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Piezo1 Gene Detail
Summary
  • Symbol
    Piezo1
  • Name
    piezo-type mechanosensitive ion channel component 1
  • Synonyms
    Fam38a, Piezo1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3603204
    NCBI Gene: 234839
  • Gene Overview
    MyGene.info: PIEZO1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:122481698-122551329 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 71.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    747 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3603204
protein coding gene Chr8:122481698-122551657 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034229
protein coding gene Chr8:126024529-126099280 (-)
A/J MGP_AJ_G0034209
protein coding gene Chr8:120806488-120877561 (-)
AKR/J MGP_AKRJ_G0034136
protein coding gene Chr8:124324986-124399367 (-)
BALB/cJ MGP_BALBcJ_G0034203
protein coding gene Chr8:121007477-121077989 (-)
C3H/HeJ MGP_C3HHeJ_G0033914
protein coding gene Chr8:125023250-125095671 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034723
protein coding gene Chr8:130224980-130308958 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031665
protein coding gene Chr8:113641274-113714746 (-)
CAST/EiJ MGP_CASTEiJ_G0033241
protein coding gene Chr8:125103974-125177885 (-)
CBA/J MGP_CBAJ_G0033887
protein coding gene Chr8:135016850-135095527 (-)
DBA/2J MGP_DBA2J_G0034043
protein coding gene Chr8:119997436-120067712 (-)
FVB/NJ MGP_FVBNJ_G0033986
protein coding gene Chr8:119141097-119214244 (-)
LP/J MGP_LPJ_G0034132
protein coding gene Chr8:126148246-126221333 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034033
protein coding gene Chr8:137192346-137266185 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034741
protein coding gene Chr8:124508570-124582040 (-)
PWK/PhJ MGP_PWKPhJ_G0032943
protein coding gene Chr8:119818531-119889942 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032783
protein coding gene Chr8:123233146-123307780 (-)
WSB/EiJ MGP_WSBEiJ_G0033357
protein coding gene Chr8:125265980-125337521 (-)



Homology
more
  • Human Ortholog
    PIEZO1, piezo type mechanosensitive ion channel component 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIEZO1, piezo type mechanosensitive ion channel component 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DHS, FAM38A, LMPH3, Mib
  • Links
    NCBI Gene ID: 9780
    neXtProt AC: NX_Q92508
    UniProt: Q92508

  • Chr Location
    16q24.3; chr16:88715338-88785220 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 5 alleles in 4 genetic backgrounds
    3 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Most mice homozygous for a gene trapped allele die at midgestation, exhibiting embryonic growth retardation, pericardial effusion, and vascular remodeling defects in the yolk sac and the embryo proper.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014444 Ensembl Gene Model | MGI Sequence Detail 69632 C57BL/6J ±  kb
    transcript ENSMUST00000156333 Ensembl | MGI Sequence Detail 8219 Not Applicable  
    polypeptide ENSMUSP00000114584 Ensembl | MGI Sequence Detail 2547 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:261124 Ma S, et al., Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell. 2018 Apr 5;173(2):443-455.e12

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory