Cryaa
Gene Detail

Symbol Name ID

Cryaa crystallin, alpha A MGI:88515

STS

D17Mit16, D17Mit62, D17Mit63, D17Mit82, D17Rua3

Synonyms

Acry-1, alpha-A-crystallin, Crya1, Crya-1, DAcry-1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

17.09 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(48)

Sequence Map

Chr17:31677945-31681724 bp, + strand From NCBI annotation of GRCm38   3780 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48053  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: alpha-crystallin
Gene Tree: Cryaa

Human homologs

Human Homolog		CRYAA, crystallin, alpha A
NCBI Gene ID		1409
neXtProt AC		NX_P02489
Human Synonyms		CRYA1, CTRCT9, HSPB4
Human Chr (Location)		21q22.3; chr21:44589141-44592913 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CRYAA

Alleles and phenotypes

All alleles(11) : Targeted(7) Spontaneous(2) Chemically induced(2)
 

Homozygotes for a targeted null mutation have small lenses that develop progressive opacity beginning in the nucleus. Homozygotes for spontaneous or ENU-induced mutations have normal sized lenses with a white nuclear cataract by weaning age that expands progressively.

 
Human Diseases Modeled Using Mouse Cryaa (2)    Alleles Annotated to Human Diseases(5)    Phenotype Images(12)

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	actin filament organization, apoptotic process, ...
Component	cytoplasm, nucleus
Function	metal ion binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (62 records)
Data Summary: Results (240)    Tissues (141)    Images (20)
Theiler Stages: 13, 15, 16, 17, 18, 19, 20, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	192
RT-PCR	38

cDNA source data(159)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(174) Genomic(7) cDNA(160) Primer pair(4) Other(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000024041 (Evidence)
Entrez Gene	12954 (Evidence)
UniGene	1228
DFCI	TC1572520, TC1583666
DoTS	DT.101277277, DT.103568730, DT.99848968
NIA Mouse Gene Index	U017804
Consensus CDS Project	CCDS37551.1
International Mouse Knockout Project Status	Cryaa

Sequences

Length	Strain/Species
genomic	12954	NCBI Gene Model | MGI Sequence Detail	3780	C57BL/6J
transcript	NM_013501	RefSeq | MGI Sequence Detail	1192	C57BL/6
polypeptide	P24622	UniProt | EBI | MGI Sequence Detail	196	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(17) : SNPs(50 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001436	Alpha crystallin/Heat shock protein
InterPro	IPR002068	Alpha crystallin/Hsp20 domain
InterPro	IPR003090	Alpha-crystallin, N-terminal
InterPro	IPR012274	Alpha-crystallin, subunit A
InterPro	IPR008978	HSP20-like chaperone
Protein Ontology	PR:000005907	alpha-crystallin A chain

Graphical View of Protein Domain Structure

References

(Earliest) J:19720 King CR, et al., Alternative RNA splicing of the murine alpha A-crystallin gene: protein-coding information within an intron. Cell. 1983 Mar;32(3):707-12
(Latest) J:189250 Widau RC, et al., p19Arf Represses Platelet-Derived Growth Factor Receptor beta by Transcriptional and Posttranscriptional Mechanisms. Mol Cell Biol. 2012 Nov;32(21):4270-82
All references(174)

Other accession IDs

MGD-MRK-1071, MGD-MRK-2160, MGD-MRK-2162, MGD-MRK-36289, MGD-MRK-8792, MGI:107713, MGI:2146823