G6pc1^tm1Jyc
Targeted Allele Detail

Summary

• Symbol: G6pc1^tm1Jyc
• Name: glucose-6-phosphatase catalytic subunit 1; targeted mutation 1, Janice Yang Chou
• MGI ID: MGI:2387343
• Synonyms: G6Pase-, Glc-6-Pase-alpha-
• Gene: G6pc1 Location: Chr11:101258542-101268729 bp, + strand Genetic Position: Chr11, 64.83 cM
• Alliance: G6pc1^tm1Jyc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33212
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neomycin selection cassette via homologous recombination. Neither transcript nor protein were detected in homozygous mutant mice by a protection assay and Western blot analysis of liver and kidney tissues. Functional ablation was confirmed by the absence of glucose-6-phosphate hydrolysis in liver and kidney microsomes obtained from homozygous mutant mice. (J:33212)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any G6pc1 Mutation: 18 strains or lines available

References

• Original: J:33212 Lei KJ, et al., Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type-1a mouse. Nat Genet. 1996 Jun;13(2):203-9
• All: 18 reference(s)