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Ace
Gene Detail
 Symbol
Name
ID
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
MGI:87874
STS D11Mit13
Synonyms CD143
Feature Type protein coding gene
Genetic Map
Chromosome 11
68.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:105967945-105989964 bp, + strand
From VEGA annotation of GRCm38

  22020 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37351  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: angiotensin-converting enzyme, somatic isoform
Gene Tree: Ace

Human
homologs
Human Homolog ACE, angiotensin I converting enzyme
NCBI Gene ID 1636
neXtProt AC  NX_P12821
Human Synonyms  ACE1, CD143, DCP, DCP1, ICH, MVCD3
Human Chr (Location)  17q23.3; chr17:63477061-63498380 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human ACE
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a number of different targeted mutations show variable phenotypes, including reduced systemic blood pressure, normocytic anemia, renal abnormalities, inability to concentrate urine, and reduced male fertility.
 
Interactions
Ace interacts with 161 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (77 annotations)
Process angiogenesis involved in coronary vascular morphogenesis, arachidonic acid secretion, ...
Component basal plasma membrane, brush border membrane, ...
Function actin binding, amylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (207)    Tissues (120)    Images (28)
Theiler Stages: 22, 23, 26, 28
Assay TypeResults
RNA in situ 161
RT-PCR 46
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(6) cDNA(24) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003113 (Evidence)
Ensembl Gene ModelENSMUSG00000020681 (Evidence)
Entrez Gene11421 (Evidence)
DoTSDT.40186624, DT.97340483, DT.97393465, DT.97393466
NIA Mouse Gene IndexU013459
EC3.2.1.-, 3.4.15.1
Consensus CDS ProjectCCDS25543.1, CCDS25544.1
International Mouse Knockout Project StatusAce
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003113 VEGA Gene Model | MGI Sequence Detail 22020 C57BL/6J ±  kb
transcript OTTMUST00000006415 VEGA | MGI Sequence Detail 4906 Not Applicable 
polypeptide OTTMUSP00000003021 VEGA | MGI Sequence Detail 1312 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(8)
Polymorphisms SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001548 Peptidase M2, peptidyl-dipeptidase A
Protein Ontology PR:000001322 angiotensin-converting enzyme
References (Earliest) J:21460 Bernstein KE, et al., The isolation of angiotensin-converting enzyme cDNA. J Biol Chem. 1988 Aug 15;263(23):11021-4
(Latest) J:208134 Shen XZ, et al., Myeloid expression of angiotensin-converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells. Lab Invest. 2014 May;94(5):536-44
All references(118)
Other
accession IDs
MGD-MRK-1032, MGI:2144508

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory