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Cryaa Gene Detail
Summary
  • Symbol
    Cryaa
  • Name
    crystallin, alpha A
  • Synonyms
    Acry-1, alpha-A-crystallin, Crya-1, Crya1, DAcry-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88515
    NCBI Gene: 12954
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:31896905-31900704 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.09 cM, cytoband A3-B
  • Mapping Data
    48 experiments
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88515
 protein coding gene Chr17:31896781-31900707 (+)
129S1/SvImJ ENSMUSG00200050255
 protein coding gene Chr17:27583158-27587090 (+)
A/J ENSMUSG00195052690
 protein coding gene Chr17:28516363-28520281 (+)
AKR/J ENSMUSG00220053350
 protein coding gene Chr17:27544381-27548299 (+)
BALB/cJ ENSMUSG00180047393
 protein coding gene Chr17:27858727-27862659 (+)
C3H/HeJ ENSMUSG00175052869
 protein coding gene Chr17:27425536-27429454 (+)
C57BL/6NJ ENSMUSG00215053567
 protein coding gene Chr17:27414762-27418689 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021373
 protein coding gene Chr17:27556354-27560151 (+)
CAST/EiJ ENSTCUG00005039858
 protein coding gene Chr17:28419133-28423052 (+)
CBA/J ENSMUSG00210043707
 protein coding gene Chr17:27252462-27256380 (+)
DBA/2J ENSMUSG00185046516
 protein coding gene Chr17:29869167-29873099 (+)
FVB/NJ ENSMUSG00205039855
 protein coding gene Chr17:27724716-27728642 (+)
JF1/MsJ ENSUMUG00000056216
 protein coding gene Chr17:29160425-29164329 (+)
LP/J ENSMUSG00230054355
 protein coding gene Chr17:30978262-30985622 (+)
NOD/ShiLtJ ENSMUSG00190048818
 protein coding gene Chr17:27374845-27378776 (+)
NZO/HlLtJ ENSMUSG00225053159
 protein coding gene Chr17:33015245-33022604 (+)
PWK/PhJ ENSLUMG00010053257
 protein coding gene Chr17:26984527-26988432 (+)
SPRET/EiJ ENSMSPG00010036819
 protein coding gene Chr17:28111218-28115121 (+)
WSB/EiJ ENSIUOG00005049370
 protein coding gene Chr17:28131763-28135687 (+)



Homology
more
  • Human Ortholog
    CRYAA, crystallin alpha A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYAA, crystallin alpha A
  • Synonyms
    CRYA1, CTRCT9, HSPB4
  • Links
    NCBI Gene ID: 1409
    UniProt: P02489

  • Chr Location
    21q22.3; chr21:43169008-43172810 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cryaa mouse models; 1 with human CRYAA associations

Human Disease Mouse Models
      
IDs
 View 9 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 8 alleles in 10 genetic backgrounds
    12 images
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation have small lenses that develop progressive opacity beginning in the nucleus. Homozygotes for spontaneous or ENU-induced mutations have normal sized lenses with a white nuclear cataract by weaning age that expands progressively.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    917
  • Tissues
    160
  • cDNA Data
    161
  • Literature Summary
    81
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12954 NCBI Gene Model | MGI Sequence Detail 3800 C57BL/6J ±  kb
    transcript NM_001278569 RefSeq | MGI Sequence Detail 1214 ZRU/MplStud  
    polypeptide P24622 UniProt | EBI | MGI Sequence Detail 196 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 184
      Genomic 7
      cDNA 163
      Primer pair 6
      Other 8
      Antibodies 12

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1071, MGD-MRK-2160, MGD-MRK-2162, MGD-MRK-36289, MGD-MRK-8792, MGI:107713, MGI:2146823
    References
    more
    • Summaries
      All 246
      Developmental Gene Expression 81
      Diseases 7
      Gene Ontology 23
      Phenotypes 66
    • Earliest
      J:6970 King CR, et al., alpha A-crystallin messenger RNA of the mouse lens: more noncoding than coding sequences. Science. 1982 Feb 19;215(4535):985-7
    • Latest
      J:384798 Rayee D, et al., RNA-binding proteins in the mouse lens: Functional classifications, expression profiling, and interaction studies of Carhsp1 with crystallin mRNAs. Dev Biol. 2026 Apr 28;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory