G6pc
Gene Detail

Symbol Name ID

G6pc glucose-6-phosphatase, catalytic MGI:95607

Synonyms

G6Pase, G6pt, Glc-6-Pase, Glc-6-Pase-alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 11

64.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:101367561-101377903 bp, + strand From VEGA annotation of GRCm38   10343 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glucose-6-phosphatase
Gene Tree: G6pc

Human homologs

Human Homolog		G6PC, glucose-6-phosphatase, catalytic subunit
NCBI Gene ID		2538
neXtProt AC		NX_P35575
Human Synonyms		G6PC1, G6PT, GSD1, GSD1a
Human Chr (Location)		17q21; chr17:41052814-41066450 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human G6PC

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for disruptions in this gene tend to die within a couple of weeks of weaning. Blood chemistry and glucose metabolism are abnormal as is glycogen storage.

 
Human Diseases Modeled Using Mouse G6pc (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	cholesterol homeostasis, dephosphorylation, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	catalytic activity, glucose-6-phosphatase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (152)    Tissues (111)    Images (3)
Theiler Stages: 22, 24, 25, 26, 28

Assay Type	Results
RNA in situ	94
Northern blot	43
RT-PCR	15

cDNA source data(46)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) Genomic(1) cDNA(47) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002811 (Evidence)
Ensembl Gene Model	ENSMUSG00000078650 (Evidence)
Entrez Gene	14377 (Evidence)
UniGene	18064
DFCI	TC1579880
DoTS	DT.531937
NIA Mouse Gene Index	U013366
EC	3.1.3.9
Consensus CDS Project	CCDS25466.1
International Mouse Knockout Project Status	G6pc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002811	VEGA Gene Model | MGI Sequence Detail	10343	C57BL/6J
transcript	OTTMUST00000005672	VEGA | MGI Sequence Detail	2414	Not Applicable
polypeptide	OTTMUSP00000002712	VEGA | MGI Sequence Detail	357	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016275	Glucose-6-phosphatase
InterPro	IPR016118	Phosphatidic acid phosphatase/chloroperoxidase, N-terminal
InterPro	IPR000326	Phosphatidic acid phosphatase type 2/haloperoxidase
Protein Ontology	PR:000007746	glucose-6-phosphatase

References

(Earliest) J:12701 Hanigan MH, et al., Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice. Carcinogenesis. 1993 May;14(5):1035-40
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(72)

Other accession IDs

MGD-MRK-9916, MGI:2144495