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Phenotypes Associated with This Genotype
Genotype
MGI:6108900
Allelic
Composition
Tg(CAG-Calr)#Mlk/0
Tg(Myh6-cre/Esr1*)1Liao/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• tamoxifen-treated mice exhibit enlarged cardiac chambers
• as early as 1 week after tamoxifen treatment, less than 30% of mice show dilatation of the left ventricle chamber
• adult hearts of tamoxifen treated mice exhibit enlarged left ventricle chamber with thinned posterior wall
• tamoxifen-treated mice develop severe cardiac fibrosis
• treatment of tamoxifen-induced mice with TUDCA, the taurine-conjugated form of ursodeoxycholic acid, reduces cardiac fibrosis
• in tamoxifen-treated mice
• as early as 1 week after tamoxifen treatment, less than 30% of mice show reduced percent ejection fraction
• echocardiography of tamoxifen-induced mice indicates severe left ventricle dilation, increase in left ventricle internal dimension, decreased systolic function of the left ventricle, and increased Tci index of the left ventricle, an indicator of systolic and diastolic function, prolongation of the isovolumic intervals and shortening of ejection fraction
• absence of A-wave indicating a restricted pattern of transmitral flow velocity
• tamoxifen-treated mice show a longer PR interval indicating prolonged AV conduction
• P wave amplitude as a proportion of the QRS amplitude is increased in tamoxifen-treated mice
• QRS amplitude is reduced in tamoxifen-treated mice
• tamoxifen-treated mice exhibit a weak T amplitude of electrical impulse
• in tamoxifen-treated mice

growth/size/body
• tamoxifen-treated mice exhibit enlarged cardiac chambers
• in tamoxifen-treated mice

muscle
• in tamoxifen-treated mice
• as early as 1 week after tamoxifen treatment, less than 30% of mice show reduced percent ejection fraction

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congestive heart failure DOID:6000 J:253065


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory