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Ace Gene Detail
Summary
  • Symbol
    Ace
  • Name
    angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
  • Synonyms
    CD143
  • Feature Type
    protein coding gene
  • IDs
    MGI:87874
    NCBI Gene: 11421
  • Gene Overview
    MyGene.info: ACE
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:105967945-105989964 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      22020 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 68.84 cM
  • Mapping Data
    3 experiments
  • Sequence Tag
    D11Mit13
Homology
more
  • Human Ortholog
    ACE, angiotensin I converting enzyme
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACE, angiotensin I converting enzyme
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACE1, CD143, DCP, DCP1
  • Links
    NCBI Gene ID: 1636
    neXtProt AC: NX_P12821
    UniProt: P12821

  • Chr Location
    17q23.3; chr17:63477061-63498380 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human ACE associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    84 phenotypes from 15 alleles in 13 genetic backgrounds
    10 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a number of different targeted mutations show variable phenotypes, including reduced systemic blood pressure, normocytic anemia, renal abnormalities, inability to concentrate urine, and reduced male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    98
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    218
  • Tissues
    124
  • cDNA Data
    25
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003113 VEGA Gene Model | MGI Sequence Detail 22020 C57BL/6J ±  kb
    transcript OTTMUST00000006415 VEGA | MGI Sequence Detail 4906 Not Applicable  
    polypeptide OTTMUSP00000003021 VEGA | MGI Sequence Detail 1312 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      98 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 6
      cDNA 26
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1032, MGI:2144508
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 16
      Gene Ontology 14
      Phenotypes 66
    • Earliest
      J:21460 Bernstein KE, et al., The isolation of angiotensin-converting enzyme cDNA. J Biol Chem. 1988 Aug 15;263(23):11021-4
    • Latest
      J:263836 Srivillibhuthur M, et al., TFAM is required for maturation of the fetal and adult intestinal epithelium. Dev Biol. 2018 Jul 15;439(2):92-101
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory