Ace MGI Mouse Gene Detail - MGI:87874 - angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

Symbol

Ace
Name

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Synonyms

CD143

Feature Type

protein coding gene
IDs

MGI:87874
NCBI Gene: 11421
Gene Overview

MyGene.info: ACE
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:105967945-105989964 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 68.84 cM
Mapping Data

3 experiments
Sequence Tag

D11Mit13

SNPs within 2kb

98 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87874	protein coding gene	Chr11:105967945-105989964 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0019288	protein coding gene	Chr11:109234278-109257791 (+)
A/J	MGP_AJ_G0019256	protein coding gene	Chr11:104589333-104610930 (+)
AKR/J	MGP_AKRJ_G0019225	protein coding gene	Chr11:107712236-107735979 (+)
BALB/cJ	MGP_BALBcJ_G0019230	protein coding gene	Chr11:104993314-105015443 (+)
C3H/HeJ	MGP_C3HHeJ_G0019039	protein coding gene	Chr11:108005982-108028584 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019680	protein coding gene	Chr11:112589859-112613898 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017305	protein coding gene	Chr11:101880015-101901439 (+)
CAST/EiJ	MGP_CASTEiJ_G0018592	protein coding gene	Chr11:109055386-109079503 (+)
CBA/J	MGP_CBAJ_G0019008	protein coding gene	Chr11:117277000-117301247 (+)
DBA/2J	MGP_DBA2J_G0019120	protein coding gene	Chr11:104064547-104086368 (+)
FVB/NJ	MGP_FVBNJ_G0019111	protein coding gene	Chr11:103568038-103590303 (+)
LP/J	MGP_LPJ_G0019190	protein coding gene	Chr11:109688724-109712120 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019141	protein coding gene	Chr11:116570951-116598788 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019717	protein coding gene	Chr11:108196014-108217538 (+)
PWK/PhJ	MGP_PWKPhJ_G0018357	protein coding gene	Chr11:105156672-105179568 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018148	protein coding gene	Chr11:107966872-107992726 (+)
WSB/EiJ	MGP_WSBEiJ_G0018643	protein coding gene	Chr11:108168464-108191086 (+)

Human Ortholog

ACE, angiotensin I converting enzyme

Vertebrate Orthologs

10

Human Ortholog

ACE, angiotensin I converting enzyme
Orthology source: HGNC, HomoloGene
Synonyms

ACE1, CD143, DCP, DCP1
Links

HGNC:2707

NCBI Gene ID: 1636

neXtProt AC: NX_P12821

UniProt: P12821
Chr Location

17q23.3; chr17:63477061-63498380 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 37351
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ACE
Protein SuperFamily

angiotensin-converting enzyme, somatic isoform
Gene Tree

Ace

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Phenotype Summary

84 phenotypes from 15 alleles in 13 genetic backgrounds
10 phenotypes from multigenic genotypes
66 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Targeted

18
Transgenic

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a number of different targeted mutations show variable phenotypes, including reduced systemic blood pressure, normocytic anemia, renal abnormalities, inability to concentrate urine, and reduced male fertility.

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All GO Annotations

107
GO References

15

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

218
Tissues

124
cDNA Data

25
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ACE

Xenbase ace

ZFIN ace

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Ace interacts with 160 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

59
RefSeq

6
UniProt

8
CCDS

CCDS25543.1, CCDS25544.1

Ensembl

ENSMUSG00000020681 (Evidence)
NCBI Gene

11421

			Length	Strain/Species	Flank
genomic	11421	NCBI Gene Model \| MGI Sequence Detail	22020	C57BL/6J	± kb
transcript	NM_001281819	RefSeq \| MGI Sequence Detail	5091	C57BL/6
polypeptide	P09470	UniProt \| EBI \| MGI Sequence Detail	1312	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000001322 angiotensin-converting enzyme

(term hierarchy)
EC

3.2.1.-, 3.4.-.-, 3.4.15.1
InterPro Domains

IPR001548 Peptidase M2, peptidyl-dipeptidase A

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All nucleic 34

Genomic 6

cDNA 26

Primer pair 1

Other 1

Microarray probesets 5

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MGD-MRK-1032, MGI:2144508

Summaries

All 142

Developmental Gene Expression 16

Gene Ontology 15

Phenotypes 66
Earliest

J:21460 Bernstein KE, et al., The isolation of angiotensin-converting enzyme cDNA. J Biol Chem. 1988 Aug 15;263(23):11021-4
Latest

J:263836 Srivillibhuthur M, et al., TFAM is required for maturation of the fetal and adult intestinal epithelium. Dev Biol. 2018 Jul 15;439(2):92-101

TSS for Ace:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105461	Chr11:105967642-105967662 (+)	-293 bp
Tssr105462	Chr11:105967914-105967927 (+)	-24 bp
Tssr105463	Chr11:105967938-105967956 (+)	2 bp
Tssr105464	Chr11:105968515-105968523 (+)	574 bp
Tssr105468	Chr11:105975181-105975195 (+)	7,243 bp
Tssr105469	Chr11:105975204-105975215 (+)	7,265 bp
Tssr3701	Chr11:105975220-105975227 (+)	7,279 bp
Tssr105470	Chr11:105985737-105985751 (+)	17,799 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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