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Ace Gene Detail
Summary
  • Symbol
    Ace
  • Name
    angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
  • Synonyms
    CD143
  • Feature Type
    protein coding gene
  • IDs
    MGI:87874
    NCBI Gene: 11421
  • Gene Overview
    MyGene.info: ACE
Location & Maps
more
  • Sequence Map
    Chr11:105967945-105989964 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22020 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 68.84 cM
  • Mapping Data
    3 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    ACE, angiotensin I converting enzyme
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACE, angiotensin I converting enzyme
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACE1, CD143, DCP, DCP1
  • Links
    NCBI Gene ID: 1636
    neXtProt AC: NX_P12821

  • Chr Location
    17q23.3; chr17:63477061-63498380 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    5 with human ACE associations

Human Disease Mouse Models
       Alzheimer Disease; AD   OMIM: 104300
Angiotensin I-Converting Enzyme; ACE   OMIM: 106180
Hemorrhage, Intracerebral, Susceptibility To; ICH   OMIM: 614519
Microvascular Complications of Diabetes, Susceptibility to, 3; MVCD3   OMIM: 612624
Renal Tubular Dysgenesis; RTD   OMIM: 267430
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    84 phenotypes from 15 alleles in 13 genetic backgrounds
    10 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a number of different targeted mutations show variable phenotypes, including reduced systemic blood pressure, normocytic anemia, renal abnormalities, inability to concentrate urine, and reduced male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003113 VEGA Gene Model | MGI Sequence Detail 22020 C57BL/6J ±  kb
transcript OTTMUST00000006415 VEGA | MGI Sequence Detail 4906 Not Applicable  
polypeptide OTTMUSP00000003021 VEGA | MGI Sequence Detail 1312 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    98 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 31
    Genomic 6
    cDNA 24
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1032, MGI:2144508
References
more
  • Summaries
    All 125
    Developmental Gene Expression 11
    Gene Ontology 14
    Phenotypes 65
  • Earliest
    J:21460 Bernstein KE, et al., The isolation of angiotensin-converting enzyme cDNA. J Biol Chem. 1988 Aug 15;263(23):11021-4
  • Latest
    J:218046 Cuffe JS, et al., The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. Placenta. 2014 Nov;35(11):953-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory