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Gpat2 Gene Detail
Summary
  • Symbol
    Gpat2
  • Name
    glycerol-3-phosphate acyltransferase 2, mitochondrial
  • Synonyms
    A530057A03Rik, Gpat2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684962
    NCBI Gene: 215456
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:127425199-127436092 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 62.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684962
protein coding gene Chr2:127425154-127436093 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026459
protein coding gene Chr2:130718045-130728925 (+)
A/J MGP_AJ_G0026423
protein coding gene Chr2:125412416-125423296 (+)
AKR/J MGP_AKRJ_G0026398
protein coding gene Chr2:128994556-129005436 (+)
BALB/cJ MGP_BALBcJ_G0026435
protein coding gene Chr2:125680252-125691132 (+)
C3H/HeJ MGP_C3HHeJ_G0026178
protein coding gene Chr2:129509386-129520281 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026880
protein coding gene Chr2:134817232-134828125 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024257
protein coding gene Chr2:120255132-120265996 (+)
CAST/EiJ MGP_CASTEiJ_G0025639
protein coding gene Chr2:129715481-129726472 (+)
CBA/J MGP_CBAJ_G0026158
protein coding gene Chr2:139803406-139814301 (+)
DBA/2J MGP_DBA2J_G0026292
protein coding gene Chr2:124821726-124832621 (+)
FVB/NJ MGP_FVBNJ_G0026256
protein coding gene Chr2:123473444-123484324 (+)
LP/J MGP_LPJ_G0026397
protein coding gene Chr2:130945410-130956290 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026276
protein coding gene Chr2:143826319-143837199 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026935
protein coding gene Chr2:129019707-129030587 (+)
PWK/PhJ MGP_PWKPhJ_G0025375
protein coding gene Chr2:124369109-124380002 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025177
protein coding gene Chr2:128100500-128111418 (+)
WSB/EiJ MGP_WSBEiJ_G0025713
protein coding gene Chr2:129914059-129924952 (+)



Homology
more
  • Human Ortholog
    GPAT2, glycerol-3-phosphate acyltransferase 2, mitochondrial
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPAT2, glycerol-3-phosphate acyltransferase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT123
  • Links
    NCBI Gene ID: 150763
    neXtProt AC: NX_Q6NUI2
    UniProt: Q6NUI2

  • Chr Location
    2q11.2; chr2:96021946-96035974 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with decreased testis weight, impaired spermatogenesis, azoospermia, abnormal DNA methylation during gametogenesis, and increased male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046338 Ensembl Gene Model | MGI Sequence Detail 10894 C57BL/6J ±  kb
    transcript ENSMUST00000062211 Ensembl | MGI Sequence Detail 2628 Not Applicable  
    polypeptide ENSMUSP00000049619 Ensembl | MGI Sequence Detail 801 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008160 glycerol-3-phosphate acyltransferase 2, mitochondrial
    • EC
    • InterPro Domains
      IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
      IPR041728 GPAT/DHAPAT, acyltransferase domain
      IPR002123 Phospholipid/glycerol acyltransferase
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:277128 Shiromoto Y, et al., GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in micedagger. Biol Reprod. 2019 Jul 1;101(1):248-256

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory