65 phenotypes from 13 alleles in 16 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tph2Arg447/Tph2Arg447 BALB/cJ	abnormal serotonin level	J:94745
Tph2Arg447/Tph2Arg447 DBA/2J	abnormal serotonin level	J:94745
Tph2em1(IMPC)Mbp/Tph2+ C57BL/6N-Tph2em1(IMPC)Mbp/MbpMmucd	abnormal brain morphology	J:211773
	abnormal eye morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal placenta morphology	J:211773
	abnormal placenta vasculature	J:211773
	abnormal retina vasculature morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal testis morphology	J:211773
	decreased startle reflex	J:211773
	enlarged kidney	J:211773
	enlarged spleen	J:211773
	enlarged testis	J:211773
	increased brain size	J:211773
	increased prepulse inhibition	J:211773
	no spontaneous movement	J:211773
	persistence of hyaloid vascular system	J:211773
	small liver	J:211773
Tph2em1(IMPC)Mbp/Tph2em1(IMPC)Mbp C57BL/6N-Tph2em1(IMPC)Mbp/MbpMmucd	abnormal ovary morphology	J:211773
	abnormal placenta morphology	J:211773
	abnormal placenta vasculature	J:211773
	abnormal spleen morphology	J:211773
	decreased exploration in new environment	J:211773
	decreased locomotor activity	J:211773
	enlarged ovary	J:211773
	enlarged spleen	J:211773
	increased eosinophil cell number	J:211773
	no spontaneous movement	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Tph2Pro447/Tph2Pro447 129X1/SvJ	abnormal serotonin level	J:94745
Tph2Pro447/Tph2Pro447 C57BL/6J	abnormal serotonin level	J:94745
Tph2tm1.1Zfc/Tph2tm1.1Zfc involves: 129S7/SvEvBrd	abnormal mating preference	J:170988
	decreased serotonin level	J:170988
Tph2tm1.2Kpl/Tph2tm1.2Kpl involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal serotonergic neuron morphology	J:150637
	normal mortality/aging	J:150637
	normal nervous system phenotype	J:150637
Tph2tm1Bdr/Tph2tm1Bdr B6.129P2-Tph2tm1Bdr	abnormal skin condition	J:150042
	decreased body size	J:150042
	decreased circulating insulin-like growth factor I level	J:150042
	postnatal growth retardation	J:150042
	premature death	J:150042
	weakness	J:150042
Tph2tm1Bdr/Tph2tm1Bdr FVB.129P2-Tph2tm1Bdr	abnormal circadian regulation of heart rate	J:150042
	abnormal circadian regulation of systemic arterial blood pressure	J:150042
	abnormal skin condition	J:150042
	abnormal sleep pattern	J:150042
	decreased body size	J:150042
	decreased circulating insulin-like growth factor I level	J:150042
	decreased pulmonary respiratory rate	J:150042
	postnatal growth retardation	J:150042
	premature death	J:150042
	weakness	J:150042
Tph2tm1Bdr/Tph2tm1Bdr involves: 129P2/OlaHsd * FVB/N	abnormal autonomic nervous system physiology	J:150042
	abnormal circadian regulation of heart rate	J:150042
	abnormal circadian regulation of systemic arterial blood pressure	J:150042
	abnormal maternal nurturing	J:150042
	abnormal pup retrieval	J:150042
	abnormal skin condition	J:150042
	abnormal sleep pattern	J:150042
	decreased body size	J:150042
	decreased body weight	J:150042
	decreased circulating insulin-like growth factor I level	J:150042
	decreased pulmonary respiratory rate	J:150042
	decreased serotonin level	J:150042
	impaired adaptive thermogenesis	J:150042
	increased aggression	J:150042
	increased aggression towards female mice	J:150042
	induced hyperactivity	J:150042
	postnatal growth retardation	J:150042
	premature death	J:150042
	pup cannibalization	J:150042
	normal taste/olfaction phenotype	J:150042
Tph2tm1Dmkh/Tph2tm1Dmkh involves: C57BL/6	decreased serotonin level	J:196205
	increased core body temperature	J:196205
	normal nervous system phenotype	J:196205
Tph2tm1Lex/Tph2tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	abnormal emotion/affect behavior	J:144582
	abnormal response to novel object	J:144582
	decreased body length	J:144582
	decreased body weight	J:144582
	decreased serotonin level	J:144582
Tph2tm1Mca/Tph2+ involves: 129S6/SvEvTac * C57BL/6J	decreased coping response	J:131619
	decreased serotonin level	J:131619
	increased aggression towards male mice	J:131619
	increased anxiety-related response	J:131619
Tph2tm1Mca/Tph2tm1Mca involves: 129S6/SvEvTac * C57BL/6J	abnormal nervous system electrophysiology	J:196373
	decreased coping response	J:131619, J:196373
	decreased serotonin level	J:131619
	increased aggression towards male mice	J:131619
	increased anxiety-related response	J:131619
Tph2tm1Pasq/Tph2tm1.1Pasq involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal hippocampus morphology	J:188987
	abnormal paraventricular hypothalamic nucleus morphology	J:188987
	abnormal suprachiasmatic nucleus morphology	J:188987
	normal nervous system phenotype	J:188987
Tph2tm1Pasq/Tph2tm1Pasq either: (involves: 129P2/OlaHsd * C57BL/6) or B6.129P2-Tph2tm1Pasq	normal behavior/neurological phenotype	J:188987
	postnatal growth retardation	J:188987
	postnatal lethality, incomplete penetrance	J:188987
Tph2tm2.1Pasq/Tph2tm2.1Pasq B6.129P2(SJL)-Tph2tm2.1Pasq	no abnormal phenotype detected	J:238619
Tph2tm2.1Pasq/Tph2tm2.2Pasq Tg(CMV-cre/ERT)1Ipc/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	decreased serotonin level	J:238619
Tph2tm2.2Pasq/Tph2tm2.2Pasq involves: 129P2/OlaHsd * C57BL/6 * SJL	decreased body weight	J:238619
	decreased serotonin level	J:238619
	postnatal lethality, incomplete penetrance	J:238619