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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ctla4
cytotoxic T-lymphocyte-associated protein 4
MGI:88556
29 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd28tm1Shr/Cd28tm1Shr
Ctla4tm1Shr/Ctla4+
C.129S4-Cd28tm1Shr Ctla4tm1Shr 		abnormal CD8-positive, alpha beta T cell morphology J:125259
increased susceptibility to autoimmune disorder J:125259
Cd28tm1Shr/Cd28tm1Shr
Ctla4tm1Shr/Ctla4tm1Shr
C.129S4-Cd28tm1Shr Ctla4tm1Shr 		abnormal interferon level J:68642
abnormal interleukin secretion J:68642
decreased CD4-positive, alpha-beta T cell number J:68642
decreased T cell proliferation J:68642
increased length of allograft survival J:68642
Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
Ctla4tm1Shr/Ctla4tm1Shr
involves: 129S4/SvJae * BALB/c 		abnormal cytokine secretion J:57090
abnormal T cell physiology J:57090
increased T cell proliferation J:57090
Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcrAND)53Hed/0
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal T cell activation J:119845
increased interleukin-4 secretion J:119845
increased T cell proliferation J:119845
Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)8Rest/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:140448
normal mortality/aging J:140448
normal pigmentation phenotype J:140448
Ctla4tm1All/Ctla4tm1All
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL 		abnormal splenocyte physiology J:109887
enlarged spleen J:109887
increased acute inflammation J:109887
insulitis J:109887
normal mortality/aging J:109887
Ctla4tm1All/Ctla4tm1All
Tg(TcrAND)53Hed/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal lymphopoiesis J:119845
abnormal T cell activation J:119845
abnormal T cell subpopulation ratio J:119845
increased CD4-positive, alpha-beta T cell number J:119845
increased CD8-positive, alpha-beta T cell number J:119845
premature death J:119845
Ctla4tm1All/Ctla4tm1All
Tg(TcraTcrb)8Rest/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased CD8-positive, alpha-beta T cell number J:140448
increased CD4-positive, alpha-beta T cell number J:140448
increased interferon-gamma secretion J:140448
premature death J:140448
variable depigmentation J:140448
Ctla4tm1Shr/Ctla4tm1Shr
Rag2tm1Fwa/Rag2tm1Fwa
Tg(DO11.10)10Dlo/0
involves: 129S/Sv * BALB/c * C3H * C57BL/6 		abnormal cytokine secretion J:110446
abnormal T cell physiology J:110446
normal immune system phenotype J:110446
Ctla4tm1Shr/Ctla4tm1Shr
Tg(DO11.10)10Dlo/0
involves: 129S4/SvJae * BALB/c * C3H * C57BL/6 		abnormal T cell physiology J:57090
enlarged lymph nodes J:57090
enlarged spleen J:57090
increased T cell proliferation J:57090
Tg(Cd152Ig)1Jbs/0
involves: C3H * NOD 		increased susceptibility to autoimmune diabetes J:35353
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory