Gt(ROSA)26Sor^{tm1(Ccnd2)Goos}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Ccnd2)Goos}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Steven Goossens
• MGI ID: MGI:8290645
• Synonyms: R26-Ccnd2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Ccnd2)Goos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:323008
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Ccnd2)Goos} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ccnd2 (MGI:88314)

• Mutation details: Recombinase-mediated cassette exchange inserted a construct containing a floxed-STOP cassette, open reading frame of mouse Ccnd2 (BC049086), IRES, GFP/luc cassette, and pgk ATG into the locus. (J:323008)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:323008 Pieters T, et al., Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice. J Exp Med. 2021 Oct 4;218(10):e20202280
• All: 1 reference(s)