Bdkrb2^tm1Jfh
Targeted Allele Detail

Summary

• Symbol: Bdkrb2^tm1Jfh
• Name: bradykinin receptor, beta 2; targeted mutation 1, J Fred Hess
• MGI ID: MGI:1857135
• Synonyms: B2-, B2-KO, B2R-, BdkrB2, Bk2r-, Bk B2R-, rB2 ^-
• Gene: Bdkrb2 Location: Chr12:105529485-105561496 bp, + strand Genetic Position: Chr12, 55.76 cM
• Alliance: Bdkrb2^tm1Jfh page

Histological changes in the postischemic kidneys of wild type, Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh and MGI:3710159/MGI:3710159 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25953
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the entire coding sequences of the gene. Binding assays on membranes prepared from ileum tissue of homozygous mice confirmed that no functional protein is produced from this allele. (J:25953)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Bdkrb2 Mutation: 25 strains or lines available

References

• Original: J:25953 Borkowski JA, et al., Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J Biol Chem. 1995 Jun 9;270(23):13706-10
• All: 88 reference(s)