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Erbb2 Gene Detail
Summary
  • Symbol
    Erbb2
  • Name
    erb-b2 receptor tyrosine kinase 2
  • Synonyms
    c-erbB2, c-neu, ErbB-2, HER2, HER-2, l11Jus8, mKIAA3023, Neu, Neu oncogene
  • Feature Type
    protein coding gene
  • IDs
    MGI:95410
    NCBI Gene: 13866
  • Gene Overview
    MyGene.info: ERBB2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:98412470-98437716 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25247 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.75 cM, cytoband D
  • Mapping Data
    27 experiments
Homology
more
  • Human Ortholog
    ERBB2, erb-b2 receptor tyrosine kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ERBB2, erb-b2 receptor tyrosine kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD340, HER2, HER-2, HER-2/neu, MLN 19, NEU, NGL, TKR1
  • Links
    NCBI Gene ID: 2064
    neXtProt AC: NX_P04626
    UniProt: P04626

  • Chr Location
    17q12; chr17:39688084-39728662 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Erbb2 mouse models; 3 with human ERBB2 associations

Human Disease Mouse Models
      
IDs
View 21 models
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    21 with disease annotations
  • References
    20 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    105 phenotypes from 19 alleles in 18 genetic backgrounds
    87 phenotypes from multigenic genotypes
    2 images
    520 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit degeneration of motor nerves, an absence of Schwann cells, impairment of junctional folds at the neuromuscular synapse, and cardiac defects that results in lethality by embryonic day 10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002711 VEGA Gene Model | MGI Sequence Detail 25247 C57BL/6J ±  kb
    transcript OTTMUST00000005365 VEGA | MGI Sequence Detail 5012 Not Applicable  
    polypeptide OTTMUSP00000002540 VEGA | MGI Sequence Detail 1256 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      151 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      Genomic 3
      cDNA 93
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9571, MGD-MRK-9573, MGI:2671273
    References
    more
    • Summaries
      All 740
      Developmental Gene Expression 75
      Diseases 20
      Gene Ontology 26
      Phenotypes 520
    • Earliest
      J:32779 Schechter AL, et al., The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature. 1984 Dec 6-12;312(5994):513-6
    • Latest
      J:264380 Artap S, et al., Endocardial Hippo signaling regulates myocardial growth and cardiogenesis. Dev Biol. 2018 Aug 1;440(1):22-30

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory