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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Erbb2
erb-b2 receptor tyrosine kinase 2
MGI:95410
46 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dock1tm2.1Jfco/Dock1+
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: C57BL/6 * FVB/NJ 		increased mammary adenocarcinoma incidence J:196659
increased mammary gland tumor incidence J:196659
increased tumor latency J:196659
Dock1tm2.1Jfco/Dock1tm2.1Jfco
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: C57BL/6 * FVB/NJ 		decreased cell proliferation J:196659
decreased metastatic potential J:196659
decreased tumor growth/size J:196659
increased apoptosis J:196659
increased mammary adenocarcinoma incidence J:196659
increased mammary gland tumor incidence J:196659
increased tumor latency J:196659
Erbb2tm1Cbm/Erbb2+
Nrg1tm1Cbm/Nrg1+
involves: 129P2/OlaHsd 		abnormal myelination J:90038
abnormal nerve conduction J:90038
Erbb2tm1Cbm/Erbb2+
Erbb3tm2Cbm/Erbb3+
Nrg1tm1Cbm/Nrg1+
involves: 129P2/OlaHsd 		abnormal myelination J:90038
abnormal nerve conduction J:90038
Erbb2tm1Haus/Erbb2tm1Klee
Gfra1tm3Jmi/Gfra1+
Myf5tm3(cre)Sor/Myf5+
involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ 		abnormal cholinergic neuron morphology J:160727
decreased motor neuron number J:160727
Erbb2tm1Mll/Erbb2tm1Mll
Erbb4tm1Fej/Erbb4tm1Fej
Tg(Gabra6-cre)CWwis/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		normal nervous system phenotype J:145947
Erbb2tm3(Erbb2)Mul/Erbb2tm1Mll
Tg(ACTA1-cre)1Mll/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal CNS synaptic transmission J:82801
abnormal motor capabilities/coordination/movement J:82801
abnormal muscle spindle morphology J:82801
abnormal neuromuscular synapse morphology J:82801
abnormal reflex J:82801
absent muscle spindles J:82801
ataxia J:82801
Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
involves: 129S1/Sv * 129X1/SvJ 		absent primary muscle spindle J:81565
partial loss of secondary muscle spindle J:81565
Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Tg(Ckmm-cre)5Khn/0
involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB 		abnormal gait J:81565
abnormal limb posture J:81565
abnormal posture J:81565
absent primary muscle spindle J:81565
absent secondary muscle spindle J:81565
cachexia J:81565
impaired coordination J:81565
impaired limb coordination J:81565
impaired skeletal muscle regeneration J:81565
increased myoblast apoptosis J:81565
malocclusion J:81565
premature death J:81565
Erbb2tm4(Erbb2)Mul/Erbb2tm1Haus
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c 		abnormal phrenic nerve innervation pattern to diaphragm J:94397
abnormal phrenic nerve morphology J:94397
abnormal sympathetic ganglion morphology J:94397
cyanosis J:94397
defasiculated phrenic nerve J:94397
perinatal lethality, complete penetrance J:94397
respiratory failure J:94397
Erbb2tm4(Erbb2)Mul/Erbb2tm4(Erbb2)Mul
involves: 129S1/Sv * 129X1/SvJ * BALB/c 		no abnormal phenotype detected J:94397
Erbb2tm5(Erbb2)Mul/Erbb2tm1Haus
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c 		no abnormal phenotype detected J:94397
Erbb2tm5(Erbb2)Mul/Erbb2tm5(Erbb2)Mul
involves: 129S1/Sv * 129X1/SvJ * BALB/c 		no abnormal phenotype detected J:94397
Erbb2tm6(Erbb2)Mul/Erbb2tm1Haus
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c 		abnormal phrenic nerve innervation pattern to diaphragm J:94397
abnormal phrenic nerve morphology J:94397
defasiculated phrenic nerve J:94397
perinatal lethality, complete penetrance J:94397
respiratory failure J:94397
Erbb2tm6(Erbb2)Mul/Erbb2tm6(Erbb2)Mul
involves: 129S1/Sv * 129X1/SvJ * BALB/c 		no abnormal phenotype detected J:94397
Erbb2tm7(Erbb2)Mul/Erbb2tm1Haus
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c 		abnormal phrenic nerve innervation pattern to diaphragm J:94397
abnormal phrenic nerve morphology J:94397
defasiculated phrenic nerve J:94397
perinatal lethality, complete penetrance J:94397
respiratory failure J:94397
Erbb2tm7(Erbb2)Mul/Erbb2tm7(Erbb2)Mul
involves: 129S1/Sv * 129X1/SvJ * BALB/c 		abnormal sensory neuron morphology J:94397
Erbb2tm8(Erbb2)Mul/Erbb2+
Ptentm1Hwu/Pten+
Tg(MMTV-cre)7Mul/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N 		increased mammary gland tumor incidence J:133305
increased metastatic potential J:133305
Erbb2tm8(Erbb2)Mul/Erbb2+
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)7Mul/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N 		increased mammary gland tumor incidence J:133305
Shc1tm9Paw/Shc1tm9Paw
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal mammary gland morphology J:133325
normal neoplasm J:133325
normal reproductive system phenotype J:133325
Stat1tm1Mam/Stat1tm1Mam
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: 129S/SvEv * FVB 		decreased tumor latency J:169262
Stk11tm1Rdp/Stk11tm1Rdp
Tg(MMTV-Erbb2*,-cre)1Mul/0
involves: 129S6/SvEvTac * C57BL/6 		abnormal mammary gland morphology J:198481
decreased tumor latency J:198481
increased mammary gland tumor incidence J:198481
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory