|
Symbol Name ID |
Tph2
tryptophan hydroxylase 2 MGI:2651811 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Lack of spontaneous play |
Impaired ability to form peer relationships |
Autism |
Inflexible adherence to routines |
Motor stereotypy |
Restrictive behavior |
| Disease(s) Associated with TPH2 | ||||||
| autistic disorder |
| Mouse Phenotypes | behavior/neurological phenotype |
decreased exploration in new environment |
abnormal emotion/affect behavior |
increased aggression |
increased aggression towards female mice |
increased aggression towards male mice |
decreased coping response |
increased anxiety-related response |
abnormal response to novel object |
decreased startle reflex |
weakness |
decreased locomotor activity |
induced hyperactivity |
no spontaneous movement |
abnormal sleep pattern |
abnormal maternal nurturing |
abnormal pup retrieval |
pup cannibalization |
abnormal mating preference |
|
| Availability | Mouse Genotype | |||||||||||||||||||
| Tph2em1(IMPC)Mbp/Tph2em1(IMPC)Mbp | ||||||||||||||||||||
| Tph2tm1.1Zfc/Tph2tm1.1Zfc | ||||||||||||||||||||
| Tph2tm1Bdr/Tph2tm1Bdr | ||||||||||||||||||||
| Tph2tm1Lex/Tph2tm1Lex | ||||||||||||||||||||
| Tph2tm1Mca/Tph2tm1Mca | ||||||||||||||||||||
| Tph2tm1Pasq/Tph2tm1Pasq | * | |||||||||||||||||||
| Tph2em1(IMPC)Mbp/Tph2+ | ||||||||||||||||||||
| Tph2tm1Mca/Tph2+ | ||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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