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Gene Detail
crystallin, alpha A
STS D17Mit16, D17Mit62, D17Mit63, D17Mit82, D17Rua3
Synonyms Acry-1, alpha-A-crystallin, Crya1, Crya-1, DAcry-1
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.09 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM

Mapping data(48)
Sequence Map
Chr17:31677945-31681724 bp, + strand
From NCBI annotation of GRCm38

  3780 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:48053  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: alpha-crystallin
Gene Tree: Cryaa

Human Homolog CRYAA, crystallin, alpha A
NCBI Gene ID 1409
neXtProt AC  NX_P02489
Human Synonyms  CRYA1, CTRCT9, HSPB4
Human Chr (Location)  21q22.3; chr21:43169031-43172805 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CRYAA
Human Homolog LOC102724652, alpha-crystallin A chain-like
NCBI Gene ID 102724652
neXtProt AC  NX_P02489
Human Chr (Location)  chr21:6560696-6564489 (+)  GRCh38
alleles, and
All mutations/alleles(13) : Chemically induced (ENU)(2) Spontaneous(2) Targeted(9)
Genomic Mutations involving Cryaa (2)
Incidental mutations (data from APF )
Homozygotes for a targeted null mutation have small lenses that develop progressive opacity beginning in the nucleus. Homozygotes for spontaneous or ENU-induced mutations have normal sized lenses with a white nuclear cataract by weaning age that expands progressively.
Human Diseases Modeled Using Mouse Cryaa (1)    Alleles Annotated to Human Diseases(6)    Phenotype Images(12)
Cryaa interacts with 64 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (39 annotations)
Process actin filament organization, apoptotic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function identical protein binding, metal ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (65 records)
Data Summary: Results (244)    Tissues (145)    Images (22)
Theiler Stages: 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 194
cDNA source data(159)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(176) Genomic(7) cDNA(161) Primer pair(5) Other(3)
Microarray probesets(5)
Other database
Ensembl Gene ModelENSMUSG00000024041 (Evidence)
Entrez Gene12954 (Evidence)
DFCITC1572520, TC1583666
DoTSDT.101277277, DT.103568730, DT.99848968
NIA Mouse Gene IndexU017804
Consensus CDS ProjectCCDS37551.1
International Mouse Knockout Project StatusCryaa
Representative SequencesLengthStrain/SpeciesFlank
genomic 12954 NCBI Gene Model | MGI Sequence Detail 3780 C57BL/6J ±  kb
transcript NM_001278569 RefSeq | MGI Sequence Detail 1214 C57BL/6 
polypeptide P24622 UniProt | EBI | MGI Sequence Detail 196 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(8) UniProt(3)
Polymorphisms RFLP(17) : SNPs within 2kb(89 from dbSNP Build 137)
InterPro IPR001436 Alpha crystallin/Heat shock protein
InterPro IPR002068 Alpha crystallin/Hsp20 domain
InterPro IPR003090 Alpha-crystallin, N-terminal
InterPro IPR012274 Alpha-crystallin, subunit A
InterPro IPR008978 HSP20-like chaperone
Protein Ontology PR:000005907 alpha-crystallin A chain
Graphical View of Protein Domain Structure
References (Earliest) J:19720 King CR, et al., Alternative RNA splicing of the murine alpha A-crystallin gene: protein-coding information within an intron. Cell. 1983 Mar;32(3):707-12
(Latest) J:201930 Andley UP, et al., Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins alphaA- and alphaB-crystallin. Biochemistry. 2013 Apr 30;52(17):2933-48
All references(181)
Disease annotation references (5)
accession IDs
MGD-MRK-1071, MGD-MRK-2160, MGD-MRK-2162, MGD-MRK-36289, MGD-MRK-8792, MGI:107713, MGI:2146823

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory