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Atf4 Gene Detail
Summary
  • Symbol
    Atf4
  • Name
    activating transcription factor 4
  • Synonyms
    Atf-4, C/ATF, CREB2, TAXREB67
  • Feature Type
    protein coding gene
  • IDs
    MGI:88096
    NCBI Gene: 11911
  • Gene Overview
    MyGene.info: ATF4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:80255184-80257541 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2358 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.85 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    ATF4, activating transcription factor 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ATF4, activating transcription factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CREB2, CREB-2, TAXREB67, TXREB
  • Links
    NCBI Gene ID: 468
    neXtProt AC: NX_P18848
    UniProt: P18848

  • Chr Location
    22q13.1; chr22:39519709-39522686 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 9 alleles in 12 genetic backgrounds
    16 phenotypes from multigenic genotypes
    4 images
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit postnatal lethality, abnormal lens development, and reduced male fertility. Mice homozygous for a different knock-out allele exhibit abnormal pancreatic and skeletal development, glucose homeostasis, and insulin homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042406 Ensembl Gene Model | MGI Sequence Detail 2358 C57BL/6J ±  kb
    transcript ENSMUST00000109605 Ensembl | MGI Sequence Detail 1725 Not Applicable  
    polypeptide ENSMUSP00000105234 Ensembl | MGI Sequence Detail 349 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      53 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 348
      cDNA 341
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1444, MGD-MRK-1445
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 54
      Diseases 1
      Gene Ontology 28
      Phenotypes 89
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:262162 Ord T, et al., TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP-ATF response elements in the Fgf21 promoter. Biochim Biophys Acta. 2018 Mar;1861(3):271-281

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory