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Cryaa Gene Detail
Summary
  • Symbol
    Cryaa
  • Name
    crystallin, alpha A
  • Synonyms
    Acry-1, alpha-A-crystallin, Crya1, Crya-1, DAcry-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88515
    NCBI Gene: 12954
Location & Maps
more
  • Sequence Map
    Chr17:31677933-31681722 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3790 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.09 cM, cytoband A3-B
  • Mapping Data
    48 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    CRYAA, crystallin alpha A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRYAA, crystallin alpha A
    Orthology source: HomoloGene
  • Synonyms
    CRYA1, CTRCT9, HSPB4
  • Links
    NCBI Gene ID: 1409
    neXtProt AC: NX_P02489

  • Chr Location
    21q22.3; chr21:43169008-43172810 (+)  GRCh38.p2

  • Human Ortholog
    LOC102724652, alpha-crystallin A chain
    Orthology source: HomoloGene
  • Synonyms
    CRYAA
  • Links
    NCBI Gene ID: 102724652

  • Chr Location
    chr21:6560656-6564489 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cryaa mouse models; 1 with human CRYAA associations

Human Disease Mouse Models
       Cataract 9, Multiple Types; CTRCT9   OMIM: 604219 View 9 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 8 alleles in 10 genetic backgrounds
    12 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    2
  • Spontaneous
    2
  • Targeted
    9
  • Genomic Mutations
    2 involving Cryaa
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation have small lenses that develop progressive opacity beginning in the nucleus. Homozygotes for spontaneous or ENU-induced mutations have normal sized lenses with a white nuclear cataract by weaning age that expands progressively.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024041 Ensembl Gene Model | MGI Sequence Detail 3790 C57BL/6J ±  kb
transcript ENSMUST00000019192 Ensembl | MGI Sequence Detail 1186 Not Applicable  
polypeptide ENSMUSP00000019192 Ensembl | MGI Sequence Detail 196 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    133 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 176
    Genomic 7
    cDNA 161
    Primer pair 5
    Other 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1071, MGD-MRK-2160, MGD-MRK-2162, MGD-MRK-36289, MGD-MRK-8792, MGI:107713, MGI:2146823
References
more
  • Summaries
    All 176
    Developmental Gene Expression 67
    Diseases 7
    Gene Ontology 17
    Phenotypes 36
  • Earliest
    J:19720 King CR, et al., Alternative RNA splicing of the murine alpha A-crystallin gene: protein-coding information within an intron. Cell. 1983 Mar;32(3):707-12
  • Latest
    J:230984 Xu Q, et al., Knockout of alphaA-crystallin inhibits ocular neovascularization. Invest Ophthalmol Vis Sci. 2015 Feb;56(2):816-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory