Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation
(1 available);
any
Gata6 mutation
(32 available)
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normal phenotype
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• viable and fertile with no gross malformations
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation
(1 available);
any
Gata6 mutation
(32 available)
Gata6tm2.2Sad mutation
(0 available);
any
Gata6 mutation
(32 available)
Tg(EIIa-cre)C5379Lmgd mutation
(4 available)
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mortality/aging
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• between E8.5 and E11.5 all Cre positive double mutants appear to be partially resorbed empty decidual masses
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation
(1 available);
any
Gata6 mutation
(32 available)
Tg(Vil1-cre)997Gum mutation
(2 available)
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mortality/aging
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• matings of 4 of 5 males carrying the Cre transgene to homozygous females produced no offspring homozygous for the floxed allele and Cre positive
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation
(1 available);
any
Gata4 mutation
(36 available)
Gata6tm2.1Sad mutation
(1 available);
any
Gata6 mutation
(32 available)
Tg(Wt1-cre)1Jbeb mutation
(0 available)
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mortality/aging
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• mutants are viable through E15.5, with a small number recovered at weaning
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cardiovascular system
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• a statistically significant decrease in sub-epicardicardial endothelial cells is observed at E13.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation
(1 available);
any
Gata4 mutation
(36 available)
Gata6tm2.1Sad mutation
(1 available);
any
Gata6 mutation
(32 available)
Tg(Wt1-cre)1Jbeb mutation
(0 available)
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mortality/aging
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• mutants are viable through E15.5, with a small number recovered at weaning
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cardiovascular system
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• a statistically significant decrease in sub-epicardicardial endothelial cells is observed at E13.5
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Sad mutation
(1 available);
any
Gata4 mutation
(36 available)
Gata6tm2.1Sad mutation
(1 available);
any
Gata6 mutation
(32 available)
Tg(Wt1-cre)1Jbeb mutation
(0 available)
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mortality/aging
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• normal Mendelian ratios are observed through E14.5, but all mutants are necrotic by E15.5; no living animals are present at weaning
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cardiovascular system
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• at E13.5, hearts display some coronary plexus formation near the base with significantly vessel decreased spreading towards the apex
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• numbers of sub-epicardial endothelial cells are decreased by <90% at E13.5 compared to wild-type
• numbers of epicardial cells are not different from wild type at E13.5
• 3-fold fewer inner-myocardial endothelial cells are detected in mutant hearts at E13.5
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• one third of E13.5 hearts display myocardial thinning (<2 SD from mean of wild-type)
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• mutants show decreased ventricular thickness compared to wild-type
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• at E13.5, myocardial proliferation is decreased compared to wild-type, contribution to the observed myocardial thinning
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limbs/digits/tail
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• hind limb polydactyly is observed in E14.5 embryos
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cellular
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• at E13.5, myocardial proliferation is decreased compared to wild-type, contribution to the observed myocardial thinning
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muscle
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• one third of E13.5 hearts display myocardial thinning (<2 SD from mean of wild-type)
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• at E13.5, myocardial proliferation is decreased compared to wild-type, contribution to the observed myocardial thinning
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation
(1 available);
any
Gata6 mutation
(32 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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limbs/digits/tail
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• 100% penetrance of preaxial hindlimb polydactyly with a variable number of supernumerary digits
• forelimb digits are not affected
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2.1Sad mutation
(1 available);
any
Gata6 mutation
(32 available)
Gli1tm1Alj mutation
(0 available);
any
Gli1 mutation
(48 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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limbs/digits/tail
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• hindlimbs have four digits
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