Cryaa^lop18
Spontaneous Allele Detail

Summary

• Symbol: Cryaa^lop18
• Name: crystallin, alpha A; lens opacity 18
• MGI ID: MGI:1858023
• Synonyms: alphaA-His
• Gene: Cryaa Location: Chr17:31896905-31900704 bp, + strand Genetic Position: Chr17, 17.09 cM, cytoband A3-B
• Alliance: Cryaa^lop18 page

Mutation origin

• Strain of Origin: CBA/CaGnLeJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A G-to-A transition at coding nucleotide 161 of the mRNA that converts codon 54 from an arginine to a histidine (p.R54H). (J:59482)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cryaa Mutation: 14 strains or lines available

References

• Original: J:34933 Chang B, et al., Chromosomal localization of a new mouse lens opacity gene (lop18). (Correction: vol. 39(2):237). Genomics. 1996 Aug 15;36(1):171-3
• All: 3 reference(s)