About   Help   FAQ
Cryaa Gene Detail
Summary
  • Symbol
    Cryaa
  • Name
    crystallin, alpha A
  • Synonyms
    Acry-1, alpha-A-crystallin, Crya1, Crya-1, DAcry-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88515
    NCBI Gene: 12954
  • Gene Overview
    MyGene.info: CRYAA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:31677933-31681724 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3792 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.09 cM, cytoband A3-B
  • Mapping Data
    48 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    CRYAA, crystallin alpha A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRYAA, crystallin alpha A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRYA1, CTRCT9, HSPB4
  • Links
    NCBI Gene ID: 1409
    neXtProt AC: NX_P02489
    UniProt: P02489

  • Chr Location
    21q22.3; chr21:43169008-43172810 (+)  GRCh38.p7

  • Human Ortholog
    CRYAA2, crystallin alpha A2
    Orthology source: HomoloGene
  • Synonyms
    CRYAA
  • Links
    NCBI Gene ID: 102724652
    neXtProt AC: NX_P02489
    UniProt: A0A140G945

  • Chr Location
    chr21:6560724-6564489 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cryaa mouse models; 1 with human CRYAA associations

Human Disease Mouse Models
      
IDs
View 9 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 8 alleles in 10 genetic backgrounds
    12 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation have small lenses that develop progressive opacity beginning in the nucleus. Homozygotes for spontaneous or ENU-induced mutations have normal sized lenses with a white nuclear cataract by weaning age that expands progressively.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024041 Ensembl Gene Model | MGI Sequence Detail 3792 C57BL/6J ±  kb
    transcript ENSMUST00000019192 Ensembl | MGI Sequence Detail 1176 Not Applicable  
    polypeptide ENSMUSP00000019192 Ensembl | MGI Sequence Detail 196 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      133 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 181
      Genomic 7
      cDNA 162
      Primer pair 6
      Other 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1071, MGD-MRK-2160, MGD-MRK-2162, MGD-MRK-36289, MGD-MRK-8792, MGI:107713, MGI:2146823
    References
    more
    • Summaries
      All 201
      Developmental Gene Expression 69
      Diseases 7
      Gene Ontology 17
      Phenotypes 43
    • Earliest
      J:6970 King CR, et al., alpha A-crystallin messenger RNA of the mouse lens: more noncoding than coding sequences. Science. 1982 Feb 19;215(4535):985-7
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory