About   Help   FAQ
G6pc Gene Detail
Summary
  • Symbol
    G6pc
  • Name
    glucose-6-phosphatase, catalytic
  • Synonyms
    G6Pase, G6pt, Glc-6-Pase, Glc-6-Pase-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:95607
    NCBI Gene: 14377
  • Gene Overview
    MyGene.info: G6PC
Location & Maps
more
  • Sequence Map
    Chr11:101367561-101377903 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10343 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 64.83 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    G6PC, glucose-6-phosphatase catalytic subunit
  • Vertebrate Orthologs
    11
  • Human Ortholog
    G6PC, glucose-6-phosphatase catalytic subunit
    Orthology source: HomoloGene
  • Synonyms
    G6Pase, G6PC1, G6PT, GSD1, GSD1a
  • Links
    NCBI Gene ID: 2538
    neXtProt AC: NX_P35575

  • Chr Location
    17q21; chr17:42900797-42914433 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with G6pc mouse models; 1 with human G6PC associations

Human Disease Mouse Models
       Glycogen Storage Disease IA; GSD1A   OMIM: 232200 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 5 alleles in 4 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    8
  • Genomic Mutations
    1 involving G6pc
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene tend to die within a couple of weeks of weaning. Blood chemistry and glucose metabolism are abnormal as is glycogen storage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002811 VEGA Gene Model | MGI Sequence Detail 10343 C57BL/6J ±  kb
transcript OTTMUST00000005672 VEGA | MGI Sequence Detail 2414 Not Applicable  
polypeptide OTTMUSP00000002712 VEGA | MGI Sequence Detail 357 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    102 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007746 glucose-6-phosphatase
  • EC
  • InterPro Domains
    IPR016275 Glucose-6-phosphatase
    IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
Molecular
Reagents
less
  • All nucleic 53
    Genomic 1
    cDNA 47
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9916, MGI:2144495
References
more
  • Summaries
    All 80
    Developmental Gene Expression 22
    Diseases 4
    Gene Ontology 12
    Phenotypes 30
  • Earliest
    J:12701 Hanigan MH, et al., Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice. Carcinogenesis. 1993 May;14(5):1035-40
  • Latest
    J:225424 Kim GY, et al., Mice expressing reduced levels of hepatic glucose-6-phosphatase-alpha activity do not develop age-related insulin resistance or obesity. Hum Mol Genet. 2015 Sep 15;24(18):5115-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory