About   Help   FAQ
Atf4
Gene Detail
 Symbol
Name
ID
Atf4
activating transcription factor 4
MGI:88096
Synonyms Atf-4, C/ATF, CREB2, TAXREB67
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:80255184-80257540 bp, + strand
From Ensembl annotation of GRCm38

  2357 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: cyclic AMP-dependent transcription factor, ATF4 type
Gene Tree: Atf4

Human
homologs
Human Homolog ATF4, activating transcription factor 4
NCBI Gene ID 468
neXtProt AC  NX_P18848
Human Synonyms  CREB2, CREB-2, TAXREB67, TXREB
Human Chr (Location)  22q13.1; chr22:39520564-39522686 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Radiation induced(1) Targeted(6)
Genomic Mutations involving Atf4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele exhibit postnatal lethality, abnormal lens development, and reduced male fertility. Mice homozygous for a different knock-out allele exhibit abnormal pancreatic and skeletal development, glucose homeostasis, and insulin homeostasis.
 
Phenotype Images(1)
Interactions
Atf4 interacts with 22 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process circadian regulation of gene expression, gamma-aminobutyric acid signaling pathway, ...
Component cytoplasm, cytoskeleton, ...
Function core promoter sequence-specific DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (246)    Tissues (210)    Images (39)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 16
RNA in situ 195
Northern blot 2
Western blot 9
RT-PCR 24
cDNA source data(338)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(344) cDNA(339) Primer pair(5)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000042406 (Evidence)
Entrez Gene11911 (Evidence)
UniGene641
DFCITC1573096, TC1629075, TC1769025
DoTSDT.101738442, DT.496217, DT.94367139, DT.94367156
NIA Mouse Gene IndexU016447
Consensus CDS ProjectCCDS37145.1
International Mouse Knockout Project StatusAtf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042406 Ensembl Gene Model | MGI Sequence Detail 2357 C57BL/6J ±  kb
transcript ENSMUST00000109605 Ensembl | MGI Sequence Detail 1724 Not Applicable 
polypeptide ENSMUSP00000105234 Ensembl | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(6)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
Protein Ontology PR:000004400 cyclic AMP-dependent transcription factor ATF-4
References (Earliest) J:2327 Mielnicki LM, et al., Isolation and nucleotide sequence of a murine cDNA homologous to human activating transcription factor 4. Nucleic Acids Res. 1991 Nov 25;19(22):6332
(Latest) J:208924 Iwasaki Y, et al., Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages. Diabetes. 2014 Jan;63(1):152-61
All references(139)
Other
accession IDs
MGD-MRK-1444, MGD-MRK-1445

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory