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Tph2
Gene Detail
Symbol

Name
ID
Tph2
tryptophan hydroxylase 2
MGI:2651811
Feature Type
protein coding gene
Genetic Map
Chromosome 10
63.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:115078641-115185022 bp, - strand
From VEGA annotation of GRCm38

  106382 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27831  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine 3-monooxygenase
Gene Tree: Tph2

Human
homologs
Human Homolog TPH2, tryptophan hydroxylase 2
NCBI Gene ID 121278
neXtProt AC  NX_Q8IWU9
Human Synonyms  ADHD7, NTPH
Human Chr (Location)  12q21.1; chr12:71938846-72032441 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TPH2
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Spontaneous(2) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this locus result in abnormal serotonin levels in the brain. Whether an increase or decrease in serotonin levels is seen depends on the specific nucleotide substitution/point mutation.
 
Human Diseases Modeled Using Mouse Tph2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Tph2 interacts with 193 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process aromatic amino acid family metabolic process, metabolic process, ...
Component neuron projection
Function amino acid binding, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (147)    Tissues (133)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 142
RT-PCR 5
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020904 (Evidence)
Ensembl Gene ModelENSMUSG00000006764 (Evidence)
Entrez Gene216343 (Evidence)
UniGene31597
DFCITC1586425
DoTSDT.101351889
NIA Mouse Gene IndexU032232
EC1.14.16.4
Consensus CDS ProjectCCDS36061.1
International Mouse Knockout Project StatusTph2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020904 VEGA Gene Model | MGI Sequence Detail 106382 C57BL/6J ±  kb
transcript OTTMUST00000049410 VEGA | MGI Sequence Detail 2626 Not Applicable 
polypeptide OTTMUSP00000022885 VEGA | MGI Sequence Detail 488 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(1168 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002912 ACT domain
InterPro IPR001273 Aromatic amino acid hydroxylase
InterPro IPR019774 Aromatic amino acid hydroxylase, C-terminal
InterPro IPR018301 Aromatic amino acid hydroxylase, iron/copper binding site
InterPro IPR005963 Tryptophan 5-monooxygenase
InterPro IPR019773 Tyrosine 3-monooxygenase-like
Protein Ontology PR:000016576 tryptophan 5-hydroxylase 2
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:213172 Liu Z, et al., Dorsal raphe neurons signal reward through 5-HT and glutamate. Neuron. 2014 Mar 19;81(6):1360-74
All references(74)
Disease annotation references (1)
Other
accession IDs
MGI:2143765

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory