15) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit defects in ventral morphogenesis, lack a primitive heart tube and foregut, develop partially outside the yolk sac, and die by midgestation.
 
Human Diseases Modeled Using Mouse Gata4 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(12)
Interactions
Gata4 interacts with 214 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (135 annotations)
Process atrial septum morphogenesis, atrial septum primum morphogenesis, ...
Component nuclear chromatin, nucleus
Function activating transcription factor binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (295 records)
Data Summary: Results (458)    Tissues (194)    Images (126)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 60
RNA in situ 250
Northern blot 22
Western blot 4
RT-PCR 122
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) Genomic(4) cDNA(39) Primer pair(15) Other(7)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000032593 (Evidence)
Ensembl Gene ModelENSMUSG00000021944 (Evidence)
Entrez Gene14463 (Evidence)
UniGene247669
DFCITC1582407
DoTSDT.110768372, DT.530169
NIA Mouse Gene IndexU035668
Consensus CDS ProjectCCDS49519.1
International Mouse Knockout Project StatusGata4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032593 VEGA Gene Model | MGI Sequence Detail 72771 C57BL/6J ±  kb
transcript OTTMUST00000081055 VEGA | MGI Sequence Detail 3400 Not Applicable 
polypeptide OTTMUSP00000043285 VEGA | MGI Sequence Detail 442 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(4) UniProt(6)
Polymorphisms RFLP(2) : SNPs within 2kb(214 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008013 GATA-type transcription activator, N-terminal
InterPro IPR016375 Transcription factor GATA-4/5/6
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000007859 transcription factor GATA-4
References (Earliest) J:4641 Arceci RJ, et al., Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993 Apr;13(4):2235-46
(Latest) J:212362 Sartori DJ, et al., GATA factors promote ER integrity and beta-cell survival and contribute to type 1 diabetes risk. Mol Endocrinol. 2014 Jan;28(1):28-39
All references(405)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10001, MGD-MRK-10005

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory