Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(Ccnd2)Goos}
• Allele Name: targeted mutation 1, Steven Goossens
• Allele ID: MGI:8290645
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd79a^tm1(cre)Reth/Cd79a^+ Gt(ROSA)26Sor^tm1(Ccnd2)Goos/Gt(ROSA)26Sor^tm1(Ccnd2)Goos Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/c * C57BL/6NCrl	MGI:8290654
cn2	Commd10^Tg(Vav1-icre)A2Kio/Commd10^+ Gt(ROSA)26Sor^tm1(Ccnd2)Goos/Gt(ROSA)26Sor^tm1(Ccnd2)Goos	involves: 129S6/SvEvTac * C57BL/6NCrl * C57BL/10 * CBA/Ca	MGI:8290647

Genotype
MGI:8290654

cn1

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Gt(ROSA)26Sor^{tm1(Ccnd2)Goos}/Gt(ROSA)26Sor^{tm1(Ccnd2)Goos}; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/c * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:323008 )

• median survival of 269 d

neoplasm

abnormal tumor morphology ( J:323008 )

• more frequent infiltration of proliferating tumor cells in the small intestine compared to mutant mice not over-expressing Ccnd2

• in 9 of 17 mice lymphomas have a mantle cell lymphoma (MCL) like immunophenotype unlike mutant mice that do not over-express Ccnd2

• about half of mice show only MCL-like lymphomas while others carry a mix of MCL and non-MCL lymphomas

• tumor cells have B1-specific B-cell receptors and elevated B cell receptor signalling

increased lymphoma incidence ( J:323008 )

• develop lymphadenopathies significantly sooner compared to mutant mice that do not over-express Ccnd2

• lymphomas are frequently seen in peripheral lymphoid tissue including mandibular, axillary, inguinal, and mediastinal lymph nodes, and distributed throughout the body with infiltrations in the spleen, liver, peripheral blood, and small intestine

• lymphomas are IgM+IgD+

• these are aggressive and transplantable MCL-like tumors

immune system

immune system phenotype ( J:323008 )

N • no major abnormalities are seen in B2 cell development or in the expansion of B1a cells in tumor free mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
mantle cell lymphoma		DOID:0050746		J:323008

Genotype
MGI:8290647

cn2

• Allelic Composition: Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺; Gt(ROSA)26Sor^{tm1(Ccnd2)Goos}/Gt(ROSA)26Sor^{tm1(Ccnd2)Goos}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * C57BL/10 * CBA/Ca

neoplasm

increased lymphoma incidence ( J:323008 )

• 5 of 17 mice in an aging cohort developed lymphomas

• tumors were composed of monomorphic, small-sized cells with irregular hyperchromatic nuclei, displayed an MCL-like CD19+ CD20+ CD5+ CD23- immunophenotype, and express mantle cell lymphoma (MCL) marker Sox11

• mice with lymphomas have nodules or infiltrates of proliferating B220+ KI67+ neoplastic B cells in their gastrointestinal tract, liver, spleen, and mediastinal lymph nodes

growth/size/body

enlarged spleen ( J:323008 )

• in 3 mice severe splenomegaly with profound loss of normal parenchymal architecture is seen

• the white pulp compartment is obscured by dense proliferation of small to medium-sized lymphoid cells

hematopoietic system

enlarged spleen ( J:323008 )

• in 3 mice severe splenomegaly with profound loss of normal parenchymal architecture is seen

• the white pulp compartment is obscured by dense proliferation of small to medium-sized lymphoid cells

immune system

enlarged spleen ( J:323008 )

• in 3 mice severe splenomegaly with profound loss of normal parenchymal architecture is seen

• the white pulp compartment is obscured by dense proliferation of small to medium-sized lymphoid cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
mantle cell lymphoma		DOID:0050746		J:323008