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Ccnd2
Gene Detail
 Symbol
Name
ID
Ccnd2
cyclin D2
MGI:88314
Synonyms 2600016F06Rik, cD2, Vin1, Vin-1
Feature Type protein coding gene
Genetic Map
Chromosome 6
61.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr6:127125779-127151048 bp, - strand
From Ensembl annotation of GRCm38

  25270 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37525  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cyclin, A/B/D/E types
Gene Tree: Ccnd2

Human
homologs
Human Homolog CCND2, cyclin D2
NCBI Gene ID 894
neXtProt AC  NX_P30279
Human Synonyms  KIAK0002, MPPH3
Human Chr (Location)  12p13; chr12:4273736-4305356 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CCND2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are sterile: females lack a granulosa cell response to follicle stimulating hormone, while males have hypoplastic testes. Mutants also show decreased cerebellar granule cell and stellate neuron populations.
 
Interactions
Ccnd2 interacts with 366 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell cycle, cell division, ...
Component chromatin, cyclin-dependent protein kinase holoenzyme complex, ...
Function protein binding, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (159 records)
Data Summary: Results (517)    Tissues (359)    Images (93)
Theiler Stages: 2, 3, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 360
Northern blot 39
Western blot 12
RT-PCR 96
cDNA source data(418)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(454) Genomic(19) cDNA(421) Primer pair(8) Other(6)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000000184 (Evidence)
Entrez Gene12444 (Evidence)
UniGene333406
DFCITC1573588, TC1586663, TC1591726, TC1615415, TC1623806, TC1659871
DoTSDT.101405514, DT.101405519, DT.103576672, DT.110479076, DT.495919, DT.535688, DT.94349409, DT.97343648
NIA Mouse Gene IndexU043852, U201255
Consensus CDS ProjectCCDS20564.1
International Mouse Knockout Project StatusCcnd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000184 Ensembl Gene Model | MGI Sequence Detail 25270 C57BL/6J ±  kb
transcript ENSMUST00000000188 Ensembl | MGI Sequence Detail 5701 Not Applicable 
polypeptide ENSMUSP00000000188 Ensembl | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(154 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014400 Cyclin A/B/D/E
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR015451 Cyclin D
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
Protein Ontology PR:000005122 G1/S-specific cyclin-D2
References (Earliest) J:14776 Matsushime H, et al., Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell. 1991 May 17;65(4):701-13
(Latest) J:211057 Gilani AI, et al., Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7450-5
All references(252)
Other
accession IDs
MGD-MRK-15396, MGD-MRK-15397, MGD-MRK-1826, MGI:1353647, MGI:1913821, MGI:2141781, MGI:2683668

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory