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Cryaa
Gene Detail
Symbol

Name
ID
Cryaa
crystallin, alpha A
MGI:88515
Synonyms
Acry-1, alpha-A-crystallin, Crya1, Crya-1, DAcry-1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.09 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(48)
Sequence Map
Chr17:31677933-31681722 bp, + strand
From Ensembl annotation of GRCm38

  3790 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48053  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRYAA, LOC102724652
Protein SuperFamily: alpha-crystallin
Gene Tree: Cryaa

Human
homologs
CRYAA, crystallin, alpha A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1409
neXtProt AC: NX_P02489

Human Synonyms: CRYA1, CTRCT9, HSPB4

Human Chr (Location): 21q22.3; chr21:43169008-43172810 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CRYAA

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(2) Spontaneous(2) Targeted(9)
Genomic Mutations involving Cryaa (2)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation have small lenses that develop progressive opacity beginning in the nucleus. Homozygotes for spontaneous or ENU-induced mutations have normal sized lenses with a white nuclear cataract by weaning age that expands progressively.
 
Human Diseases Modeled in Mice Using Cryaa (1)    Mutations Annotated to Human Diseases (6)    Phenotype Images(12)
Interactions
Cryaa interacts with 63 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process actin filament organization, apoptotic process, ...
Component cytoplasm, extracellular exosome, ...
Function identical protein binding, metal ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (66 records)
Data Summary: Results (244)    Tissues (145)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 194
RT-PCR 38
cDNA source data(159)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN cryaa    NEW 
Molecular
reagents
All nucleic(176) Genomic(7) cDNA(161) Primer pair(5) Other(3)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000024041 (Evidence)
Entrez Gene 12954 (Evidence)
UniGene 1228
DFCI TC1572520, TC1583666
DoTS DT.101277277, DT.103568730, DT.99848968
NIA Mouse Gene Index U017804
Consensus CDS Project CCDS37551.1
International Mouse Phenotyping Consortium Status Cryaa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024041 Ensembl Gene Model | MGI Sequence Detail 3790 C57BL/6J ±  kb
transcript ENSMUST00000019192 Ensembl | MGI Sequence Detail 1186 Not Applicable 
polypeptide ENSMUSP00000019192 Ensembl | MGI Sequence Detail 196 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(17) : SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001436 Alpha crystallin/Heat shock protein
InterPro IPR002068 Alpha crystallin/Hsp20 domain
InterPro IPR003090 Alpha-crystallin, N-terminal
InterPro IPR012274 Alpha-crystallin, subunit A
InterPro IPR008978 HSP20-like chaperone
InterPro IPR031107 Small heat shock protein HSP20
Protein Ontology PR:000005907 alpha-crystallin A chain
References
(Earliest) J:19720 King CR, et al., Alternative RNA splicing of the murine alpha A-crystallin gene: protein-coding information within an intron. Cell. 1983 Mar;32(3):707-12
(Latest) J:215164 Andley UP, et al., In vivo substrates of the lens molecular chaperones alphaA-crystallin and alphaB-crystallin. PLoS One. 2014;9(4):e95507
All references(175)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-1071, MGD-MRK-2160, MGD-MRK-2162, MGD-MRK-36289, MGD-MRK-8792, MGI:107713, MGI:2146823

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory