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Gata4 Gene Detail
Summary
  • Symbol
    Gata4
  • Name
    GATA binding protein 4
  • Synonyms
    Gata-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95664
    NCBI Gene: 14463
  • Gene Overview
    MyGene.info: GATA4
Location & Maps
more
  • Sequence Map
    Chr14:63198922-63271692 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72771 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.24 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GATA4, GATA binding protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GATA4, GATA binding protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASD2, TACHD, TOF, VSD1
  • Links
    NCBI Gene ID: 2626
    neXtProt AC: NX_P43694

  • Chr Location
    8p23.1-p22; chr8:11676924-11760001 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Gata4 mouse models; 5 with human GATA4 associations

Human Disease Mouse Models
       Atrial Septal Defect 2; ASD2   OMIM: 607941 View 1 model
       Diaphragmatic Hernia, Congenital   OMIM: 142340 View 2 models
       Atrioventricular Septal Defect 4; AVSD4   OMIM: 614430
Testicular Anomalies with or without Congenital Heart Disease; TACHD   OMIM: 615542
Tetralogy of Fallot; TOF   OMIM: 187500
Ventricular Septal Defect 1; VSD1   OMIM: 614429
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    99 phenotypes from 11 alleles in 14 genetic backgrounds
    56 phenotypes from multigenic genotypes
    12 images
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    16
  • Transgenic
    3
  • Genomic Mutations
    1 involving Gata4
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit defects in ventral morphogenesis, lack a primitive heart tube and foregut, develop partially outside the yolk sac, and die by midgestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032593 VEGA Gene Model | MGI Sequence Detail 72771 C57BL/6J ±  kb
transcript OTTMUST00000081055 VEGA | MGI Sequence Detail 3400 Not Applicable  
polypeptide OTTMUSP00000043285 VEGA | MGI Sequence Detail 442 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    213 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000007859 transcription factor GATA-4
  • InterPro Domains
    IPR008013 GATA-type transcription activator, N-terminal
    IPR016375 Transcription factor GATA-4/5/6
    IPR028436 Transcription factor GATA-4/GATA-binding factor A
    IPR000679 Zinc finger, GATA-type
    IPR013088 Zinc finger, NHR/GATA-type
Molecular
Reagents
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  • All nucleic 71
    Genomic 4
    cDNA 41
    Primer pair 19
    Other 7

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10001, MGD-MRK-10005
References
more
  • Summaries
    All 456
    Developmental Gene Expression 342
    Diseases 3
    Gene Ontology 65
    Phenotypes 89
  • Earliest
    J:4641 Arceci RJ, et al., Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993 Apr;13(4):2235-46
  • Latest
    J:231798 Chen CY, et al., Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 May 14;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory