Tph2^tm1Bdr
Targeted Allele Detail

Summary

• Symbol: Tph2^tm1Bdr
• Name: tryptophan hydroxylase 2; targeted mutation 1, Michael Bader
• MGI ID: MGI:3849838
• Gene: Tph2 Location: Chr10:114914546-115020927 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Tph2^tm1Bdr page

Growth retardation and postnatal lethality in Tph2^tm1Bdr/Tph2^tm1Bdr mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150042
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 1 and exon 2 were replaced with a neo cassette. The absence of transcripts coding for exons 1 through 6 was confirmed by western blot analysis on brain extracts. (J:150042)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph2 Mutation: 41 strains or lines available

References

• Original: J:150042 Alenina N, et al., Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10332-7
• All: 9 reference(s)