Ace^tm1Keb
Targeted Allele Detail

Summary

• Symbol: Ace^tm1Keb
• Name: angiotensin I converting enzyme; targeted mutation 1, Kenneth E Bernstein
• MGI ID: MGI:2155954
• Synonyms: ACE.1 KO, ACE-KO
• Gene: Ace Location: Chr11:105858774-105880790 bp, + strand Genetic Position: Chr11, 68.84 cM
• Alliance: Ace^tm1Keb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33018
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified isoform(s), Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced part of intron 12 and part of the testis-specific exon. These sequences included the testis specific promoter and the testis specific translational start site. Expression of the somatic isoform of the protein is also disrupted. Protein activity assays confirmed the absence of functional protein in serum, lung, kidney and testis in homozygous mice. (J:33018)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace Mutation: 54 strains or lines available

References

• Original: J:33018 Esther CR Jr, et al., Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest. 1996 May;74(5):953-65
• All: 15 reference(s)