Gata6^tm1Kgac
Targeted Allele Detail

Summary

• Symbol: Gata6^tm1Kgac
• Name: GATA binding protein 6; targeted mutation 1, Kate G Ackerman
• MGI ID: MGI:3785386
• Synonyms: Gata6^ki
• Gene: Gata6 Location: Chr18:11052510-11085636 bp, + strand Genetic Position: Chr18, 5.63 cM
• Alliance: Gata6^tm1Kgac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134027
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exons 5 were replaced with an exon 5 containing a missense mutation that resulted in an amino acid substitution of glycine for valine at position 239 (V239G) and a floxed neo cassette up stream of exon 5. Transient cre expression in ES cells was used to remove the neo cassette. This allele produces a truncated transcript. (J:134027)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata6 Mutation: 32 strains or lines available

References

• Original: J:134027 Ackerman KG, et al., Gata4 is necessary for normal pulmonary lobar development. Am J Respir Cell Mol Biol. 2007 Apr;36(4):391-7
• All: 1 reference(s)