Tph2
Gene Detail

Symbol Name ID

Tph2 tryptophan hydroxylase 2 MGI:2651811

Feature Type

protein coding gene

Genetic Map

Chromosome 10

63.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:115078641-115185022 bp, - strand From VEGA annotation of GRCm38   106382 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:27831  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine 3-monooxygenase
Gene Tree: Tph2

Human homologs

Human Homolog		TPH2, tryptophan hydroxylase 2
NCBI Gene ID		121278
neXtProt AC		NX_Q8IWU9
Human Synonyms		ADHD7, NTPH
Human Chr (Location)		12q21.1; chr12:72332626-72426221 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human TPH2

Alleles and phenotypes

All alleles(11) : Targeted(9) Spontaneous(2)
 

Mutations in this locus result in abnormal serotonin levels in the brain. Whether an increase or decrease in serotonin levels is seen depends on the specific nucleotide substitution/point mutation.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	aromatic amino acid family metabolic process, metabolic process, ...
Component	neuron projection
Function	amino acid binding, iron ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (147)    Tissues (133)    Images (19)
Theiler Stages: 2, 3, 4, 16, 17, 18, 19, 20, 22, 23, 28

Assay Type	Results
RNA in situ	142
RT-PCR	5

cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020904 (Evidence)
Ensembl Gene Model	ENSMUSG00000006764 (Evidence)
Entrez Gene	216343 (Evidence)
UniGene	31597
DFCI	TC1586425
DoTS	DT.101351889
NIA Mouse Gene Index	U032232
EC	1.14.16.4
Consensus CDS Project	CCDS36061.1
International Mouse Knockout Project Status	Tph2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020904	VEGA Gene Model | MGI Sequence Detail	106382	C57BL/6J
transcript	OTTMUST00000049410	VEGA | MGI Sequence Detail	2626	Not Applicable
polypeptide	OTTMUSP00000022885	VEGA | MGI Sequence Detail	488	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(355 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002912	ACT domain
InterPro	IPR001273	Aromatic amino acid hydroxylase
InterPro	IPR019774	Aromatic amino acid hydroxylase, C-terminal
InterPro	IPR018301	Aromatic amino acid hydroxylase, iron/copper binding site
InterPro	IPR005963	Tryptophan 5-monooxygenase
InterPro	IPR019773	Tyrosine 3-monooxygenase-like
Protein Ontology	PR:000016576	tryptophan 5-hydroxylase 2

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:191676 Manceau V, et al., The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS One. 2012;7(8):e43946
All references(65)

Other accession IDs

MGI:2143765