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Erbb2 Gene Detail
Summary
  • Symbol
    Erbb2
  • Name
    erb-b2 receptor tyrosine kinase 2
  • Synonyms
    c-erbB2, c-neu, ErbB-2, HER2, HER-2, l11Jus8, mKIAA3023, Neu, Neu oncogene
  • Feature Type
    protein coding gene
  • IDs
    MGI:95410
    NCBI Gene: 13866
  • Gene Overview
    MyGene.info: ERBB2
Location & Maps
more
  • Sequence Map
    Chr11:98412470-98437716 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25247 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.75 cM, cytoband D
  • Mapping Data
    27 experiments
Homology
more
  • Human Ortholog
    ERBB2, erb-b2 receptor tyrosine kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ERBB2, erb-b2 receptor tyrosine kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD340, HER2, HER-2, HER-2/neu, MLN 19, NEU, NGL, TKR1
  • Links
    NCBI Gene ID: 2064
    neXtProt AC: NX_P04626

  • Chr Location
    17q12; chr17:39688084-39728662 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Erbb2 mouse models; 3 with human ERBB2 associations

Human Disease Mouse Models
       Breast Cancer   OMIM: 114480 View 18 models
       Gastric Cancer   OMIM: 613659
Glioma Susceptibility 1; GLM1   OMIM: 137800
Lung Cancer   OMIM: 211980
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    13 with disease annotations
  • References
    33 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    105 phenotypes from 19 alleles in 18 genetic backgrounds
    76 phenotypes from multigenic genotypes
    2 images
    449 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    56
  • Chemically induced (ENU)
    1
  • Targeted
    20
  • Transgenic
    35
  • Genomic Mutations
    1 involving Erbb2
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit degeneration of motor nerves, an absence of Schwann cells, impairment of junctional folds at the neuromuscular synapse, and cardiac defects that results in lethality by embryonic day 10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002711 VEGA Gene Model | MGI Sequence Detail 25247 C57BL/6J ±  kb
transcript OTTMUST00000005365 VEGA | MGI Sequence Detail 5012 Not Applicable  
polypeptide OTTMUSP00000002540 VEGA | MGI Sequence Detail 1256 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    151 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000002082 receptor tyrosine-protein kinase erbB-2
  • EC
  • InterPro Domains
    IPR006211 Furin-like cysteine-rich domain
    IPR006212 Furin-like repeat
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR032778 Growth factor receptor domain 4
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR000494 Receptor L-domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Molecular
Reagents
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  • All nucleic 95
    Genomic 3
    cDNA 88
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-9571, MGD-MRK-9573, MGI:2671273
References
more
  • Summaries
    All 255
    Developmental Gene Expression 63
    Diseases 33
    Gene Ontology 24
    Phenotypes 449
  • Earliest
    J:32779 Schechter AL, et al., The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature. 1984 Dec 6-12;312(5994):513-6
  • Latest
    J:229476 Creedon H, et al., Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer. Dis Model Mech. 2016 Feb 1;9(2):131-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory