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Calr Gene Detail
Summary
  • Symbol
    Calr
  • Name
    calreticulin
  • Synonyms
    Calregulin, CRT
  • Feature Type
    protein coding gene
  • IDs
    MGI:88252
    NCBI Gene: 12317
  • Gene Overview
    MyGene.info: CALR
Location & Maps
more
  • Sequence Map
    Chr8:84841850-84846934 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5085 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.21 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CALR, calreticulin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CALR, calreticulin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    cC1qR, CRT, HEL-S-99n, RO, SSA
  • Links
    NCBI Gene ID: 811
    neXtProt AC: NX_P27797

  • Chr Location
    19p13.13; chr19:12938600-12944490 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human CALR associations

Human Disease Mouse Models
       Myelofibrosis   OMIM: 254450
Thrombocythemia 1; THCYT1   OMIM: 187950
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    7 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    12
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Calr
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit decreased cardiac cell mass, increased apoptosis of cardiac myocytes, neural tube defects (sometimes associated with exencephaly), omphalocele, and mid- to late-gestational lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022277 VEGA Gene Model | MGI Sequence Detail 5085 C57BL/6J ±  kb
transcript OTTMUST00000053061 VEGA | MGI Sequence Detail 2184 Not Applicable  
polypeptide OTTMUSP00000025211 VEGA | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 12
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1739
References
more
  • Summaries
    All 120
    Developmental Gene Expression 27
    Gene Ontology 28
    Phenotypes 49
  • Earliest
    J:49094 Tuan RS, et al., Identification and characterization of a calcium-binding protein in the mouse chorioallantoic placenta. Biochem J. 1986 Jan 1;233(1):41-9
  • Latest
    J:231655 Barber M, et al., Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Controls the Size of Higher-Order Cortical Areas. Curr Biol. 2015 Oct 5;25(19):2466-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory