Ace^tm6Keb
Targeted Allele Detail

Summary

• Symbol: Ace^tm6Keb
• Name: angiotensin I converting enzyme; targeted mutation 6, Kenneth E Bernstein
• MGI ID: MGI:3713781
• Synonyms: ACE.10
• Gene: Ace Location: Chr11:105858774-105880790 bp, + strand Genetic Position: Chr11, 68.84 cM
• Alliance: Ace^tm6Keb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122178
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 7.2 kb fragment of DNA encoding the mouse colony stimulating factor 1 receptor promoter, first and second exons and the first and second introns was inserted into the locus. The promoter had been modified so that the translation start site normally present in exon 2 was nonfunctional. (J:122178)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace Mutation: 54 strains or lines available

References

• Original: J:122178 Shen XZ, et al., Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Am J Pathol. 2007 Jun;170(6):2122-34
• All: 11 reference(s)