Phenotypes Associated with This Genotype

Genotype
MGI:8290654

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Gt(ROSA)26Sor^{tm1(Ccnd2)Goos}/Gt(ROSA)26Sor^{tm1(Ccnd2)Goos}; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/c * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:323008 )

• median survival of 269 d

neoplasm

abnormal tumor morphology ( J:323008 )

• more frequent infiltration of proliferating tumor cells in the small intestine compared to mutant mice not over-expressing Ccnd2

• in 9 of 17 mice lymphomas have a mantle cell lymphoma (MCL) like immunophenotype unlike mutant mice that do not over-express Ccnd2

• about half of mice show only MCL-like lymphomas while others carry a mix of MCL and non-MCL lymphomas

• tumor cells have B1-specific B-cell receptors and elevated B cell receptor signalling

increased lymphoma incidence ( J:323008 )

• develop lymphadenopathies significantly sooner compared to mutant mice that do not over-express Ccnd2

• lymphomas are frequently seen in peripheral lymphoid tissue including mandibular, axillary, inguinal, and mediastinal lymph nodes, and distributed throughout the body with infiltrations in the spleen, liver, peripheral blood, and small intestine

• lymphomas are IgM+IgD+

• these are aggressive and transplantable MCL-like tumors

immune system

immune system phenotype ( J:323008 )

N • no major abnormalities are seen in B2 cell development or in the expansion of B1a cells in tumor free mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
mantle cell lymphoma		DOID:0050746		J:323008