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Ace
Gene Detail
Symbol

Name
ID
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
MGI:87874
STS
Synonyms
CD143
Feature Type
protein coding gene
Genetic Map
Chromosome 11
68.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:105967945-105989964 bp, + strand
From VEGA annotation of GRCm38

  22020 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37351  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACE
Protein SuperFamily: angiotensin-converting enzyme, somatic isoform
Gene Tree: Ace

Human
homologs
ACE, angiotensin I converting enzyme
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1636
neXtProt AC: NX_P12821

Human Synonyms: ACE1, CD143, DCP, DCP1, ICH, MVCD3

Human Chr (Location): 17q23.3; chr17:63477061-63498380 (+)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human ACE

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Targeted(16)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a number of different targeted mutations show variable phenotypes, including reduced systemic blood pressure, normocytic anemia, renal abnormalities, inability to concentrate urine, and reduced male fertility.
 
Interactions
Ace interacts with 160 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (96 annotations)
Process angiogenesis involved in coronary vascular morphogenesis, arachidonic acid secretion, ...
Component basal plasma membrane, brush border membrane, ...
Function actin binding, amylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (207)    Tissues (120)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 161
RT-PCR 46
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ACE ; Xenbase ace ; ZFIN ace    NEW 
Molecular
reagents
All nucleic(31) Genomic(6) cDNA(24) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000003113 (Evidence)
Ensembl Gene Model ENSMUSG00000020681 (Evidence)
Entrez Gene 11421 (Evidence)
DoTS DT.40186624, DT.97340483, DT.97393465, DT.97393466
NIA Mouse Gene Index U013459
EC 3.2.1.-, 3.4.15.1
Consensus CDS Project CCDS25543.1, CCDS25544.1
International Mouse Phenotyping Consortium Status Ace
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003113 VEGA Gene Model | MGI Sequence Detail 22020 C57BL/6J ±  kb
transcript OTTMUST00000006415 VEGA | MGI Sequence Detail 4906 Not Applicable 
polypeptide OTTMUSP00000003021 VEGA | MGI Sequence Detail 1312 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(8)
Polymorphisms
SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001548 Peptidase M2, peptidyl-dipeptidase A
Protein Ontology PR:000001322 angiotensin-converting enzyme
References
(Earliest) J:21460 Bernstein KE, et al., The isolation of angiotensin-converting enzyme cDNA. J Biol Chem. 1988 Aug 15;263(23):11021-4
(Latest) J:218046 Cuffe JS, et al., The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. Placenta. 2014 Nov;35(11):953-61
All references(125)
Other
accession IDs
MGD-MRK-1032, MGI:2144508

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory