Analysis Tools
neoplasm
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• 5 of 17 mice in an aging cohort developed lymphomas
• tumors were composed of monomorphic, small-sized cells with irregular hyperchromatic nuclei, displayed an MCL-like CD19+ CD20+ CD5+ CD23- immunophenotype, and express mantle cell lymphoma (MCL) marker Sox11
• mice with lymphomas have nodules or infiltrates of proliferating B220+ KI67+ neoplastic B cells in their gastrointestinal tract, liver, spleen, and mediastinal lymph nodes
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growth/size/body
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• in 3 mice severe splenomegaly with profound loss of normal parenchymal architecture is seen
• the white pulp compartment is obscured by dense proliferation of small to medium-sized lymphoid cells
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hematopoietic system
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• in 3 mice severe splenomegaly with profound loss of normal parenchymal architecture is seen
• the white pulp compartment is obscured by dense proliferation of small to medium-sized lymphoid cells
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immune system
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• in 3 mice severe splenomegaly with profound loss of normal parenchymal architecture is seen
• the white pulp compartment is obscured by dense proliferation of small to medium-sized lymphoid cells
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| mantle cell lymphoma | DOID:0050746 | J:323008 | ||
