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Atf4 Gene Detail
Summary
  • Symbol
    Atf4
  • Name
    activating transcription factor 4
  • Synonyms
    Atf-4, C/ATF, CREB2, TAXREB67
  • Feature Type
    protein coding gene
  • IDs
    MGI:88096
    NCBI Gene: 11911
Location & Maps
more
  • Sequence Map
    Chr15:80255184-80257540 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2357 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ATF4, activating transcription factor 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ATF4, activating transcription factor 4
    Orthology source: HomoloGene
  • Synonyms
    CREB2, CREB-2, TAXREB67, TXREB
  • Links
    NCBI Gene ID: 468
    neXtProt AC: NX_P18848

  • Chr Location
    22q13.1; chr22:39520559-39522686 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 8 alleles in 10 genetic backgrounds
    13 phenotypes from multigenic genotypes
    2 images
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    8
  • Transgenic
    3
  • Genomic Mutations
    3 involving Atf4
  • Incidental Mutations
Mice homozygous for one knock-out allele exhibit postnatal lethality, abnormal lens development, and reduced male fertility. Mice homozygous for a different knock-out allele exhibit abnormal pancreatic and skeletal development, glucose homeostasis, and insulin homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042406 Ensembl Gene Model | MGI Sequence Detail 2357 C57BL/6J ±  kb
transcript ENSMUST00000109605 Ensembl | MGI Sequence Detail 1724 Not Applicable  
polypeptide ENSMUSP00000105234 Ensembl | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    55 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000004400 cyclic AMP-dependent transcription factor ATF-4
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR029811 cAMP-dependent transcription factor ATF-4
Molecular
Reagents
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  • All nucleic 344
    cDNA 339
    Primer pair 5

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1444, MGD-MRK-1445
References
more
  • Summaries
    All 150
    Developmental Gene Expression 41
    Diseases 1
    Gene Ontology 25
    Phenotypes 73
  • Earliest
    J:2327 Mielnicki LM, et al., Isolation and nucleotide sequence of a murine cDNA homologous to human activating transcription factor 4. Nucleic Acids Res. 1991 Nov 25;19(22):6332
  • Latest
    J:222854 Laguna A, et al., Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nat Neurosci. 2015 Jun;18(6):826-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory