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Camk2b Gene Detail
Summary
  • Symbol
    Camk2b
  • Name
    calcium/calmodulin-dependent protein kinase II, beta
  • Synonyms
    CaMK II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88257
    NCBI Gene: 12323
  • Gene Overview
    MyGene.info: CAMK2B
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5969642-6066125 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.89 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    408 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88257
protein coding gene Chr11:5969642-6066362 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018014
protein coding gene Chr11:3064160-3157810 (-)
A/J MGP_AJ_G0017987
protein coding gene Chr11:2942598-3035624 (-)
AKR/J MGP_AKRJ_G0017951
protein coding gene Chr11:3090570-3185002 (-)
BALB/cJ MGP_BALBcJ_G0017955
protein coding gene Chr11:2930774-3021627 (-)
C3H/HeJ MGP_C3HHeJ_G0017768
protein coding gene Chr11:2965892-3058931 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018407
protein coding gene Chr11:3142571-3242742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016065
protein coding gene Chr11:2839786-2931140 (-)
CAST/EiJ MGP_CASTEiJ_G0017330
protein coding gene Chr11:2938778-3035730 (-)
CBA/J MGP_CBAJ_G0017743
protein coding gene Chr11:3527349-3636328 (-)
DBA/2J MGP_DBA2J_G0017853
protein coding gene Chr11:2846710-2944012 (-)
FVB/NJ MGP_FVBNJ_G0017845
protein coding gene Chr11:2873560-2965267 (-)
LP/J MGP_LPJ_G0017924
protein coding gene Chr11:3141993-3236043 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017871
protein coding gene Chr11:3123927-3217438 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018447
protein coding gene Chr11:3107191-3197665 (-)
PWK/PhJ MGP_PWKPhJ_G0017110
protein coding gene Chr11:2868160-2971593 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016907
protein coding gene Chr11:3063480-3155738 (-)
WSB/EiJ MGP_WSBEiJ_G0017384
protein coding gene Chr11:2939685-3035930 (-)



Homology
more
  • Human Ortholog
    CAMK2B, calcium/calmodulin dependent protein kinase II beta
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CAMK2B, calcium/calmodulin dependent protein kinase II beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAM2, CAMK2, CAMKB, MRD54
  • Links
    NCBI Gene ID: 816
    neXtProt AC: NX_Q13554
    UniProt: Q13554

  • Chr Location
    7p13; chr7:44217150-44325994 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CAMK2B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reversal of plasticity direction at parallel fiber-Purkinje cell synapses. Mice homozygous for a different null allele show motor impairments, including ataxia, altered body mass composition, a reduction in anxiety-related behavior, and cognitive deficits.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12323 NCBI Gene Model | MGI Sequence Detail 96484 C57BL/6J ±  kb
    transcript NM_001174053 RefSeq | MGI Sequence Detail 4034 C57BL/6  
    polypeptide P28652 UniProt | EBI | MGI Sequence Detail 542 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • EC
    • InterPro Domains
      IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
      IPR039071 Calcium/calmodulin-dependent protein kinase type II
      IPR032710 NTF2-like domain superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 2
      cDNA 54
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1744
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 14
      Gene Ontology 16
      Phenotypes 11
    • Earliest
      J:1487 Karls U, et al., Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant. Mol Cell Biol. 1992 Aug;12(8):3644-52
    • Latest
      J:262849 Cook SG, et al., Analysis of the CaMKIIalpha and beta splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep. 2018 Apr 3;8(1):5448

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory