Sequence Detail

ID/Version

Q8CGV2 Q0VBT4 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2026-09-02

Sequence description from provider

RecName: Full=Tryptophan 5-hydroxylase 2; EC=1.14.16.4 {ECO:0000269|PubMed:12511643};AltName: Full=Neuronal tryptophan hydroxylase;AltName: Full=Tryptophan 5-monooxygenase 2;

Provider

SWISS-PROT

Sequence

Polypeptide 488 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tph2	tryptophan hydroxylase 2	20	124	3	30

Sequence references in MGI

J:81435 Walther DJ, et al., Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science. 2003 Jan 3;299(5603):76
J:150042 Alenina N, et al., Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10332-7
J:150637 Gutknecht L, et al., Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. J Neural Transm. 2008 Aug;115(8):1127-32
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:340399 Waider J, et al., Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice. Transl Psychiatry. 2017 Oct 3;7(10):e1246