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Gata4
Gene Detail
Symbol

Name
ID
Gata4
GATA binding protein 4
MGI:95664
Synonyms
Gata-4
Feature Type
protein coding gene
Genetic Map
Chromosome 14
33.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:63198922-63271692 bp, - strand
From VEGA annotation of GRCm38

  72771 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1551  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GATA4
Protein SuperFamily: transcription factor GATA-4/5/6 types
Gene Tree: Gata4

Human
homologs
GATA4, GATA binding protein 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2626
neXtProt AC: NX_P43694

Human Synonyms: ASD2, TACHD, TOF, VSD1

Human Chr (Location): 8p23.1-p22; chr8:11676924-11760001 (+)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human GATA4

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(2) Targeted(15) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit defects in ventral morphogenesis, lack a primitive heart tube and foregut, develop partially outside the yolk sac, and die by midgestation.
 
Human Diseases Modeled in Mice Using Gata4 (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(12)
Interactions
Gata4 interacts with 214 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (139 annotations)
Process atrial septum morphogenesis, atrial septum primum morphogenesis, ...
Component nuclear chromatin, nucleus, ...
Function activating transcription factor binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (318 records)
Data Summary: Results (538)    Tissues (220)    Images (148)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 72
RNA in situ 272
Northern blot 22
Western blot 4
RT-PCR 168
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GATA4 ; Xenbase gata4 ; ZFIN gata4    NEW 
Molecular
reagents
All nucleic(72) Genomic(4) cDNA(41) Primer pair(19) Other(8)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000032593 (Evidence)
Ensembl Gene Model ENSMUSG00000021944 (Evidence)
Entrez Gene 14463 (Evidence)
UniGene 247669
DFCI TC1582407
DoTS DT.110768372, DT.530169
NIA Mouse Gene Index U035668
Consensus CDS Project CCDS49519.1
International Mouse Phenotyping Consortium Status Gata4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032593 VEGA Gene Model | MGI Sequence Detail 72771 C57BL/6J ±  kb
transcript OTTMUST00000081055 VEGA | MGI Sequence Detail 3400 Not Applicable 
polypeptide OTTMUSP00000043285 VEGA | MGI Sequence Detail 442 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(8) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(214 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008013 GATA-type transcription activator, N-terminal
InterPro IPR016375 Transcription factor GATA-4/5/6
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000007859 transcription factor GATA-4
References
(Earliest) J:4641 Arceci RJ, et al., Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993 Apr;13(4):2235-46
(Latest) J:222045 Padua MB, et al., Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes. Endocrinology. 2015 May;156(5):1873-86
All references(429)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10001, MGD-MRK-10005

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory