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G6pc
Gene Detail
 Symbol
Name
ID
G6pc
glucose-6-phosphatase, catalytic
MGI:95607
Synonyms G6Pase, G6pt, Glc-6-Pase, Glc-6-Pase-alpha
Feature Type protein coding gene
Genetic Map
Chromosome 11
64.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:101367561-101377903 bp, + strand
From VEGA annotation of GRCm38

  10343 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glucose-6-phosphatase
Gene Tree: G6pc

Human
homologs
Human Homolog G6PC, glucose-6-phosphatase, catalytic subunit
NCBI Gene ID 2538
neXtProt AC  NX_P35575
Human Synonyms  G6PC1, G6PT, GSD1, GSD1a
Human Chr (Location)  17q21; chr17:42900797-42914433 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human G6PC
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene tend to die within a couple of weeks of weaning. Blood chemistry and glucose metabolism are abnormal as is glycogen storage.
 
Human Diseases Modeled Using Mouse G6pc (1)    Alleles Annotated to Human Diseases(3)   
Interactions
G6pc interacts with 187 markers (Mir7-1, Mir15b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cholesterol homeostasis, dephosphorylation, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function catalytic activity, glucose-6-phosphatase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (152)    Tissues (111)    Images (3)
Theiler Stages: 22, 24, 25, 26, 28
Assay TypeResults
RNA in situ 94
Northern blot 43
RT-PCR 15
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) Genomic(1) cDNA(47) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002811 (Evidence)
Ensembl Gene ModelENSMUSG00000078650 (Evidence)
Entrez Gene14377 (Evidence)
UniGene18064
DFCITC1579880
DoTSDT.531937
NIA Mouse Gene IndexU013366
EC3.1.3.9
Consensus CDS ProjectCCDS25466.1
International Mouse Knockout Project StatusG6pc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002811 VEGA Gene Model | MGI Sequence Detail 10343 C57BL/6J ±  kb
transcript OTTMUST00000005672 VEGA | MGI Sequence Detail 2414 Not Applicable 
polypeptide OTTMUSP00000002712 VEGA | MGI Sequence Detail 357 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016275 Glucose-6-phosphatase
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
Protein Ontology PR:000007746 glucose-6-phosphatase
References (Earliest) J:12701 Hanigan MH, et al., Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice. Carcinogenesis. 1993 May;14(5):1035-40
(Latest) J:206793 Kheradpezhouh E, et al., TRPM2 channels mediate acetaminophen-induced liver damage. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3176-81
All references(80)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-9916, MGI:2144495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory