Phenotypes for Cryaa MGI:3784582 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cryaa^tm1.1Ady/Cryaa⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cryaa^tm1.1Ady mutation (0 available); any Cryaa mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Lens opacity in Cryaa^tm1.1Ady/Cryaa⁺, and Cryaa^tm1.1Ady/Cryaa^tm1.1Ady mice and microphthalmia in Cryaa^tm1.1Ady/Cryaa^tm1.1Ady mice

vision/eye

abnormal lens morphology ( J:132296 )

• increased amounts of alphaA-crystallin and alphaB-crystallin in the lens-insoluble fractions at lesser degree than homozygous mice

cataract ( J:132296 )

• less severe lens opacities in heterozygous mice compared to homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 9 multiple types		DOID:0110266	OMIM:604219	J:132296

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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