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Erbb2
Gene Detail
Symbol

Name
ID
Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
MGI:95410
Synonyms
c-erbB2, c-neu, ErbB-2, HER2, HER-2, mKIAA3023, Neu, Neu oncogene
Feature Type
protein coding gene
Genetic Map
Chromosome 11
61.75 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr11:98412470-98437716 bp, + strand
From VEGA annotation of GRCm38

  25247 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3273  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ERBB2
Protein SuperFamily: tyrosine-protein kinase, EGF receptor type
Gene Tree: Erbb2

Human
homologs
ERBB2, erb-b2 receptor tyrosine kinase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2064
neXtProt AC: NX_P04626

Human Synonyms: CD340, HER2, HER-2, HER-2/neu, MLN 19, NEU, NGL, TKR1

Human Chr (Location): 17q12; chr17:39688084-39728662 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human ERBB2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Targeted(20) Transgenic(10)
Genomic Mutations involving Erbb2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit degeneration of motor nerves, an absence of Schwann cells, impairment of junctional folds at the neuromuscular synapse, and cardiac defects that results in lethality by embryonic day 10.5.
 
Human Diseases Modeled in Mice Using Erbb2 (1)    Mutations Annotated to Human Diseases (9)    Phenotype Images(2)
Interactions
Erbb2 interacts with 158 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (93 annotations)
Process cell surface receptor signaling pathway, estrous cycle, ...
Component apical plasma membrane, basal plasma membrane, ...
Function ATP binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (61 records)
Data Summary: Results (448)    Tissues (153)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 333
Western blot 38
RT-PCR 54
RNase protection 8
cDNA source data(84)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ERBB2 ; Xenbase erbb2 ; ZFIN erbb2    NEW 
Molecular
reagents
All nucleic(95) Genomic(3) cDNA(88) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002711 (Evidence)
Ensembl Gene Model ENSMUSG00000062312 (Evidence)
Entrez Gene 13866 (Evidence)
UniGene 290822
DFCI TC1592977, TC1596696, TC1597081, TC1606213
NIA Mouse Gene Index U013298
EC 2.7.10.1
Consensus CDS Project CCDS25349.1
International Mouse Phenotyping Consortium Status Erbb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002711 VEGA Gene Model | MGI Sequence Detail 25247 C57BL/6J ±  kb
transcript OTTMUST00000005365 VEGA | MGI Sequence Detail 5012 Not Applicable 
polypeptide OTTMUSP00000002540 VEGA | MGI Sequence Detail 1256 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(3) UniProt(4)
Polymorphisms
RFLP(8) : SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000494 EGF receptor, L domain
InterPro IPR006211 Furin-like cysteine-rich domain
InterPro IPR006212 Furin-like repeat
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Protein Ontology PR:000002082 receptor tyrosine-protein kinase erbB-2
References
(Earliest) J:32779 Schechter AL, et al., The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature. 1984 Dec 6-12;312(5994):513-6
(Latest) J:219654 Liu X, et al., ErbB receptor-driven prolactinomas respond to targeted lapatinib treatment in female transgenic mice. Endocrinology. 2015 Jan;156(1):71-9
All references(245)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-9571, MGD-MRK-9573

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory