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Camk2b
Gene Detail
Symbol

Name
ID
Camk2b
calcium/calmodulin-dependent protein kinase II, beta
MGI:88257
Synonyms
CaMK II
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr11:5969644-6066362 bp, - strand
From VEGA annotation of GRCm38

  96719 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:111050  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: calcium/calmodulin-dependent protein kinase II
Gene Tree: Camk2b

Human
homologs
Human Homolog CAMK2B, calcium/calmodulin-dependent protein kinase II beta
NCBI Gene ID 816
neXtProt AC  NX_Q13554
Human Synonyms  CAM2, CAMK2, CAMKB
Human Chr (Location)  7p14.3-p14.1; chr7:44217150-44325631 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(17) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit reversal of plasticity direction at parallel fiber-Purkinje cell synapses.
 
Interactions
Camk2b interacts with 237 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (314)    Tissues (101)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 268
RT-PCR 46
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) Genomic(2) cDNA(53) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005105 (Evidence)
Ensembl Gene ModelENSMUSG00000057897 (Evidence)
Entrez Gene12323 (Evidence)
UniGene439733
DFCITC1576025, TC1587035, TC1593226, TC1598554, TC1617955, TC1689622
DoTSDT.101148087, DT.101264232, DT.110526260, DT.40169561, DT.94238857, DT.97407095
NIA Mouse Gene IndexU032479
EC2.7.11.17
Consensus CDS ProjectCCDS24411.1, CCDS48748.1, CCDS48749.1
International Mouse Knockout Project StatusCamk2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005105 VEGA Gene Model | MGI Sequence Detail 96719 C57BL/6J ±  kb
transcript OTTMUST00000011425 VEGA | MGI Sequence Detail 2223 Not Applicable 
polypeptide OTTMUSP00000005324 VEGA | MGI Sequence Detail 666 Not Applicable 

For the selected sequences
All sequences(125) RefSeq(40) UniProt(12)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(424 from dbSNP Build 137)    SNPs within 2kb including multiple locations(428)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003200 calcium/calmodulin-dependent protein kinase type II subunit beta
References
(Earliest) J:1487 Karls U, et al., Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant. Mol Cell Biol. 1992 Aug;12(8):3644-52
(Latest) J:207976 Li Q, et al., The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
All references(68)
Other
accession IDs
MGD-MRK-1744

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory