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Camk2b
Gene Detail
Symbol

Name
ID
Camk2b
calcium/calmodulin-dependent protein kinase II, beta
MGI:88257
Synonyms
CaMK II
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr11:5969644-6066362 bp, - strand
From VEGA annotation of GRCm38

  96719 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:111050  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CAMK2B
Protein SuperFamily: calcium/calmodulin-dependent protein kinase II
Gene Tree: Camk2b

Human
homologs
CAMK2B, calcium/calmodulin-dependent protein kinase II beta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 816
neXtProt AC: NX_Q13554

Human Synonyms: CAM2, CAMK2, CAMKB

Human Chr (Location): 7p14.3-p14.1; chr7:44217150-44325994 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(17) Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit reversal of plasticity direction at parallel fiber-Purkinje cell synapses.
 
Interactions
Camk2b interacts with 236 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process activation of meiosis involved in egg activation, calcium ion transport, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (314)    Tissues (101)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 268
RT-PCR 46
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase camk2b    NEW 
Molecular
reagents
All nucleic(57) Genomic(2) cDNA(53) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005105 (Evidence)
Ensembl Gene Model ENSMUSG00000057897 (Evidence)
Entrez Gene 12323 (Evidence)
UniGene 439733
DFCI TC1576025, TC1587035, TC1593226, TC1598554, TC1617955, TC1689622
DoTS DT.101148087, DT.101264232, DT.110526260, DT.40169561, DT.94238857, DT.97407095
NIA Mouse Gene Index U032479
EC 2.7.11.17
Consensus CDS Project CCDS24411.1, CCDS48748.1, CCDS48749.1
International Mouse Phenotyping Consortium Status Camk2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005105 VEGA Gene Model | MGI Sequence Detail 96719 C57BL/6J ±  kb
transcript OTTMUST00000011425 VEGA | MGI Sequence Detail 2223 Not Applicable 
polypeptide OTTMUSP00000005324 VEGA | MGI Sequence Detail 666 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(26) UniProt(12)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(424 from dbSNP Build 137)    SNPs within 2kb including multiple locations(428)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003200 calcium/calmodulin-dependent protein kinase type II subunit beta
References
(Earliest) J:1487 Karls U, et al., Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant. Mol Cell Biol. 1992 Aug;12(8):3644-52
(Latest) J:219040 Bachstetter AD, et al., Generation and behavior characterization of CaMKIIbeta knockout mice. PLoS One. 2014;9(8):e105191
All references(68)
Other
accession IDs
MGD-MRK-1744

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory