Phenotypes Associated with This Genotype

Genotype
MGI:8474011

• Allelic Composition: Ace^em1Vas/Ace^em1Vas
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:296595 , J:296595 )

♀ • at age 18 months (J:296595)

♂ • at age 18 months (J:296595)

impaired cued conditioning behavior ( J:296595 , J:296595 )

♀ • at age 18 months (J:296595)

♂ • at age 18 months (J:296595)

impaired spatial learning ( J:296595 , J:296595 , J:296595 )

• reduced platform crossings and quadrant time on Morris water maze test trial day at age 18 months (J:296595)

♀ • delayed learning on Morris water maze test training day 4 at age 18 months (J:296595)

♂ • normal learning during Morris water maze test training days at age 18 months (J:296595)

cardiovascular system

cardiovascular system phenotype ( J:296595 )

N • normal blood pressure at ages 8 and 14 months and cerebrovascular function at age 12 months

cellular

increased neuron apoptosis ( J:296595 )

• increased apoptosis of primary forebrain neurons

immune system

brain inflammation ( J:296595 )

• in hippocampus at age 14 months

nervous system

increased neuron apoptosis ( J:296595 )

• increased apoptosis of primary forebrain neurons

brain inflammation ( J:296595 )

• in hippocampus at age 14 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:296595