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Ccnd2
Gene Detail
Symbol

Name
ID
Ccnd2
cyclin D2
MGI:88314
Synonyms
2600016F06Rik, cD2, Vin1, Vin-1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
61.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr6:127125162-127152193 bp, - strand
From VEGA annotation of GRCm38

  27032 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37525  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CCND2
Protein SuperFamily: cyclin, A/B/D/E types
Gene Tree: Ccnd2

Human
homologs
CCND2, cyclin D2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 894
neXtProt AC: NX_P30279

Human Synonyms: KIAK0002, MPPH3

Human Chr (Location): 12p13; chr12:4273733-4305356 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CCND2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are sterile: females lack a granulosa cell response to follicle stimulating hormone, while males have hypoplastic testes. Mutants also show decreased cerebellar granule cell and stellate neuron populations.
 
Interactions
Ccnd2 interacts with 365 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell cycle, cell division, ...
Component chromatin, cyclin-dependent protein kinase holoenzyme complex, ...
Function protein binding, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (168 records)
Data Summary: Results (517)    Tissues (359)    Images (93)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 360
Northern blot 39
Western blot 12
RT-PCR 96
cDNA source data(418)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA CCND2 ; Xenbase ccnd2    NEW 
Molecular
reagents
All nucleic(454) Genomic(19) cDNA(421) Primer pair(8) Other(6)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000056347 (Evidence)
Ensembl Gene Model ENSMUSG00000000184 (Evidence)
Entrez Gene 12444 (Evidence)
UniGene 333406
DFCI TC1573588, TC1586663, TC1591726, TC1615415, TC1623806, TC1659871
DoTS DT.101405514, DT.101405519, DT.103576672, DT.110479076, DT.495919, DT.535688, DT.94349409, DT.97343648
NIA Mouse Gene Index U043852, U201255
Consensus CDS Project CCDS20564.1
International Mouse Phenotyping Consortium Status Ccnd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056347 VEGA Gene Model | MGI Sequence Detail 27032 C57BL/6J ±  kb
transcript OTTMUST00000139250 VEGA | MGI Sequence Detail 6330 Not Applicable 
polypeptide OTTMUSP00000073089 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(162 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR015451 Cyclin D
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
Protein Ontology PR:000005122 G1/S-specific cyclin-D2
References
(Earliest) J:14776 Matsushime H, et al., Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell. 1991 May 17;65(4):701-13
(Latest) J:221638 Parmigiani E, et al., Heterogeneity and Bipotency of Astroglial-Like Cerebellar Progenitors along the Interneuron and Glial Lineages. J Neurosci. 2015 May 13;35(19):7388-402
All references(263)
Other
accession IDs
MGD-MRK-15396, MGD-MRK-15397, MGD-MRK-1826, MGI:1353647, MGI:1913821, MGI:2141781, MGI:2683668

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory