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Pram1 Gene Detail
Summary
  • Symbol
    Pram1
  • Name
    PML-RAR alpha-regulated adaptor molecule 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3576625
    NCBI Gene: 378460
  • Gene Overview
    MyGene.info: PRAM1
Location & Maps
more
  • Sequence Map
    Chr17:33638056-33645706 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7651 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PRAM1, PML-RARA regulated adaptor molecule 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PRAM1, PML-RARA regulated adaptor molecule 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PML-RAR, PRAM-1
  • Links
    NCBI Gene ID: 84106
    neXtProt AC: NX_Q96QH2

  • Chr Location
    19p13.2; chr19:8490055-8502654 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have neutrophils that exhibit decreased adhesion-dependent reactive oxygen intermediate production and degranulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036515 VEGA Gene Model | MGI Sequence Detail 7651 C57BL/6J ±  kb
transcript OTTMUST00000093637 VEGA | MGI Sequence Detail 2278 Not Applicable  
polypeptide OTTMUSP00000051995 VEGA | MGI Sequence Detail 675 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    63 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013169 PML-RARA-regulated adapter molecule 1
  • InterPro Domains
    IPR029294 Helically-extended SH3 domain
    IPR001452 SH3 domain
Molecular
Reagents
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  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 21
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:95253 Clemens RA, et al., PRAM-1 is required for optimal integrin-dependent neutrophil function. Mol Cell Biol. 2004 Dec;24(24):10923-32
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory