Gata6^tm2.1Sad
Targeted Allele Detail

Summary

• Symbol: Gata6^tm2.1Sad
• Name: GATA binding protein 6; targeted mutation 2.1, Stephen A Duncan
• MGI ID: MGI:3654150
• Synonyms: Gata6 floxed, Gata6^loxP
• Gene: Gata6 Location: Chr18:11052510-11085636 bp, + strand Genetic Position: Chr18, 5.63 cM
• Alliance: Gata6^tm2.1Sad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111388
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A pair of loxP sequences are located in the first and second introns, flanking exon 2. A single FRT sequence is present immediately downstream of the more 5' loxP as a consequence of the removal of an frt-flanked neomycin seletion cassette. (J:111388)

Expression

In Mice Carrying this Mutation:

66 assay results 6 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gata6 Mutation: 32 strains or lines available

Notes

This allele was derived by deletion of an FRT-flanked neomycin phosphotransferase gene that in the original construct lay just downstream of the 5' loxP site. Mice homozygous for the neo-containing allele could not be recovered from heterozygous matings. (J:111388)

References

• Original: J:111388 Sodhi CP, et al., Generation of mice harbouring a conditional loss-of-function allele of Gata6. BMC Dev Biol. 2006;6:19
• All: 58 reference(s)