55 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Arb2aTg(Tyr)TpNpin/Arb2aTg(Tyr)TpNpin Gata4tm1(cre)Svs/Gata4+ involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal neural crest cell migration	J:260599
Atoh8tm1.1Mlkn/Atoh8tm1.1Mlkn Gata4tm1.1Sad/Gata4+ Nkx2-5tm1(cre)Rjs/Nkx2-5+ involves: 129 * C57BL/6	normal mortality/aging	J:203454
Atoh8tm1.1Mlkn/Atoh8tm1.1Mlkn Gata4tm1Jml/Gata4+ involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6	normal cardiovascular system phenotype	J:203454
	lethality during fetal growth through weaning, incomplete penetrance	J:203454
	normal respiratory system phenotype	J:203454
Gata4tm1.1Jmol/Gata4tm1.1Jmol Tg(Myh6-Map2k1*)1Jmol/0 involves: 129 * C57BL/6 * FVB	abnormal heart size	J:174537
Gata4tm1.1Sad/Gata4+ Gata6tm2.1Sad/Gata6tm2.1Sad Tg(Wt1-cre)1Jbeb/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal heart layer morphology	J:206877
	preweaning lethality, incomplete penetrance	J:206877
Gata4tm1.1Sad/Gata4+ Glyr1em1Dsr/Glyr1+ Tg(Tek-cre)1Ywa/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL	lethality throughout fetal growth and development, incomplete penetrance	J:322763
	postnatal lethality, incomplete penetrance	J:322763
	ventricular septal defect	J:322763
Gata4tm1.1Sad/Gata4tm1.1Sad Gata6tm2.1Sad/Gata6+ Tg(Wt1-cre)1Jbeb/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal heart layer morphology	J:206877
	preweaning lethality, incomplete penetrance	J:206877
Gata4tm1.1Sad/Gata4tm1.1Sad Gata6tm2.1Sad/Gata6tm2.1Sad Tg(Wt1-cre)1Jbeb/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal cardiovascular development	J:206877
	abnormal heart layer morphology	J:206877
	decreased fetal cardiomyocyte proliferation	J:206877
	lethality throughout fetal growth and development, complete penetrance	J:206877
	polydactyly	J:206877
	thin myocardium	J:206877
	thin ventricular wall	J:206877
Gata4tm1.1Sad/Gata4tm1.1Sad Tg(Myh6-Map2k1*)1Jmol/0 involves: 129S1/Sv * 129X1/SvJ * FVB	cardiac hypertrophy	J:174537
Gata4tm1.1Sad/Gata4tm1.1Sad Tg(Myh6-Map2k1*)1Jmol/0 Tg(Myh7-cre)1Jmk/0 involves: 129S1/Sv * 129X1/SvJ * FVB	abnormal heart size	J:174537
Gata4tm1.1Sad/Gata4tm1.2Sad Pax3Sp-d/Pax3Sp-d Tg(Prrx1-cre)1Cjt/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J	normal muscle phenotype	J:231793
	normal respiratory system phenotype	J:231793
Gata4tm1.2Sad/Gata4tm1.2Sad Gata6tm3.1Sad/Gata6tm3.1Sad involves: 129	abnormal cardiogenic mesoderm morphology	J:135185
	abnormal fetal cardiomyocyte morphology	J:135185
	absent heart	J:135185
	absent heart tube	J:135185
Gata4tm1Eno/Gata4+ Gata6tm1Eno/Gata6+ involves: 129/Sv * 129S7/SvEvBrd * C57BL/6	abnormal aorta morphology	J:111824
	abnormal aorta smooth muscle morphology	J:111824
	abnormal blood vessel morphology	J:111824
	abnormal cardiac outflow tract development	J:111824
	abnormal fetal cardiomyocyte proliferation	J:111824
	abnormal interventricular septum morphology	J:111824
	abnormal vascular smooth muscle morphology	J:111824
	aorta hypoplasia	J:111824
	aortic arch hypoplasia	J:111824
	decreased erythrocyte cell number	J:111824
	dilated aorta	J:111824
	edema	J:111824
	embryonic lethality during organogenesis, complete penetrance	J:111824
	hemorrhage	J:111824
	irregular heartbeat	J:111824
	persistent truncus arteriosus	J:111824
	small liver	J:111824
	thin myocardium	J:111824
	thin myocardium compact layer	J:111824
	ventricular septal defect	J:111824
Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	sinus venosus atrial septal defect	J:155855
	thin myocardium compact layer	J:155855
	thin ventricle myocardium compact layer	J:155855
Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5tm1Eem involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal heart left ventricle outflow tract morphology	J:155855
	abnormal heart right ventricle outflow tract morphology	J:155855
	abnormal trabecula carnea morphology	J:155855
	atrioventricular cushion hypoplasia	J:155855
	complete atrioventricular septal defect	J:155855
	congestive heart failure	J:155855
	conotruncal ridge hypoplasia	J:155855
	decreased fetal cardiomyocyte proliferation	J:155855
	edema	J:155855
	hemorrhage	J:155855
	inlet ventricular septal defect	J:155855
	lethality throughout fetal growth and development, complete penetrance	J:155855
	ostium primum atrial septal defect	J:155855
	thin ventricle myocardium compact layer	J:155855
	thin ventricular wall	J:155855
	unbalanced complete common atrioventricular canal	J:155855
	ventricular myocardium compact layer hypoplasia	J:155855
Gata4tm1Sho/Gata4tm1Sho Gata6tm1Kgac/Gata6tm1Kgac involves: 129S1/Sv * 129S6/SvEvTac	abnormal lung development	J:134027