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Tph2 Gene Detail
Summary
  • Symbol
    Tph2
  • Name
    tryptophan hydroxylase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2651811
    NCBI Gene: 216343
Location & Maps
more
  • Sequence Map
    Chr10:115078641-115185022 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106382 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TPH2, tryptophan hydroxylase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TPH2, tryptophan hydroxylase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADHD7, NTPH
  • Links
    NCBI Gene ID: 121278
    neXtProt AC: NX_Q8IWU9

  • Chr Location
    12q21.1; chr12:71938846-72035297 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tph2 mouse models; 2 with human TPH2 associations

Human Disease Mouse Models
       Major Depressive Disorder; MDD   OMIM: 608516 View 1 model
       Attention Deficit-Hyperactivity Disorder, Susceptibility to, 7   OMIM: 613003
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 10 alleles in 14 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Spontaneous
    2
  • Targeted
    11
  • Genomic Mutations
    1 involving Tph2
  • Incidental Mutations
Mutations in this locus result in abnormal serotonin levels in the brain. Whether an increase or decrease in serotonin levels is seen depends on the specific nucleotide substitution/point mutation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020904 VEGA Gene Model | MGI Sequence Detail 106382 C57BL/6J ±  kb
transcript OTTMUST00000049410 VEGA | MGI Sequence Detail 2626 Not Applicable  
polypeptide OTTMUSP00000022885 VEGA | MGI Sequence Detail 488 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1168 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:2143765
References
more
  • Summaries
    All 78
    Developmental Gene Expression 20
    Diseases 1
    Gene Ontology 5
    Phenotypes 38
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:226300 Angoa-Perez M, et al., Brain serotonin signaling does not determine sexual preference in male mice. PLoS One. 2015;10(2):e0118603

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory