Phenotypes Associated with This Genotype

Genotype
MGI:2175800

• Allelic Composition: Cryaa^tm1Wawr/Cryaa^tm1Wawr
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lens opacity in Cryaa^tm1Wawr/Cryaa^tm1Wawr mice

vision/eye

increased lens epithelium apoptosis ( J:82601 )

• death of lens epithelial cells was noted in TUNEL and BrdU experiments; cause appeared to be due to defects in mitosis

cataract ( J:38210 )

• mild cataract at 7 weeks of age; progressive severity to dense opacity by 10 weeks of age

small lens ( J:38210 )

• small lens; 25-35% reduced weight and 15% reduced axial and equatorial dimensions

• inclusion bodies composed of crystallin proteins observed in nuclear and inner cortical regions

microphthalmia ( J:38210 )

• small eyes

cellular

increased lens epithelium apoptosis ( J:82601 )

• death of lens epithelial cells was noted in TUNEL and BrdU experiments; cause appeared to be due to defects in mitosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 9 multiple types		DOID:0110266	OMIM:604219	J:38210