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Camk2b Gene Detail
Summary
  • Symbol
    Camk2b
  • Name
    calcium/calmodulin-dependent protein kinase II, beta
  • Synonyms
    CaMK II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88257
    NCBI Gene: 12323
  • Gene Overview
    MyGene.info: CAMK2B
Location & Maps
more
  • Sequence Map
    Chr11:5969644-6066362 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      96719 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.89 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    CAMK2B, calcium/calmodulin dependent protein kinase II beta
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CAMK2B, calcium/calmodulin dependent protein kinase II beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAM2, CAMK2, CAMKB
  • Links
    NCBI Gene ID: 816
    neXtProt AC: NX_Q13554

  • Chr Location
    7p14.3-p14.1; chr7:44217150-44325994 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Gene trapped
    17
  • Targeted
    7
  • Incidental Mutations
    APF
Mice homozygous for a null allele exhibit reversal of plasticity direction at parallel fiber-Purkinje cell synapses. Mice homozygous for a different null allele show motor impairments, including ataxia, altered body mass composition, a reduction in anxiety-related behavior, and cognitive deficits.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005105 VEGA Gene Model | MGI Sequence Detail 96719 C57BL/6J ±  kb
transcript OTTMUST00000011425 VEGA | MGI Sequence Detail 2223 Not Applicable  
polypeptide OTTMUSP00000005324 VEGA | MGI Sequence Detail 666 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    408 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000003200 calcium/calmodulin-dependent protein kinase type II subunit beta
  • EC
  • InterPro Domains
    IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
    IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
    IPR032710 NTF2-like domain
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 57
    Genomic 2
    cDNA 53
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1744
References
more
  • Summaries
    All 66
    Developmental Gene Expression 11
    Gene Ontology 13
    Phenotypes 10
  • Earliest
    J:1487 Karls U, et al., Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant. Mol Cell Biol. 1992 Aug;12(8):3644-52
  • Latest
    J:219040 Bachstetter AD, et al., Generation and behavior characterization of CaMKIIbeta knockout mice. PLoS One. 2014;9(8):e105191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory