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Calr
Gene Detail
 Symbol
Name
ID
Calr
calreticulin
MGI:88252
Synonyms Calregulin, CRT
Feature Type protein coding gene
Genetic Map
Chromosome 8
41.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:84841850-84846934 bp, - strand
From VEGA annotation of GRCm38

  5085 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37911  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: calreticulin
Gene Tree: Calr

Human
homologs
Human Homolog CALR, calreticulin
NCBI Gene ID 811
neXtProt AC  NX_P27797
Human Synonyms  cC1qR, CRT, HEL-S-99n, RO, SSA
Human Chr (Location)  19p13.3-p13.2; chr19:12938600-12944490 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CALR
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit decreased cardiac cell mass, increased apoptosis of cardiac myocytes, neural tube defects (sometimes associated with exencephaly), omphalocele, and mid- to late-gestational lethality.
 
Phenotype Images(7)
Interactions
Calr interacts with 142 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (76 annotations)
Process cell cycle arrest, cellular senescence, ...
Component acrosomal vesicle, cell surface, ...
Function androgen receptor binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (65)    Tissues (36)    Images (6)
Theiler Stages: 13, 15, 17, 20, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 2
Northern blot 10
Western blot 51
RT-PCR 2
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(12) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022277 (Evidence)
Ensembl Gene ModelENSMUSG00000003814 (Evidence)
Entrez Gene12317 (Evidence)
DFCITC1573828
DoTSDT.55133196, DT.94312868, DT.94312886
NIA Mouse Gene IndexU030041, U115653, U145471
PDB3O0V, 3O0W, 3O0X, 3RG0
Consensus CDS ProjectCCDS22479.1
International Mouse Knockout Project StatusCalr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022277 VEGA Gene Model | MGI Sequence Detail 5085 C57BL/6J ±  kb
transcript OTTMUST00000053061 VEGA | MGI Sequence Detail 2184 Not Applicable 
polypeptide OTTMUSP00000025211 VEGA | MGI Sequence Detail 416 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009169 Calreticulin
InterPro IPR001580 Calreticulin/calnexin
InterPro IPR018124 Calreticulin/calnexin, conserved site
InterPro IPR009033 Calreticulin/calnexin, P domain
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
Protein Ontology PR:000004984 calreticulin
References (Earliest) J:49094 Tuan RS, et al., Identification and characterization of a calcium-binding protein in the mouse chorioallantoic placenta. Biochem J. 1986 Jan 1;233(1):41-9
(Latest) J:206895 Stemmer N, et al., Generation of amyloid-beta is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin. PLoS One. 2013;8(4):e61299
All references(115)
Other
accession IDs
MGD-MRK-1739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory