Ctla4
Gene Detail

Symbol Name ID

Ctla4 cytotoxic T-lymphocyte-associated protein 4 MGI:88556

Synonyms

Cd152, Ctla-4, Ly-56

Feature Type

protein coding gene

Genetic Map

Chromosome 1

30.58 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(46)

Sequence Map

Chr1:60887000-60915832 bp, + strand From VEGA annotation of GRCm38   28833 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3820  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: T-cell surface glycoprotein CD28
Gene Tree: Ctla4

Human homologs

Human Homolog		CTLA4, cytotoxic T-lymphocyte-associated protein 4
NCBI Gene ID		1493
neXtProt AC		NX_P16410
Human Synonyms		CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Human Chr (Location)		2q33; chr2:204732511-204738683 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human CTLA4

Alleles and phenotypes

All alleles(12) : Targeted(11) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit lethality at 3 to 4 weeks of age, decreased T cell numbers, abnormal T cell physiology, inflammation in mutliple organs, abnormal thymus morphology, and lymph node hypoplasia.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	B cell receptor signaling pathway, immune response, ...
Component	clathrin-coated endocytic vesicle, external side of plasma membrane, ...

External Resources: FuncBase

Expression

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(2) cDNA(18) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002278 (Evidence)
Ensembl Gene Model	ENSMUSG00000026011 (Evidence)
Entrez Gene	12477 (Evidence)
UniGene	390
DFCI	TC1584855, TC1758846
DoTS	DT.40181215, DT.99854682
NIA Mouse Gene Index	U000349
PDB	1DQT
Consensus CDS Project	CCDS14993.1
International Mouse Knockout Project Status	Ctla4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002278	VEGA Gene Model | MGI Sequence Detail	28833	C57BL/6J
transcript	OTTMUST00000004524	VEGA | MGI Sequence Detail	1933	Not Applicable
polypeptide	OTTMUSP00000002168	VEGA | MGI Sequence Detail	223	Not Applicable

All sequences(36) RefSeq(2) UniProt(6)

Polymorphisms

All PCR and RFLP(6) : PCR(1) RFLP(5) SNPs(56 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008096	Cytotoxic T-lymphocyte antigen 4
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000001852	cytotoxic T-lymphocyte protein 4

References

(Earliest) J:8775 Brunet JF, et al., A new member of the immunoglobulin superfamily--CTLA-4. Nature. 1987 Jul 16-22;328(6127):267-70
(Latest) J:193282 Verhagen J, et al., CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):E221-30
All references(219)

Other accession IDs

MGD-MRK-2224, MGD-MRK-2234