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G6pc
Gene Detail
Symbol

Name
ID
G6pc
glucose-6-phosphatase, catalytic
MGI:95607
Synonyms
G6Pase, G6pt, Glc-6-Pase, Glc-6-Pase-alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 11
64.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:101367561-101377903 bp, + strand
From VEGA annotation of GRCm38

  10343 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: G6PC
Protein SuperFamily: glucose-6-phosphatase
Gene Tree: G6pc

Human
homologs
G6PC, glucose-6-phosphatase, catalytic subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2538
neXtProt AC: NX_P35575

Human Synonyms: G6PC1, G6PT, GSD1, GSD1a

Human Chr (Location): 17q21; chr17:42900797-42914433 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human G6PC

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving G6pc (1)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene tend to die within a couple of weeks of weaning. Blood chemistry and glucose metabolism are abnormal as is glycogen storage.
 
Human Diseases Modeled in Mice Using G6pc (1)    Mutations Annotated to Human Diseases (3)   
Interactions
G6pc interacts with 186 markers (Mir7-1, Mir15b, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (21 records)
Data Summary: Results (152)    Tissues (113)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 43
RT-PCR 15
cDNA source data(46)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase g6pc ; ZFIN g6pca.1, g6pca.2    NEW 
Molecular
reagents
All nucleic(53) Genomic(1) cDNA(47) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002811 (Evidence)
Ensembl Gene Model ENSMUSG00000078650 (Evidence)
Entrez Gene 14377 (Evidence)
UniGene 18064
DFCI TC1579880
DoTS DT.531937
NIA Mouse Gene Index U013366
EC 3.1.3.9
Consensus CDS Project CCDS25466.1
International Mouse Phenotyping Consortium Status G6pc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002811 VEGA Gene Model | MGI Sequence Detail 10343 C57BL/6J ±  kb
transcript OTTMUST00000005672 VEGA | MGI Sequence Detail 2414 Not Applicable 
polypeptide OTTMUSP00000002712 VEGA | MGI Sequence Detail 357 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016275 Glucose-6-phosphatase
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
Protein Ontology PR:000007746 glucose-6-phosphatase
References
(Earliest) J:12701 Hanigan MH, et al., Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice. Carcinogenesis. 1993 May;14(5):1035-40
(Latest) J:220983 Soty M, et al., A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health. Mol Metab. 2015 Feb;4(2):106-17
All references(81)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-9916, MGI:2144495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory