About   Help   FAQ
Ctla4
Gene Detail
 Symbol
Name
ID
Ctla4
cytotoxic T-lymphocyte-associated protein 4
MGI:88556
Synonyms Cd152, Ctla-4, Ly-56
Feature Type protein coding gene
Genetic Map
Chromosome 1
30.58 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(46)
Sequence Map
Chr1:60887000-60915832 bp, + strand
From VEGA annotation of GRCm38

  28833 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3820  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: T-cell surface glycoprotein CD28
Gene Tree: Ctla4

Human
homologs
Human Homolog CTLA4, cytotoxic T-lymphocyte-associated protein 4
NCBI Gene ID 1493
neXtProt AC  NX_P16410
Human Synonyms  CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Human Chr (Location)  2q33; chr2:203867788-203873960 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human CTLA4
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(1) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit lethality at 3 to 4 weeks of age, decreased T cell numbers, abnormal T cell physiology, inflammation in mutliple organs, abnormal thymus morphology, and lymph node hypoplasia.
 
Interactions
Ctla4 interacts with 191 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process B cell receptor signaling pathway, cellular response to DNA damage stimulus, ...
Component clathrin-coated endocytic vesicle, external side of plasma membrane, ...
External Resources: FuncBase
Expression
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(2) cDNA(18) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002278 (Evidence)
Ensembl Gene ModelENSMUSG00000026011 (Evidence)
Entrez Gene12477 (Evidence)
UniGene390
DFCITC1584855, TC1758846
DoTSDT.40181215, DT.99854682
NIA Mouse Gene IndexU000349
PDB1DQT
Consensus CDS ProjectCCDS14993.1, CCDS69893.1
International Mouse Knockout Project StatusCtla4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002278 VEGA Gene Model | MGI Sequence Detail 28833 C57BL/6J ±  kb
transcript OTTMUST00000004524 VEGA | MGI Sequence Detail 1933 Not Applicable 
polypeptide OTTMUSP00000002168 VEGA | MGI Sequence Detail 223 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(6)
Polymorphisms All PCR and RFLP(6) : PCR(1) RFLP(5) SNPs within 2kb(265 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008096 Cytotoxic T-lymphocyte antigen 4
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001852 cytotoxic T-lymphocyte protein 4
References (Earliest) J:8775 Brunet JF, et al., A new member of the immunoglobulin superfamily--CTLA-4. Nature. 1987 Jul 16-22;328(6127):267-70
(Latest) J:206884 Jain N, et al., CD28 and ITK signals regulate autoreactive T cell trafficking. Nat Med. 2013 Dec;19(12):1632-7
All references(223)
Other
accession IDs
MGD-MRK-2224, MGD-MRK-2234

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory