Ace Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ace
angiotensin I converting enzyme
MGI:87874

34 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ace^tm1Keb/Ace^tm5Keb involves: 129S1/Sv * 129X1/SvJ	decreased angiotensin I-converting enzyme activity	J:89512
Ace^tm1Keb/Ace^tm5Keb involves: 129S1/Sv * 129X1/SvJ	increased circulating renin level	J:89512
Ace^tm1Unc/Ace^tm1Unc Ace2^tm1Pngr/Y involves: 129P2/OlaHsd	abnormal kidney morphology	J:77232
	decreased angiotensin II level	J:100334
	decreased circulating angiotensin II level	J:100334
	decreased susceptibility to injury	J:100334
	hypotension	J:77232
Ace^tm1Unc/Ace^tm1Unc Ace2^tm1Pngr/Ace2^tm1Pngr involves: 129P2/OlaHsd	abnormal kidney morphology	J:77232
	decreased angiotensin II level	J:100334
	decreased circulating angiotensin II level	J:100334
	decreased susceptibility to injury	J:100334
	hypotension	J:77232
Ace^tm3Unc/Ace⁺ B6.129P2-Ace^tm3Unc	albuminuria	J:72577
Ace^tm3Unc/Ace⁺ B6.129P2-Ace^tm3Unc	increased systemic arterial blood pressure	J:72577
Ace^tm3Unc/Ace⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal epididymal fat pad morphology	J:128859
	abnormal kidney cortex morphology	J:42519
	abnormal renal glomerulus morphology	J:42519
	decreased body weight	J:128859
	decreased heart rate	J:42519
	decreased heart weight	J:42519
	decreased insulin secretion	J:128859
	increased food intake	J:128859
Ace^tm3Unc/Ace^tm3Unc involves: 129P2/OlaHsd * C57BL/6J	abnormal kidney cortex morphology	J:42519
	abnormal renal glomerulus morphology	J:42519
	decreased heart rate	J:42519
	decreased heart weight	J:42519
Ace^tm4Keb/Ace^tm4Keb Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	abnormal kidney vasculature morphology	J:83894
	abnormal response/metabolism to endogenous compounds	J:83894
	decreased hematocrit	J:83894
	decreased kidney weight	J:83894
	decreased systemic arterial systolic blood pressure	J:83894
	decreased urine osmolality	J:83894
	kidney cyst	J:83894
	vascular inflammation	J:83894
Ace^tm5Keb/Ace^tm5Keb involves: 129S1/Sv * 129X1/SvJ	normal cardiovascular system phenotype	J:89512
	decreased angiotensin I-converting enzyme activity	J:89512
	normal homeostasis/metabolism phenotype	J:163902
	normal renal/urinary system phenotype	J:89512
Ace^tm5Keb/Ace^tm5Keb involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased susceptibility to injury	J:163454
	decreased susceptibility to xenobiotic induced morbidity/mortality	J:163454
	increased angiotensin I-converting enzyme activity	J:163454
Ace^tm6Keb/Ace⁺ involves: 129 * C57BL/6	decreased tumor growth/size	J:122178
Ace^tm6Keb/Ace^tm6Keb involves: 129 * C57BL/6	abnormal interleukin level	J:122178
	abnormal tumor morphology	J:122178
	decreased tumor growth/size	J:122178
	increased T cell number	J:122178
Ace^tm6Keb/Ace^tm6Keb involves: 129 * C57BL/6 * CD-1	decreased tumor growth/size	J:122178

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23