About   Help   FAQ
Tph2 Gene Detail
Summary
  • Symbol
    Tph2
  • Name
    tryptophan hydroxylase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2651811
    NCBI Gene: 216343
  • Gene Overview
    MyGene.info: TPH2
Location & Maps
more
  • Sequence Map
    Chr10:115078641-115185022 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106382 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 63.51 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TPH2, tryptophan hydroxylase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TPH2, tryptophan hydroxylase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADHD7, NTPH
  • Links
    NCBI Gene ID: 121278
    neXtProt AC: NX_Q8IWU9
    UniProt: Q8IWU9

  • Chr Location
    12q21.1; chr12:71938846-72032441 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tph2 mouse models; 2 with human TPH2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 12 alleles in 15 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this locus result in abnormal serotonin levels in the brain. Whether an increase or decrease in serotonin levels is seen depends on the specific nucleotide substitution/point mutation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020904 VEGA Gene Model | MGI Sequence Detail 106382 C57BL/6J ±  kb
transcript OTTMUST00000049410 VEGA | MGI Sequence Detail 2626 Not Applicable  
polypeptide OTTMUSP00000022885 VEGA | MGI Sequence Detail 488 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1161 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143765
References
more
  • Summaries
    All 97
    Developmental Gene Expression 24
    Diseases 1
    Gene Ontology 5
    Phenotypes 48
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:240101 Lv J, et al., 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017 Feb;214(2):529-545

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/19/2017
MGI 6.10
The Jackson Laboratory