Ace
Gene Detail

Symbol

Name
ID

Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
MGI:87874

STS

D11Mit13

Synonyms

CD143

Feature Type

protein coding gene

Genetic Map

Chromosome 11
68.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:105967945-105989964 bp, + strand From VEGA annotation of GRCm38   22020 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:37351  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: angiotensin-converting enzyme, somatic isoform
Gene Tree: Ace

Human
homologs

Human Homolog		ACE, angiotensin I converting enzyme
NCBI Gene ID		1636
neXtProt AC		NX_P12821
Human Synonyms		ACE1, CD143, DCP, DCP1, ICH, MVCD3
Human Chr (Location)		17q23.3; chr17:63477061-63498380 (+)  GRCh38
Disease Associations		(5) Diseases Associated with Human ACE

Mutations,
alleles, and
phenotypes

All mutations/alleles(16) : Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a number of different targeted mutations show variable phenotypes, including reduced systemic blood pressure, normocytic anemia, renal abnormalities, inability to concentrate urine, and reduced male fertility.

 

Interactions

Ace interacts with 161 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (96 annotations)

Process	angiogenesis involved in coronary vascular morphogenesis, arachidonic acid secretion, ...
Component	basal plasma membrane, brush border membrane, ...
Function	actin binding, amylase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)

Data Summary: Results (207)    Tissues (120)    Images (28)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	161
RT-PCR	46

cDNA source data(126)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(134) Genomic(6) cDNA(127) Primer pair(1)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000003113 (Evidence)
Ensembl Gene Model	ENSMUSG00000020681 (Evidence)
Entrez Gene	11421 (Evidence)
UniGene	754
DFCI	TC1578619, TC1588641, TC1597179
DoTS	DT.40186624, DT.97340483, DT.97393465, DT.97393466
NIA Mouse Gene Index	U013459
EC	3.2.1.-, 3.4.15.1
Consensus CDS Project	CCDS25543.1, CCDS25544.1
International Mouse Knockout Project Status	Ace

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003113	VEGA Gene Model | MGI Sequence Detail	22020	C57BL/6J
transcript	OTTMUST00000006415	VEGA | MGI Sequence Detail	4906	Not Applicable
polypeptide	OTTMUSP00000003021	VEGA | MGI Sequence Detail	1312	Not Applicable

All sequences(57) RefSeq(6) UniProt(8)

Polymorphisms

SNPs within 2kb(101 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001548	Peptidase M2, peptidyl-dipeptidase A
Protein Ontology	PR:000001322	angiotensin-converting enzyme

References

(Earliest) J:21460 Bernstein KE, et al., The isolation of angiotensin-converting enzyme cDNA. J Biol Chem. 1988 Aug 15;263(23):11021-4
(Latest) J:215922 Yang KC, et al., Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase. Circ Arrhythm Electrophysiol. 2014 Aug;7(4):701-10
All references(124)

Other
accession IDs

MGD-MRK-1032, MGI:2144508